Thymogen bụ anụ ahụ immunomodulatory peptide sitere na gland thymus. Nke mbụ dịpụrụ adịpụ ma dị ọcha site na anụ anụ thymus wepụ na mmalite 1970s, aha ya bụ 'Thymogen’ na-egosipụta isi ọrụ ya – na-akpali akpali iche nke mkpụrụ ndụ tupu T n'ime ụdị ọrụ dị iche iche sel T.
Mgbakwunye ọgwụgwọ immunological Ya mere, a na-eji peptide a eme ihe nke ọma.
Usoro
Glu-Trp
Nọmba CAS
/
Usoro ihe omimi
C16H19N3O5
Ibu molekụla
333.344
Nnyocha nke Thymogen Peptide
1.Usoro nke Omume
Ntinye aka nke ọma na nke ziri ezi n'ime mmụba na ntozu oke ọrụ nke ndị a lymphocytes bụ otu n'ime isi njirimara ya. Endogenous homonụ nke thymic’ Thymogen na-akwalite ọrụ ndu; na-emekọrịta ihe na ụzọ mgbama mgbada ala, peptide na-akwalite njikọ na ma ọ dịkarịa ala nzuzo nzuzo dị mkpa cytokines (IL-2 ịbụ ezigbo ihe atụ), na nkwalite nke ndị na-anabata IL-2 dị elu.
2.Ngwa ụlọ ọgwụ
Ọgwụgwọ ụlọ ọgwụ nke Thymogen na-ekwu kpọmkwem ihe mgbochi nje na mgbochi intracellular nke ahụ.; nleba anya nke mgbochi ọrịa na mkpochapụ nke ụfọdụ mkpụrụ ndụ etuto bụ nsonaazụ abụọ a na-achọsi ike.
Mbelata na nọmba cell T kpọmkwem ma ọ bụ mmebi arụ ọrụ dị iche iche immunodeficiency enwere ike idozi steeti. Na-eweghachi ahụ Th1/th2 itule bụkwa akụkụ nke ike ụlọ ọgwụ ya.
3.T Lymphocyte Development
Na-akwalite (na ịnọgide na-enwe) T lymphocyte mmepe, ọdịiche na akụkụ niile metụtara maturation: Na-eṅomi microenvironment nke thymic, Thymogen na-arụ ọrụ ozugbo na 'isi’ nke usoro ahụ ji alụso ọrịa ọgụ.
Ihe jikọrọ ọnụ na sel lekwasịrị anya na akara intracellular na-esote bụ ihe na-akpali usoro a.
Mkpụrụ ndụ cell T tozuru oke bụ ngwaahịa ikpeazụ, nkịtị ọdọ mmiri size na ọrụ ịbụ ezigbo njedebe ọnọdụ nke iwu ahụ na-achọ.
Mbelata nke mgbochi ọrịa ịka nká bụ otu n'ime ihe ịma aka ụlọ ọgwụ kacha mkpa nke Thymogen na-enye ezigbo enyemaka na-enweghị atụ..
4.Mgbochi na-efe efe
Na-akwalite nzaghachi mgbochi cellular na ikike mgbochi ọrịa: Thymogen na-eme ka arụmọrụ nke nzaghachi mgbochi sel nke anụ ahụ dịkwuo mma.
Site na mbuso agha pathogen, Thymogen na-akwalite sel T nke ọma iji zoo cytokines isi dị iche iche; kpọmkwem phagocytosis na igbu egbu nje na-esote na-enyere aka nke ukwuu site na ihe ndị a.
Ngwa ụlọ ọgwụ nke Thymogen na-egosi ọganihu dị mma na nchekwa nke anụ ahụ megide ma ọrịa na-adịghị ala ala ma na-emekarị, na-ebelata usoro nke ọrịa ndị dị otú ahụ, ibelata ugboro ugboro nke nlọghachi; Ndị ọrịa adịghị arụ ọrụ nke ọma na-erite uru nke ukwuu n'akụkụ omume ya.
5.Mmetụta mgbochi tumor na-agbakwunye
Thymogen nwere ike ịbawanye nke ọma Cytotoxic T cell / CTL ọrụ na mmụba, niile metụtara kpọmkwem mmepụta cytokine (IFN-γ ịbụ ezigbo ihe atụ).
Ịghọta na ikpochapụ mkpụrụ ndụ tumo bụ akụkụ nke ọrụ mbụ nke usoro ahụ ji alụso ọrịa ọgụ., mgbochi ọrịa onyunyo ịbụ okwu kacha nke ejiri.
Usoro ọgwụgwọ redio na chemotherapy na-emebi usoro hematopoietic na nke na-alụso ọrịa ọgụ ruo n'ókè ụfọdụ; Mgbe ọgwụgwọ gasịrị, mmebi ahụ ji alụso ọrịa ọgụ bụ mmetụta dị n'akwụkwọ nke ọma.
Iji thymogen mee ihe n'ọnọdụ a na-enyere ahụ onye ọrịa aka ịgbake ọrụ mgbochi site na mmebi kwuru, a na-ebelata ọrịa na-efe efe n'otu oge, mma ndụ mma.
COA
HPLC
MS
