IiMazduts,ngenye indlela eyaziwa ngokuba yi-IBI362 okanye i-LY3305677, yi-agonist entsha ejolise kuzo zombini i-glucagon-like peptide-1 receptor (I-GLP-1R) kunye ne-glucagon receptor (GCGR). Ukukhonza njenge-arhente echasene nokutyeba, kunciphisa ubunzima bomzimba, iswekile yegazi,ifuthe legazi, kunye nenkitha yezinye iingxaki ezinxulumene nokutyeba.
Uphuhliso lwale khompawundi lwakhiwe phezu kokuqonda okunzulu ngakumbi oxyntomodulin's indima Physiological; Ihomoni yendalo yamathumbu enezinto ezimbini ze-GLP-1 kunye nomsebenzi weglucagon. I-Mazdutide ngokwayo iyi-analog yokwenziwa evela kwi-oxyntomodulin, kunye nokwandiswa i-acyl enamafutha ikhonkco elisecaleni elenzelwe ngokukodwa ukolula ixesha lalo lokusebenza (ivumela dosing kanye ngeveki).
Ngaphandle kokulahleka kwesisindo esilula, uphando lubonise ukuba ivuselela ukukhutshwa kwe-insulin (kwiimpuku), ithoba uric acid amanqanaba, kunciphisa uxinzelelo lwe-oxidative, kwaye inciphisa ngokuyinxenye ngokuqinisekileyo izintso pathologies.
Ulandelelwano
Yakhe-{Ayib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys-{I-AEEA-AEEA-γGlu-Nonadecanoic acid}-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2
Inombolo yeCAS
2259884-03-0
Ifomula yeemolekyuli
C209H319N45O68
Ubunzima beMolekyuli
4563.06
Uphando lweMazdutide
1.Ukuncipha kobunzima kunye nokuNcitshiswa kokutya
Uphononongo lweeveki ezili-12 luvavanye utshintsho kumdla wokutya kunye nobunzima bomzimba kwiimpuku ezilawulwa ngeendlela ezahlukeneyo ze-mazdutide..
Kubalulekile, ukuncitshiswa okuxhomekeke kwidosi kubunzima bomzimba kwabonwa, ngeedosi eziphezulu zisebenza ngakumbi.
Amacandelo e-histological tishu zesibindi anike inkxaso eyongezelelweyo kwesi siphumo – i-hepatic steatosis kunye nokuvuvukala okuhambelanayo kwancitshiswa ngokuphawulekayo.
Mazdutide-HD (ifom yedosi ephezulu) ibonise ezona ziphumo zinamandla ze-hepatoprotective xa kuthelekiswa dulaglutide.
2.Ukuphuculwa koMsebenzi weMoto kunye nokuziphatha okuHlola
Ukulandela 30 iintsuku zolawulo oluqhubekayo, iimpuku eziphathwe nge-mazdutide zibonise ukuphuculwa kwamandla okufunda okucacileyo ngaphezulu kweqela lolawulo, enesiphumo esicacileyo kune dulaglutide.
Iimvavanyo zokuphazamiseka kwengqondo zixhasa umphumo onokubakho wonyango we-mazdutide kumsebenzi wokuqonda.
3.Uphuculo loLungelelaniso lweMoto, Ulungelelwaniso kunye nokuziphatha okuNxulumene nokuxhalaba
Uvavanyo lwe-balance beam lubonise iimpuku ezilawulwa yi-mazdutide ukuba zingcono kakhulu (ixesha lokuwela kunye nezinga lokuphumelela) kuneempuku zolawulo.
Iimvavanyo zokuqonda kunye nokuxhalaba zixhasa ngakumbi ezi ziphumo.
4.Ukuphucula kunye nokulungisa umonakalo weNeuronal kunye nokufa
I kwihippocampus ubandakanyeka ngokusondeleyo ekufundeni nakwinkumbulo; umsebenzi wokuqonda onxibelelene ngokusondeleyo nezi nkqubo.
Ukuqwalaselwa kwe-Histological yamacandelo e-hippocampal neuronal eyonakeleyo ibonisa ukuba i-Mazdutide inciphisa ngokuyinxenye le ndlela yokulahleka kwe-neuronal..
Ukugcinwa kwe-dendritic branching kunye nemilinganiselo eyahlukeneyo yokuxina komqolo kwakhona kwabonwa ngaphakathi kwingingqi ye-hippocampal.; iziphumo ezithile ze-neuroprotective ezibonwa kwi-CA1(uphondo luka-Amon 1) kunye ne-CA3(uphondo luka-Amon 3) Imihlaba engaphantsi inomdla othile.
5.Ukuthintela ukuNcitshiswa kweMyelin
I-Myelination ngokwayo idlala indima ebalulekileyo ekufundeni kweemoto, iimpendulo eziguquguqukayo kuzo zonke iintlobo zeempawu zeemvakalelo ngengxelo eqhubekayo yokusingqongileyo.
Ukugquma kwe-axonal epheleleyo kunye nobukhulu benkxaso yezondlo zenkqubo ye-nervous system zinikezelwa myelin.
Ukuhlaziywa kwe-Myelin (inkqubo edityaniswe ngokusondeleyo kwi-myelination yokwenyani) iyinto kwaye ihlala iyinkalo ebalulekileyo yabantu abadala CNS(Inkqubo yeNervous esembindini) impilo.
I-LFB(Luxol Fast Blue) ukuchaphaza kwavezwa ukuqhawuka komqolo womqolo; iqela le-mazdutide libonise iishethi ze-myelin ezilungelelaniswe ngcono, ukuphelelwa ngamandla kumandla okuba sisiphumo esithe ngqo sonyango.
Ukugcina ingqibelelo ye-myelin ngoku kuthathwa njengento ekujoliswe kuyo enokwenzeka – ukuqala kulibaziseko kunye nokucotha kokuqhubela phambili Isifo sika-Alzheimer ukuba yenye yeenjongo zonyango ezithembisayo zolo phando.
I-COA
HPLC
NKSK
