Livagen ke peptide ea bioactive ka har'a lelapa la Khavinson; tatelano e khethehileng ea amino acid ke Lys-Glu-Asp-Ala. Lipatlisiso mabapi le ho thibela botsofali le ho phela nako e telele qalong li ile tsa etsa hore e sibolloe.
Multidimensional, thepa e lebisitsoeng ka bongata ke tse ling tsa likarolo tsa eona tse hlokomelehang. Ho etsisa limolek'hule tsa lipontšo tsa endogenous, e sebetsa ka ho toba ka har'a khubu ea sele le mitochondria; taolo e matla ea liphatsa tsa lefutso le ts'ireletso ea cellular ke mesebetsi e hlahisoang.
Kholiso ea histone (H5 le H2A ka ho khetheha) acetylation e manolla libopeho tsa DNA tse hare-hare tse hlokahalang bakeng sa ho nepahala sengoliloeng.
Liphatsa tsa lefutso tse molemo tseo pele li neng li khutsisitsoe kapa li fokotsehile ka lebaka la botsofali li tsosolosoa ho tsosolosa 'bocha ba lisele.’ boemo ba mongolo.
Ho matlafatsa telomerase ts'ebetso le ho fokotsa sekhahla sa telomere nakong ea karohano ke ntlha e 'ngoe ea bohlokoa.
ATP synthesis e ntlafalitsoe, metabolism ea matla le matla ka kakaretso e le sehlahisoa sa ho qetela.
E matla antioxidant mosebetsi, tsamaiso ea methapo ea kutlo tshusumetso, ho ikamahanya le khatello ea maikutlo le boleng ba ho robala kaofela li ameha hantle; homeostasis ke sepheo sa ho qetela sa ketso ea Livagen.
Tatelano
H-Lys-Glu-Asp-Ala-OH
Nomoro ea CAS
/
Foromo ea limolek'hule
C18H31N5O9
Boima ba Molek'hule
461.472
Patlisiso ea Livagen Peptide
1.Epigenetic Regulation le Gene Expression e latelang
Taolo ea Epigenetic ke mokhoa o ka sehloohong oa ts'ebetso bakeng sa lelapa lena la li-peptide.
Acetylation tsa histones (joalokaha ho boletsoe ka holimo) isa ho a chromatin phetoho ea sebopeho ho tloha ho khomphutha haholo ho ea ho e phutholohileng euchromatic naha.
RNA polymerase le lintlha tsa mongolo, ba khona ho ‘kena’ liphatsa tsa lefutso tse neng li sa sebetsanoe pele.
Liteko li bonts'itse liphatsa tsa lefutso tse ngata tse molemo li fetoha tse sa sebetseng liseleng tsa khale ka histone deacetylation.
Livagen e khutlisa ts'ebetso ena, ho seta botjha mananeo a mongolo, ke eona e hlalosang matla a eona a ho thibela botsofali.
2.Telomere Tlhokomelo
Ho khutsufatsoa ha li-telomere ke letšoao la botsofali ba lisele.
Karohano ea lisele ka boeona e baka ho senyeha hona, ha apoptosis e le ntlha ea ho qetela haeba li-telomere li fihla boemong bo bokhutšoane bo tebileng.
Livagen o liehisa sena, mme ka hona e baballa kapa e lelefatsa bophelo ba sele le dithishu.
3.E ntlafalitsoe Mitochondrial Mosebetsi le Bioenergetics
Livagen e matlafatsa tlhahiso ea matla a mitochondrial ka matla.
Ho ntlafatsa ts'ebetso ea mitochondrial ketane ea lipalangoang tsa elektronike ke motheo oa ts'ebetso ena, ka adenosine triphosphate (ATP) kopanyo ho ba sephetho se tobileng.
Joale matla a mangata a cellular a fumaneha; sebopeho sa matla sa mmele ka kakaretso se ntlafala, matla a mmele a latelang ho tloha boemong bona.
Khatello ea mantlha ea ho feteletseng, tlhahiso e bakoang ke khatello ea maikutlo ea mefuta ea oksijene e sebetsang finyelloa – Endogenous endogenous ho boloka matla a bocha ke ntlha ea ho qetela ea mochine ona.
4.Antioxidant le Anti-inflammatory Effects
Livagen e laola lintho tse fapaneng tse sebetsang tsa antioxidant; ho fetola mefuta e kotsi ea oxidative metsoako e se nang kotsi ke ketso ea eona ea mantlha.
Endogenous self-production ke molemo oa 'nete mona, exogenous Antioxidants e sebetsa ho feta likarolo tsohle (bokgabane, pheella, phihlello ya tsamaiso).
Li-membrane tsa lisele, liprotheine, lipids le DNA, amohela ka botlalo, tšireletso ea nako e telele mefuteng eohle ea khatello ea oxidative e bokelletsoeng.
Tšenyo ea limolek'hule e fokotseha ka mekhoa ena.
COA
HPLC
MOF
