Glycinamide hydrochloride

I. Peptides le Patlisiso ea Biology ea Lik'hemik'hale

1. Mehaho ea C-terminal Amidation bakeng sa Peptides
Solid-phase/Mokelikeli-phase peptide synthesis, ho kenyelletsa C-terminal glycine amide (–Gly–NH₂). Li-peptide tse ngata tsa bioactive li hloka phetoho ea C-terminal amide ho matlafatsa khanyetso ho proteolysis le ho ntlafatsa biostability.; glycine amide ea mahala e na le tšekamelo ea ho senyeha haholo, athe letsoai la eona la hydrochloride ke setala, lisebelisoa tse tala tse sebelisoang ho kopanya peptide le kaho ea laeborari ea peptide.
2. Bioconjugation le Patlisiso ea Phetoho ea Liprotheine
E na le sehlopha sa mahala sa amine se khonang ho kopana le lihlopha tse kenyang tšebetsong tse kang li-ester tsa NHS, e sebetsa e le li-substrates tsa mohlala bakeng sa ho ngola lihlopha tsa protheine le fluorescent.
3. Li-precursors tsa Heterocyclic le Metal Complex Synthesis

– Synthesis ea imidazolidine-4-one le diazaspiro metsoako;
– Tokisetso ea Ir le Rh organometallic luminescent complexes bakeng sa tšebeliso ea photochemistry le lipatlisiso tsa photocatalysis..

II. Liteko tsa Biochemical: Physiological pH Buffer Reagents

pKa ≈ 8.20, sebaka se sebetsang sa buffer 7.2–9.2; e khetholloa e le sistimi e "ntle" ea buffer:

– Litlhahlobo tsa ts'ebetso ea enzyme: E loketse liteko tsa enzyme kinetics tlas'a maemo a alkaline hanyane;
– Buffer bakeng sa in vitro cell culture; lokisa setoko tharollo ka sterilizing ka 0.22 μm tlhoekiso;
– Sistimi ea tharollo ea protheine: Metsi a qhibilihang haholo, e tsamaellanang le liprotheine tse ngata, 'me e hanana le pula ea protheine.

III. Lesapo la Lesapo / Biology ea Stem Cell (Lihlooho Tse Chesang Haufinyane)

1. Ho thehoa ha Protein-Glycinamide Nanocomposites
Li-nanocomposites tsena tse qosoang hantle li bokana ho li-submicron nanoparticles ka ho sebelisana ha electrostatic le liprotheine tse qosoang hampe. (BSA, BMP-2), ho matlafatsa ts'ebetso ea ts'ebeliso ea liprotheine ka lisele le ho ntlafatsa phano ea liprotheine tse kopaneng.
2. Kholiso ea Synergistic ea Phapang ea Osteogenic le BMP-2
E phahamisa liphatsa tsa lefutso tsa osteogenic joalo ka Runx2, ALP, le Col1a1; e ntlafatsa ts'ebetso ea alkaline phosphatase le synthesis ea collagen; a mouse cranial defect model e tiisa hore synergistic promotion of in vivo bone bone regeneration, e sebetsang ho lisebelisoa tsa ho lokisa masapo le lipatlisiso tsa mekhoa ea ho tsosolosa masapo (PMC).

IV. Letlalo la Pigmentation le Melanocyte Research Model System (PMC)

Litsela tsa lipontšo mefuteng ea lipatlisiso:
E thibela pontšo e hlahisoang ke α-MSH, e theola MITF le tyrosinase (TYR) poleloana, le ho fokotsa tlhahiso ea melanin;
E sebelisetsoa ho etsa lipatlisiso ka mekhoa ea ho soeufala ha letlalo le mekhoa ea mebala; ho na le palo e lekanyelitsoeng ea lithuto tsa in vitro le tsa pele tsa batho, empa e ntse e le hole le ho ba sehlahisoa sa meriana kapa setlolo se felileng 'me se lekanyelitsoe litekong tsa lipatlisiso..

V. Li-Enzyme le Metabolic Pathway Tool Substrates / Analogues

1. Li-analogue tsa sebopeho sa Glycine, e sebelisetsoang ho ithuta lipalangoang tsa amino acid le litsamaiso tsa ho nkela amino acid;
2. Lipatlisiso tsa sebopeho sa analoge bakeng sa tsela ea purine synthesis (ho khetholla GAR [glycinyl-adenosyl-ribonucleotide]), e thusa ho hlakisa tlhokomelo ea substrate le libaka tse sebetsang tsa li-enzyme tsa purine biosynthetic..

VI. Lipatlisiso tsa Motheo ho Chemistry ea Meriana

Joalo ka litene tsa ho aha tsa maiketsetso:

– Li-precursors tsa bohlokoa tsa laboratori bakeng sa lithethefatsi tsa neuroprotective joalo ka oracitane;
– Ho hahoa ha lilaebrari tsa limolek'hule tsa heterocyclic tsa pyrazine le imidazoles bakeng sa ho hlahloba metsoako e nyenyane ea molek'hule..

Lintlha Tse ka Sehloohong Tsa Tšebeliso ea Lipatlisiso

1. Haholo-holo hygroscopic; lekanya le ho lokisa tharollo kapele; lokisa litharollo tse nang le metsi a macha ha ho khoneha;
2. Li-buffer li hloka phetoho e nepahetseng ea pH ka NaOH/HCl, e lateloe ke ho tlhotla le ho nyopisa;
3. Bakeng sa liteko tsa baeloji, kenyeletsa sehlopha sa taolo ea glycine ho khetholla liphello tse itseng tse bakoang ke sehlopha sa amide.