Oxytocin

Nnyocha metụtara nke Oxytocin

1.Na-akpali akpali Mgbagwoju anya nke akpanwa

Ebe ọ bụ na nchoputa ya, A na-eji oxytocin eme ihe n'ụzọ bụ isi maka ebumnuche a – na-akpali akpali nke akpanwa contractions, na-eke ọnọdụ dị mma maka parturition. Ọ na-ejikọta na ndị na-anabata oxytocin (ụdị nke G na-anabata protein jikọtara ọnụ) dị na Eriri akpa nwa na-eji ire ụtọ mkpụrụ ndụ. Ntinye nke kpọmkwem ọwa calcium n'ime akpụkpọ ahụ cell na-eduga na mmụba dị ịrịba ama na calcium intracellular itinye uche.

Myosin ọkụ-chain kinase na-arụ ọrụ, na-ebute mkpụkọ rhythmic ahụ e kwuru n'elu nke ma ọ dịkarịa ala akwara dị nro nke endometrial. Ndị a 'top-down’ nkwekọrịta yiri nke ọma iji aka na-ebugharị nwa ebu n'afọ n'èzí.

Nnwale ụlọọgwụ egosila nchịkwa intravenous iji belata oge nkwekọrịta n'etiti 2-3 nkeji; ịgbatị ogologo oge bụkwa mmetụta edepụtara nke ọma, A na-esi otú a na-emepụta nkwekọrịta ọrụ dị irè. Nnyocha ndị ọzọ na-egosi na nkwekọrịta nke oxytocin na-ebute abụghị nanị ihe na-eme ka ọ dị mfe na nnyefe, mgbe amuchara nwa ngwa ngwa mmechi vaskụla na saịtị nkewa (igbochi ọbara ọgbụgba bụ otu n'ime nsonaazụ kacha mkpa) na-ekere òkè dị mkpa nso.

2.Na-akwalite mwepụ mmiri ara ehi

Mwepu mmiri ara ehi na-adabere na sistemụ reflex neuroendocrine, The le-down reflex. Nwa ọhụrụ na-aṅụ ara nne na-enye mkpali mbụ, njedebe akwara na-ebunye akara ngosi na hypothalamus. A na-emepụta Oxytocin ma hapụ ya ebe ahụ, traveling through the bloodstream to act on myoepithelial cells (surrounding mammary alveoli and smaller ducts), their contraction being the end result of milk ejection.

One study found maternal behavior in female mice was suppressed after 3 hours of fasting, active milk secretion being one of the suppressed behaviors. Exogenous oxytocin restored this behavior completely – direct proof of its efficacy in promoting milk ejection.

3.Promoting Prosocial Behavior

Social interactions are to some degree hardwired into the human brain. Selfish individuals use primarily the orbitofrontal cortex (OFC) to process all forms of ‘social value’, prosocial individuals more so the amygdala. Equitable distribution is a naturally occurring prosocial outcome.

E gosiputara nchịkwa Oxytocin ka ọ na-akwali ndị na-achọ ọdịmma onwe ha naanị n'omume dabere na mmekọrịta mmadụ na ibe ya.

4.Usoro nhazi nke obi na mmezi anụ ahụ

Ọrịa obi bụ ihe kacha akpata ọnwụ n'ụwa niile. Myocardial infarction na-ebute oke ọnwụ cardiomyocyte; enweghị ikike nrụzi onwe onye dị nso n'ime cardiomyocytes okenye na-anọchite anya ihe mgbochi bụ isi maka ụdị mgbake obi ọ bụla..

Na-esochi mmerụ ahụ cryogenic na obi zebrafish, Ndị nchọpụta chọpụtara mmụba nke oxytocin mRNA n'ụbụrụ, N'ihi ya, oxytocin na-adịgide adịgide kpọmkwem n'ime obi n'onwe ya. Mgbochi kemịkalụ nke okwu oxytocin a na-egbochiri usoro nrụzi obi niile enwere ike tụọ. – ịgbalite mkpụrụ ndụ epicardial ọhụrụ bụ otu n'ime ihe atụ pụtara ìhè.

Ọmụmụ ihe a bụ nke mbụ gosipụtara n'ụzọ doro anya mkpa oxytocin, ọrụ na-akwalite ma ọ dịkarịa ala akụkụ ụfọdụ nke mmezi cell obi.

5.mgbochi mkpali

N'ụdị dị iche iche nke ọrịa obi, Mfụfụ na-adị ala mgbe niile na nrụgide oxidative jikọtara ya bụ ihe ọzọ na-egbochi ihe mgbochi zuru ụwa ọnụ maka nrụzi cell kwesịrị ekwesị. Oxytocin na-ebelata ntọhapụ na nkwupụta nke ọtụtụ ihe na-akpata mkpali, na-ebelata ọgbọ nke ezi mkpụrụ ndụ mkpali, na site emelitere (endogenous) antioxidants dị ka glutathione peroxidase, na-ebelata akụkụ niile nke mmebi oxidative ahụ.

6.Na-achịkwa agụụ na Metabolism

Oxytocin na-arụ ọrụ dị mkpa edekọ nke ọma na ma agụụ na metabolism n'ozuzu ya. Ejikọtara ya na neurons hypothalamic nke na-arụ ọrụ na nso mpaghara ụbụrụ niile, ọ na-amụba akara satiety (ụbụrụ ụbụrụ dabeere) – a nso ozugbo siri ike ‘uju’ ịbụ ọgwụgwụ nke nri.

Usoro sistemu ụjọ nke etiti kpọmkwem na dopamine na-achọ ụzọ na-ebelata mkpali ịchọ nri nri dị elu (abụba/sugar bụ ezigbo atụ). Nnyocha egosiwokwa oxytocin na-abawanye insulin site na pancreatic β-mkpụrụ ndụ, na welie glucose homeostasis.