Oxytocin ke neuropeptide e entsoeng ka li-amino acid tse robong. Synthesized ka hare ho khubu ea paraventricular (PVN) le khubu ea supraoptic ea hypothalamus, e bolokiloe ka pituitary e ka morao tšoelesa. Ea pele e ile ea sibolloa le ho etsoa ka maiketsetso 1906, temoho ea eona ea setso e le hormone ea bohlokoa ea 'mele e likoloha ho qaleng le ho ts'ehetsa mosebetsi; rhythmic uterine boreleli mesifa e thibelang e le mokhoa o ka sehloohong oa ketso.
Ka mor'a ho pepa mammary gland myoepithelial cell khitla (ho nolofatsa tlhahiso le ho ntša lebese ka mor'a moo) ke karolo e 'ngoe ea bohlokoa e tlalehiloeng hantle. Ho thibela ts'ebetso ea methapo e nang le kutloelo-bohloko, ho fokotsa khatello ea mali le cortisol mahloriso, pholiso ea maqeba le likarabo tsohle tse amanang le ho ruruha ke tlatsetso e eketsehileng ea 'mele e entsoeng ke oxytocin.
Qalong ea lekholo la lilemo, neuroscience e ile ea sutumelletsa tlhaloso ea oxytocin ho ea pele; neuropeptide ea sechaba e hlahile e le tlhaloso e nepahetseng haholoanyane. Mehlala ea liphoofolo e fane ka bopaki bo bongata ba hore oxytocin receptor tlhaloso ea liphatsa tsa lefutso ka ho toba e susumetsa boitšoaro ba sechaba. Maemo a ts'ebetso ea sechaba le a methapo ea kutlo joale a se a bonoa e le karolo ea seo oxytocin 'e se etsang'..
Ho matlafatsa temoho sechabeng, ho tshepana, mefuta e sa tšoaneng ea kutloelo-bohloko le tlamahano e haufi-ufi kaofela li khothalletsoa ke eona. Ho laola khatello ea maikutlo le maikutlo ka ho khetheha, ka khatello ea lefu la hypothalamic-pituitary-adrenal (HPA) axis, bona oxytocin e le molaoli oa bohlokoa.
Clinically oxytocin e nka karolo lits'ebetsong tsa mantlha tsa fisioloji – G protheine li-receptor tse kopantsoeng li ajoa haholo, le litlamorao tsohle tse boletsoeng pejana (pelo le methapo, tsa kelello, kapa ho seng joalo) e ka ba 'me e ntse e lekanngoa e le liphello tse ntle tsa ketso ea eona. Mehato ea kelello bakeng sa mathata a autism spectrum, matšoenyeho a sechaba, Khatello ea kelello ka mor'a ho sithabela maikutlo (PTSD) le ho feta, kaofela li bōptjoa ke 'me ho isa bohōleng bo itseng li hlalosoa ke oxytocin.
Tatelano
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 (Borokho ba disulfide:Cys1-Cys6)
Nomoro ea CAS
50-56-6
Foromo ea limolek'hule
Setšoantšo sa C43H66N12O12S2
Boima ba Molek'hule
1007.19
Lipatlisiso tse amanang le Oxytocin
1.E hlasimollang Tšimoloho ea Popelo
Ho tloha ha e sibolloa, Oxytocin e 'nile ea sebelisoa haholo-holo molemong ona o khethehileng – e tsosang takatso ea popelo, ho theha maemo a matle bakeng sa pelehi. E tlama ho li-receptor tsa oxytocin (mofuta oa G receptor e kopantsoeng le protheine) e lutseng liseleng tsa mesifa ea uterine e boreleli. Ts'ebetso ea tse khethehileng litsela tsa calcium ka hare lera la sele e lebisa ho keketseho e kholo ea khalsiamo ea intracellular ho tsepamisa maikutlo.
Myosin light-chain kinase e ntano kengoa tshebetsong, ho fella ka ho honyela ha morethetho ho boletsoeng ka holimo bonyane ba mesifa e boreleli ea endometrial. Tsena ‘top-down’ contractions closely resemble manually pushing the fetus outward.
Clinical trials have shown intravenous administration to reduce contraction intervals to between 2-3 metsotso; prolongation of duration is also a well documented effect, effective labor contractions being formed thereby. Further research indicates that oxytocin-induced contractions are not merely a facilitative tool in delivery, postpartum rapid vascular closure at the separation site (preventing hemorrhage being one of the more important outcomes) playing a near essential role.
