Peptide ea FRET ke eng?

Li-nanosensors tse kenang ka har'a hlahala tsa Ultrasensitive tsa tšebetso ea protease

Bokhoni ba ho tseba maqeba a mofets'e ka li-biomarker tsa endo native hajoale bo lekanyelitsoe ho lihlahala ~ 1 cm ka bophara. Haufinyane tjena re tlalehile nanosensor e kenang ka mokhoa o sa tloaelehang e kenang ka har'a hlahala e tsoang, karabelo ho li-protease tse ikhethileng ka hlahala, likhechana tsa peptide tse ka bonoang ka har'a moroto. Mona, re tlaleha optimization, e itšetlehile ka mohlala oa lipalo oa pharmacokinetic, Ponahalo ea bokaholimo ba likarolo tsa peptide ho ntlafatsa ho qhekella ha protease le ho fokotsa ho qhekella ha sepheo., le ea ts'ebetso ea li-nanosensors tse nang le li-ligands tse kenang ka har'a hlaha tse kenyang litsela tse sebetsang tsa ho rekisa ho eketsa ts'ebetso ea tumor microenvironment.. Sephetho sa nanosensor se ile sa khetholla maqeba a ka tlase ho limilimithara tse 5 ka har'a lihlahala tsa epithelial ea motho mme a bona maqhutsu a nang le li-diameter tse nyane ho feta. 2 mm ka mohlala oa orthotopic oa kankere ea mahe a bomme. Re boetse re bonts'a boits'oaro bo ntlafalitsoeng bo itšetlehileng ka li-receptor tsa tlhahiso ea matšoao ka har'a moroto ka mokhoa oa immunocompetent oa metastase ea sebete sa colorectal., le ho kenya tšebetsong li-nanosensors ka har'a li-microarray tsa hlahala ea motho ha li nchafatsoa hape e le li-fluorogenic zymography probes..