E pei o se analog fausaga o α-MSH (melanocyte-stimulating hormone), Melanotan-II (MT-II) fa'aalia meatotino e tutusa ma le α-MSH. E galue o se mea e le filifilia melanocortin receptor agonist, faʻaalia le gaioiga i le melanocortin receptors MC1R, MC3R, MC4R ma MC5R.
Fa'atulagaina, Melanotan-II o se taamilosaga heptapeptide (Ac-Nle-cyclo[Asp-Lana-DPhe-Arg-Trp-Lys]-NH₂). O lenei fausaga fa'ata'amilosaga e maua ai se filifili peptide pu'upu'u nai lo le laina MT-I.
E ui o suʻesuʻega in vitro o loʻo faʻaalia ai le Melanotan-II o loʻo faʻaalia le sili atu le malosi nai lo Melanotan-I i le faʻagaoioia. melanocyte MC1R e fa'aoso ai le fa'apogai, Melanotan-II ua maua o loʻo iai ni faʻamanuiaga i isi itu, aemaise i le fa'atonutonuina o le tino.
Fa'asologa
faia-{E mafai}-Asp-Lana-{d-Fe}-Arg-Trp-Lys-NH2, (2→7)-lactam
Numera CAS
121062-08-6
Fuafua mole
C50H69N15O9
Molecular Weight
1024.18
Suesuega O Melanotan-II
1.o le a le melanotan-II
1)Su'esu'ega ma Atina'e
O le Melanotan-II o se vailaʻau faʻamaʻi faʻamaʻi melanocortin na faʻavaeina muamua mo le puipuia o le kanesa o le paʻu. Peitai, o lona mauaina fa'afuase'i o le fatugalemu o le tino ma fa'afeusuaiga fa'atonutonu a'afiaga ua fa'alauteleina ai ana fa'aoga talafeagai i le tele o matā'upu..
2) Aafiaga Pigmentation Pa'u
E pei o se analog o le α-MSH, Melanotan-II e mafai ona faʻagaoioia melanocytes ma faʻaosofia le paʻu o le paʻu. I se suʻesuʻega e tasi-tauaso, e toʻatolu tagata auai na mauaina le saline poʻo le Melanotan-II e ala i le tuiina o le subcutaneous faʻatasi i aso taʻitasi i aso o le vaiaso mo le lua vaiaso.
Sa toe faia fua i le nofoaga lava e tasi i le aso 21. O su'esu'ega va'aia na fa'aalia ai le mata'utia o foliga i tagata auai pe a mae'a le fa'atonuga. O faʻamaoniga e faʻaalia ai o Melanotan-II e faʻamalosia le tanning e ala i lana gaioiga o se agonist i le MC1R i melanocytes¹.
3)Togafitiga Fa'aletonu o le Erectile
Melanotan-II e mafai ona togafitia male fa'aletonu erectile (ED). I se vaega itiiti o 10 tagata gasegase e maua i le psychogenic ED, tui lalo o le peptide (0.025 mg/kg mamafa o le tino) sa iloiloina e ala i le mata'ituina taimi moni i totonu 6 itula: 8 na ausia e tamaloloa ni fa'atonuga aoga².
O nei su'esu'ega na mulimuli ane fa'amaonia i se su'esu'ega fa'alua tauaso³.
4)Aafiaga Metabolic
O suʻesuʻega a manu ua faʻaalia ai o Melanotan-II e taofiofia le manaʻo ma faʻateleina le gaʻo. Na tu'itu'i fa'apitoa e tagata su'esu'e le PTP1B(Polotini Tyrosine Phosphatase 1B) gene (ose fa'atonuga leaga ole fa'ailoga leptin) i totonu POMC(Proopiomelanocortin) neu o isumu.
O nei isumu mutant na fa'aalia le malosi o tali i tui intracerebroventricular o leptin ma Melanotan-II (o se agonist talitali melanocortin), o lo'o fa'aalia e pei o le fa'atupuina o le tu'ina o le mana'o, pa'u mamafa, ma thermogenic tali.
E lē gata i lea, o lenei tapeina faʻavae na mafua ai le faʻateleina o faʻamatalaga o le MC4R receptor i isumu⁴.
2.Fa'ai'uga
Melanotan-II, e pei o se mea e le filifilia le melanocortin receptor agonist, not only shows promise for inducing skin pigmentation but has also garnered significant scientific interest for its potent centrally mediated effects on sexual function regulation, particularly in improving ED.
Its preliminary clinical results in ED treatment are encouraging, ma lona pleiotropic mechanism of action establishes a promising foundation for the development of novel ED therapeutics.
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