Name: NA Selank Amidate
Brand: MOL Changes
SKU: 198884

NA Selank Amidate na-egosipụta nkwụsi ike molekụla emelitere yana na vivo pharmacokinetic profaịlụ site na atụmatụ mgbanwe okpukpu abụọ nke N-terminal acetylation na C-terminal amidation dabeere na mbụ Ọdịdị nke Selank.

Nke a na-ebute mmụba ọkara ndụ, emelitere mgbochi ụbụrụ ọbara ntinye arụmọrụ, na bioactivity ogologo oge n'ụdị molekụla na ụdị anụmanụ.

Ọzọkwa, NA Selank Amidate gosipụtara ike immunomodulation na mgbochi nchekasị ọrụ.

Usoro

ac-thr-lys-pro-arg-pro-gly-pro-nh2

Nọmba CAS

Usoro ihe omimi

C35H60N12O9

Ibu molekụla

792.94

Nnyocha nke NA Selank Amidate

1.Ejigidere yana arụkwa ọrụ arụmọrụ

Ịrụ ọrụ-maara ihe,NA Selank Amidate na-ejigide njirimara Selank niile, na-achịkwa gamma-aminobutyric acid (GABA) neurotransmission na ụbụrụ mgbe na-modulating na dopaminergic na serotonergic sistemu eji eme ihe dị mkpa anxiolytic na antidepressant mmetụta.

Ọ na-egosipụtakwa arụmọrụ ka mma karịa Selank n'ịkwalite ọrụ ọgụgụ isi na neuroprotective, na-emepụta mmetụta dị mma akpọpụtara na mmụta, ebe nchekwa, na nlebara anya.

2.Mmetụta anxiolytic na mmetụta na-eme ka ọ kwụsie ike

N'ụzọ dabere na ntinye uche na subtype-ahọpụtara, NA Selank Amidate allosterically modulates nke GABA-A nnabata site n'ịkwalite ịdị irè nke GABA na onye nata ya ma ọ bụ ịkwalite ya ion ọwa chloride mmeghe arụmọrụ.

Nke a na-abawanye nke ukwuu ụda mgbochi na sekit ụbụrụ isi, na-emepụta mmetụta anxiolytic akara.

Ọzọkwa, Mmetụta nke mmetụta anxiolytic a dị ntakịrị karịa nke ọgwụ anxiolytic nke a na-emekarị, na-eme NA Selank Amidate ka ọ bụrụ ogige na-eme ka ọnọdụ obi dịkwuo mma.

3.Nkwalite ọgụgụ isi na nchedo Neuro

NA Selank Amidate na-arụ ọrụ ozugbo BDNF transcript nke mkpụrụ ndụ ihe nketa site na inducing phosphorylation nke onye nkwalite-dị CREB ihe odide ederede na acetylation nke histone H3, na-abawanye BDNF mRNA ọkwa 3.2-fold na hippocampal dentate gyrus granule cell na prefrontal cortical pyramidal neurons na protein secretion 2.8-fold n'ime. 24 awa.

Nke a na-arụ ọrụ TrkB ụzọ mgbama nnata mgbada, na-ebute Ras-MAPK na PI3K-Iwu cascade na-abawanye spine dendritic njupụta site 39%, kwalite okwu synaptophysin site na 45%, ma weghachite njupụta LTP na ntọala.

Nke a nke ọma na-egbochi mmerụ ahụ neuronal hippocampal na-akpata nchekasị na mbelata ọgụgụ isi, na-egosipụta ihe dị iche iche neuroprotective.

4.Mmetụta Immunomodulatory na Mgbochi Nchegbu

NA Selank Amidate bụ ihe mgbochi nke enkephalin na-emebi emebi, na-echebe endogenous opioid peptides si hydrolysis ma si otú a na-ebuli ọkwa ha elu, mgbe ọ na-egbochi LPS (lipopolysaccharide)-kpalitere okwu pro-inflammatory cytokines gụnyere IL-6 na TNF-a site na 40-60% astrocytes.

NA Selank Amidate na-egbochikwa ntụgharị NF-κB nuklia site na itinye aka na ntinye nke protein nkwụnye MyD88., inye iwu nchebe na microenvironment neuroinflammatory.

COA

HPLC

MS

(1) Anyị chọrọ, C. R.; Ọcha, C. M. Ndị na-ahụ maka Sedative-Hypnotic na-emetụta Gamma-Aminobutyric Acid Nnabata.: Gbado anya na Flunitrazepam, Gamma-hydroxybutyric acid, Phenibut, na Selank. J Clin Pharmacol 2021, 61 Nkwado 2, S114-S128. DOI: 10.1002/jcph.1922 Site na NLM M

(2) Ihe dara ogbenye, A.; Kolomin, T.; Andreeva, L.; Bondarenko, E.; Myasoedov, N.; Slominsky, P.; Shadrina, M. Peptide Selank na-akwalite mmetụta nke Diazepam na ibelata nchekasị na ọnọdụ nrụgide dị nro na-adịghị ala ala na oke oke.. Ọrịa Neurol 2017, 2017, 50910

(3) Ntụtụ, L. G.; Nadorova, A. V.; Antipova, T. A.; Kruglov, S. V.; Kudrin, V. S.; Durnev, A. D. Selank, Peptide Analogue nke Tuftsin, Na-echebe megide mmerụ ahụ ebe nchekwa ethanol kpatara site na ịhazi ọdịnaya BDNF na Hippocampus na Prefrontal Cortex.

(4) Ntụtụ, L. G.; Nadorova, A. V.; Seredenin, S. B. Selank na-egbochi Hyperlocomotion nke Ethanol kpatara na ngosipụta nke mmetụta omume na ụmụ oke DBA/2. Bull Exp Biol Med 2016, 162 (1), 56-59. DOI: 10.1007/s10517-016-3544-6 Site na NLM Medline.

(5) Ọnụ, N. V.; Sokolov, O.; Gabaeva, M. V.; Grivennikov, I. A.; Andreeva, L. A.; Miasoedov, N. F.; Zozulia, A. A. [Semax na selank na-egbochi enzymes na-emebi emebi nke enkephalin sitere na serum mmadụ]]. Bioorg Khim 2001, 27 (3), 180-183. DOI: 10.1023/a:10113730028

(6) Amaghị m, G. G.; Teleshova, E. S.; Bochkarev, V. K.; Koschelev, V. V.; Syunyakov, T. S. P.3.036 Akwụkwọ akụkọ anxiolytic Selank: Nsonaazụ nke nnwale ụlọọgwụ nke Phase II. European Neuropsychopharmacology 2005, 15, S159-S160. DOI: 10.1016/s0924-977x(05)80332-3.

(7) Slominsky, P. A.; Shadrina, M. I.; Kolomin, T. A.; Stavrovskaya, A. V.; Filatova, E. V.; Andreeva, L. A.; Illarioshkin, S. N.; Myasoedov, N. F. Peptides semax na selank na-emetụta omume nke oke na 6-OHDA kpalitere PD dị ka parkinsonism.. Ruo mgbe Biol Sc

(8) Sollertinskaja, T. N.; Shorokhov, M. V.; Myasoedov, N. F. Mmetụta cerebrotective nke Semax na Selank na primates na ụdị neurosis dị iche iche. Akwụkwọ akụkọ International nke Psychophysiology 2008, 69 (3). DOI: 10.1016/j.ijpsycho.2008.05.356.

Usoro:	ac-thr-lys-pro-arg-pro-gly-pro-nh2
CAS:	/
M.W:	792.94 g/mol