Babban bincike a cikin hanyoyin jin daɗin rayuwa ya haifar da haɓaka FOXO4-DRI, wani fili senolytic kuma aka sani da IT-Inhibitor peptide. Wannan peptide bioactive yana nuna alamun rigakafin tsufa.
A cikin kwayoyin halitta, misali, FOXO4 yana ɗaure zuwa p53, kafa hadaddun da aka sani da FOXO4-p53 aggregates. Wannan hadaddun yana aiki azaman mai hanawa apoptosis qaddamarwa. Sakamakon haka, wannan hulɗar tana ƙara tsawon rayuwar salon salula kuma yana haifar da tarin su akan lokaci.
Musamman, FOXO4-DRI ba ya kai tsaye ga FOXO1, FOXO3, ko p53 sunadaran. A maimakon haka, yana hulɗa da musamman tare da shafin FOXO4 a cikin hadaddun FOXO4-p53. Wannan haɗin gwiwar yana inganta rarrabuwar hadaddun, nuni p53, kuma ta haka ya sake kunna p53-induced apoptosis, duk yayin da ake kiyaye ƙwayoyin al'ada daga lahani.
Rahotanni da yawa sun nuna tasirin tasirin FOXO4-DRI a cikin zaɓin kashe ƙwayoyin sel.. Bugu da kari, Nazarin ya nuna cewa FOXO4-DRI yana jujjuya raguwar ilimin lissafi da ke da alaƙa da shekaru: yana ƙara ƙarfin jiki da aikin motsa jiki, yana mayar da aikin koda da girma gashi, kuma ta haka yana rage rubewar nama mai nasaba da shekaru. Misali, tsofaffin ƙirar linzamin kwamfuta suna nuna waɗannan fa'idodin a fili. Bugu da kari, FOXO4-DRI yana ragewa na kullum kumburi da lalacewar nama a cikin microenvironment bayan chemotherapy, don haka inganta ingancin rayuwa da inganta lafiyar dogon lokaci a cikin masu fama da ciwon daji.
Jeri
H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D- Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-D-Gly- D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-D-Gly-D-Gly-D-Lys-D-Arg-D-Pro-D-Pr o-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-D-Gly-OH
Lambar CAS
2460055-10-9
Tsarin kwayoyin halitta
Saukewa: C228H388N86O64
Nauyin Kwayoyin Halitta
5358.05
Binciken Fa'idodin Foxo4-dri
1.Gabatarwar Zaɓaɓɓen Senescent Cell Apoptosis
Tsarin farko na FOXO4-DRI ya ƙunshi ƙayyadaddun ƙarfafawa na tsarin mutuwar kwayar halitta a cikin sel masu hankali.. nan, p53 yana aiki azaman abin kunnawa trans-activating don pro-apoptotic genes, haifar da apoptosis. Duk da haka, ƙarƙashin yanayin yanayin ilimin lissafi na al'ada, hadaddun FOXO4-p53 yana danne wannan aikin apoptotic.
Ta hanyar yin takara don ɗaure p53, FOXO4-DRI ya rushe hulɗar FOXO4-p53. Wannan rushewa yana fara hanyar apoptosis na ciki musamman a cikin sel masu hankali.
A cikin tsofaffin beraye, Jiyya tare da FOXO4-DRI ya haifar da haɓakar gashi kwatankwacin berayen masu matsakaicin shekaru da haɓaka aikin motsa jiki sosai..
2.Ingantacciyar Rayuwa ga masu fama da cutar daji
Masu bincike suna binciken FOXO4-DRI a matsayin yuwuwar magani na adjuvant don haɓaka ingancin rayuwa ga masu ciwon daji bayan chemotherapy. Yayin da yawancin maganin ciwon daji ke shafar kwayoyin cutar kansa, suna kuma haifar da rauni mara takamaiman ga sel na yau da kullun, ƙara nauyin jin daɗin jin daɗin jiyya(TIS).
Nazarin da yawa sun tabbatar da cewa FOXO4-DRI na iya kawar da ƙwayoyin jiyya na lokaci-lokaci da kuma jiyya., inganta chemotherapy-jawowa frailty syndrome. Misali, wani bincike a cikin Cell ya nuna ingantaccen farfadowa da rayuwa a cikin berayen da aka yi wa maganin chemotherapy. Waɗannan binciken suna nuna ƙarfin ƙarfin maganin adjuvant na FOXO4-DRI a cikin oncology..
3.Hanta Ciwon Hanta Pathology
A ciki NASH(steatohepatitis mara barasa) marasa lafiya, kwayoyin halitta tara a cikin hanta da ɓoye pro-inflammatory da pro-fibrotic kwayoyin ta hanyar phenotype na sirri mai alaƙa da senescence (SASP), tuki ci gaban cuta. Binciken da aka yi amfani da samfurin NASH na linzamin kwamfuta ya gano cewa FOXO4-DRI ta kawar da waɗannan ƙwayoyin hanta, dakile samar da SASP a tushen sa.
4.Maganin Mice tare da Bleomycin-Induced Fibrosis na huhu
FOXO4-DRI yana haifar da keɓancewar nukiliya na p53 da rarrabuwar hadaddun FOXO4-p53. A cikin nau'ikan linzamin kwamfuta na bleomycin, Jiyya tare da FOXO4-DRI ya rage matakan Collagen, irin I, alfa 1 (Col1a1) da α-SMA a cikin kyallen huhu. Wannan raguwa yana nuna raguwar samar da matrix na waje da hanawa myofibroblast kunnawa.
Kodayake binciken bai ba da cikakken bayani game da madaidaicin hanyar hulɗar FOXO4-DRI tare da p53 ba., a fili ya nuna ingantaccen hana fibrosis, nuna alamar dabarun warkewa mai yuwuwa don idiopathic fibrosis na huhu (IPF).
5.Rage Dangantakar Shekaru Hypogonadism (Rashin ƙarancin Testosterone)
Namiji na farko-farko hypogonadism cuta ce mai alaƙa da tsufa da ke cutar da tsofaffin ƙwayoyin Leydig. Share waɗannan sel masu hankali na iya sake farfado da aikin nama. Nazarin ya nuna cewa FOXO4-DRI yana aiki musamman akan gwajin ɗan adam Kwayoyin Leydig. Gudanar da shi ga tsofaffin beraye ya inganta microenvironment na testicular, hana shekarun da suka shafi testosterone rashi. A 2021 binciken ya ba da rahoton karuwar yawan adadin kwayoyin testosterone a cikin berayen da aka kula da su.
Tsarin da aka tsara ya haɗa da takamaiman dakatarwar p53 na makaman nukiliya da kuma rarraba hadaddun FOXO4-p53., yana haifar da apoptosis-cell. Wadannan sakamakon suna ba da shawarar hanyar da za a iya amfani da su don magance raguwar testosterone mai alaƙa da shekaru.
COA
HPLC
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