Cagrilintide ndeyekureba ichiita amylin analog. Amylin ihomoni yepeptide yakabatanidzwa ne pancreatic β-masero pamwe ne insulin; kudzora kuenzana kwesimba kuburikidza nekuguta, kunonoka kubuda mudumbu, uye glucagon inhibition.
Zvinowanzoitika amylin zvakadaro, anounganidza zviri nyore uye ane hutsika husina kunaka, kuderedza kushandiswa kwavo kwekliniki. Ekutanga amylin-yakatorwa analogs senge pramlintide inodiwa kakawanda majekiseni nekuda kwe suboptimal pharmacokinetics yekurapa maitiro mumhando 2 chirwere cheshuga.
Cagrilintide inowana ichi chiitiko chakareba kuburikidza neyakasiyana mafuta acid cheni shanduko – kamwe pavhiki dosing ndiyo yekupedzisira inotsvakwa. Miedzo yemakiriniki yakaratidza kuda kudya kunodzvinyirira mhedzisiro, imwe nzira yekuwedzera yekuita iri kuratidzwa kana ichienzaniswa nesemaglutide.
A fixed ratio musanganiswa (CagriSema) yakagadzirwa. Yekuedza-kurasikirwa kwedata inoratidza musanganiswa unodarika chero mumiririri wega mukubudirira.
Kuenderera mberi kwekufambira mberi kwecagrilintide kunowedzera iyo yakambotsanangurwa kurapa kugona kweamylin mimetics.; multi-target synergistic kurapwa kwe metabolic kusagadzikana ndiyo yakajeka ramangwana gwara.
Kutevedzana
{Eicsanedioic acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Thr-Val-Asn-Val- (Disulfide zambuko:Cys3-Cys8)
Nhamba yeCAS
1415456-99-3
Molecular Formula
C194H312N54O59S2
Molecular Weight
4409.01 g/mol
Cagrilintide Related Research
1.Kudzvinyirirwa Kwekudya uye Kuwedzera Kuguta
Seye amylin analog, kukurumidza kuyambuka kweropa rehuropi chipingamupinyi ndicho chinhu chakakosha pakuita kweCagrilintide.
Kunanga kwakananga kweakananga matunhu ehuropi anodzora yakachena 'nzara’ ndizvo zvinozvitsaura – activation ye calcitonin receptor (simba rinokwana chiratidzo) zvinoderedza, kana zvisina kubvisa, chikafu chishuwo nechepakati.
Willpower based dieting haigone kudzokorora shanduko iyi yepanyama kune yakatarwa yemunhu.
2.Kunonoka kubuda mugastric uye zvese zvinotevera kugaya
Kudzivirirwa kwegastric smooth muscle contractions uye kuzorora zvishoma kwepylorus kunopa imwe chimiro chemuviri chekuzara kwakasimba..
Kunwa kwechikafu kunoderedzwa, postprandial ropa glucose (uye pamwero mukuru ese metabolic parameters) dzinochengetwa dzakatsiga sezvinobvira.
3.Inhibits postprandial glucagon secretion
Glucagon ihomoni inokurudzira hepatic glycogenolysis uye gluconeogenesis; zvinobudirira kushanda se hyperglycemic agent.
Cagrilintide inoteedzera iyo chaiyo postprandial secretion iyo alpha masero make, kuratidza kuburikidza nehurongwa hwehuropi hwetsinga kuti kusunungurwa uku kwakaitika.
Kudzikisira kwakakosha mune yakataurwa secretion ndiyo mhedzisiro – kudzikisa postprandial glucose yeropa kuve imwe yemabhenefiti ekutanga.
Kuvandudza maitiro ezvokudya zvemhando 2 varwere vane chirwere cheshuga vanonyatsobatanidzwa kune iyi nzira; kushandisa marudzi akasiyana-siyana e‘simba’ inogona kusvikirwa nepedyo-yakazara chivimbo pasina kugara uchitarisa glucose.
4.Synergistic Chiito ne GLP-1 Receptor agonists
Nzira dzinopindirana dzakakwirira dzinoratidzwa pakati pecagrilintide neava agonist.
GLP-1 pachayo inotarisa zvakanyanya pane satiety, nepo amylin analogues (kusvika pamwero wakakwana) kudzvinyirira marudzi ose enzara.
A dual mechanism, multi-targeted pathophysiology yakavakirwa nzira yekufutisa uye chirwere cheshuga ndiyo iyo musanganiswa unopa.
Zvidzidzo (CagriSema ndiyo yazvino) vakaratidza kurasikirwa kwehuremu hwepamusoro uye yakagadziridzwa glycemic control kana ese ari maviri akashandiswa pamwechete.
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