2.Promoting Milk Ejection
Milk ejection depends on the neuroendocrine reflex system, the let-down reflex. Infant suckling the mother’s nipple provides the initial stimulation, nerve endings transmitting said signals to the hypothalamus. Oxytocin is synthesized and released there, ho tsamaea ka har'a mali ho sebetsa liseleng tsa myoepithelial (e potolohileng mammary alveoli le likotopo tse nyane), ho honyela ha bona e le phello ea ho ntša lebese.
Phuputso e 'ngoe e fumane hore boitšoaro ba bakhachane ho litoeba tsa basali bo ile ba hatelloa ka mor'a moo 3 lihora tsa ho itima lijo, ho ntsha lebese le mahlahahlaha ho ba bo bong ba boits'oaro bo hatelletsoeng. Exogenous oxytocin e ile ea tsosolosa boitšoaro bona ka ho feletseng – bopaki bo tobileng ba matla a eona a ho khothalletsa ho ntša lebese.
3.Ho khothaletsa Boitšoaro ba Prosocial
Litšebelisano tsa kahisano ho isa bohōleng bo itseng li thatafalitsoe bokong ba motho. Batho ba baithati ba sebelisa haholo-holo mokokotlo oa orbitofrontal (OFC) ho sebetsana le mefuta eohle ea "boleng ba sechaba", batho ba prosocial ho feta ho amygdala. Kabo e leka-lekaneng ke sephetho sa prosocial se etsahalang ka tlhaho.
Tsamaiso ea Oxytocin e bonts'itsoe ho sutumelletsa batho ba baithati hore ba itšoare ka mokhoa o ikhethileng.
4.Taolo ea pelo le ho Lokisoa ha Mahlaseli
Lefu la pelo ke sesosa se ka sehloohong sa lefu lefatšeng ka bophara. Myocardial infarction liphello tse kholo lefu la cardiomyocyte; khaello e haufi e felletseng ea matla a ho itokisa ka har'a li-cardiomyocyte tsa batho ba baholo e emela tšitiso ea mantlha mofuteng ofe kapa ofe oa ho hlaphoheloa ha pelo..
Ho latela kotsi ea cryogenic lipelong tsa liqoaha, bafuputsi ba hlokometse hore polelo ea oxytocin mRNA e eketsehile haholo bokong, ka lebaka la ho phahama ho tsitsitseng ha oxytocin ka hare ho pelo ka boeona. Thibelo ea lik'hemik'hale ea polelo ena ea oxytocin e hatelletse haholo lits'ebetso tsohle tse lekantsoeng tsa ho lokisa pelo. – ts'ebetso ea lisele tse ncha tsa epicardial ke e 'ngoe ea mehlala e hlahelletseng.
Phuputso ena e bile ea pele ea ho hlalosa ka ho hlaka bohlokoa ba oxytocin, karolo ea ntlafatso bonyane likarolong tse ling tsa tokiso ea lisele tsa pelo.
5.Anti-inflammatory
Ka mefuta e sa tšoaneng ea lefu la pelo le methapo, ho ruruha ho sa feleng ha boemo bo tlase le khatello ea oxidative e amanang le eona ke tšitiso e 'ngoe e haufi le bokahohle ea tokiso e nepahetseng ea lisele. Oxytocin e hatella haholo ho lokolloa le polelo e latelang ea lintlha tse ngata tsa pro-inflammatory, e fokotsa tlhahiso ea lisele tsa 'nete tsa ho ruruha, le ka ho ntlafatsa (endogenous) li-antioxidants joalo ka glutathione peroxidase, e fokotsa likarolo tsohle tsa tšenyo ea oxidative.
6.Ho Laola Takatso ea Lijo le Metabolism
Oxytocin e bapala karolo ea bohlokoa e tlalehiloeng hantle takatsong ea lijo le metabolism e akaretsang. E entsoe ka li-neuron tsa hypothalamic tse hahang haufi le libaka tsohle tsa boko, e hodisa matshwao a ho kgora (boko bo thehiloeng) – tlala e haufi e matla hanghang’ ho ba pheletso ya ho fepa.
Ts'ebetso e tobileng ea tsamaiso ea methapo e bohareng mabapi le dopamine e batlang litsela e fokotsa tšusumetso ea ho batla lijo tsa moputso o phahameng (mafura/ tsoekere ho ba mehlala e meholo). Boithuto bo boetse bo bonts'itse oxytocin ho eketsa insulin ho tsoa pancreatic β-lisele, le ho ntlafatsa glucose homeostasis.
COA
HPLC
MOF
