Menene KPV peptide：KPV wani peptide na roba ne na roba wanda aka samo daga guntun C-terminal ultra-short tripeptide na faruwa a zahiri. α-Melanocyte-Stimulating Hormone (α-MSH). Bincike a cikin gutsuttsuran α-MSH daban-daban ya jagoranci masana kimiyya don gano cewa takamaiman tsarin C-terminal KPV – wanda ya ƙunshi amino acid guda uku na ƙarshe – yana rasa tasirin inganta melanogenesis; muhimmanci inganta anti-mai kumburi da immunomodulatory Properties, duk da haka, ana riƙe.
KPV kanta yana aiki ta hanyoyin da ba ergoline ba; hana kunna kunnawa da rubutawa na gaba na mahimman abubuwan kumburi shine yanayin farko na aiki. cytokines masu kumburi da yawa suna danne su yadda ya kamata a duka samarwa da fitarwa.
Daidaita takamaiman ƙwayoyin rigakafi (lymphocytes, macrophages da sauransu) wani babban bangare ne na tasirinsa, sake fasalin yanayin yanayin cutar kumburin jiki na ciki. Ana ƙarfafa gyaran ƙumburi kuma an ƙara yawan aikin anti-mai kumburi.
Gwaje-gwaje na asibiti sun nuna ingantaccen ci gaba a ciki gwaji colitis; rage mucosal edema, kariya daga shingen hanji aiki, da nau'i-nau'i daban-daban na gyaran nama/kwayoyin gyare-gyare duk sakamako ne mai iya aunawa.
Ƙananan nauyin kwayoyin KPV wani fa'ida ce mai mahimmanci, yana ba da ingantaccen bioavailability na baka da kuma sanannen ƙarfin sha na transdermal. Gudanar da baka yana ba shi damar tsayayya da lalacewa ta hanyar gastrointestinal enzymes da isa cikin hanji tsarin rigakafi na mucosal kai tsaye.
Jeri
H-Lys-Pro-Val-OH
Lambar CAS
67727-97-3
Tsarin kwayoyin halitta
Saukewa: C16H30N4O4
Nauyin Kwayoyin Halitta
342.44
Binciken KPV Peptide
1.Ayyukan anti-mai kumburi
Wannan shine tsakiya, aikin farko na KPV. Yin niyya ga ainihin lamarin NF-κB a cikin hanyoyin siginar kumburin salula, toshe tsarin kunnawa / juyawa shine abin da ke bayyana aikin sa.
Ana katse bayyanawa da kwafin masu shiga tsakani masu kumburi daga tushe. Hakanan ana haɓaka abubuwan hana kumburi.
Canza yanayin kumburin salula shine ainihin ƙarshen ƙarshen ayyukan KPV biyu.
2.Immunomodulatory Effects
KPV's immunoregulatory ayyuka ya samo asali ne daga aiki mai karfi na anti-mai kumburi. Danne furcin pro-inflammatory M1 genes, wannan aikin yana sauƙaƙe saurin haɓakawa zuwa ga daidaitawar M2 phenotype polarization – wata maɓalli mai mahimmanci a cikin tsarin rigakafi.
Continuous administration of KPV to mice exhibiting inflammatory responses results in the experimental group showing either reduced inflammation, or complete resolution thereof; physiological functions aligning closely with healthy controls.
3.Specific Protective Effects on Inflammatory Bowel Disease (IBD)
Exceptional application value is displayed by KPV in intestinal health.
Mouse models of inflammation show clear improvement of IBD(Inflammatory Bowel Disease) symptoms through oral administration. Intestinal tissue damage, edema, erosions, and inflammatory cell infiltration are all significantly lessened.
Repairing and strengthening the integrity of the mucosal barrier is one of KPV’s primary actions; reduced intestinal permeability follows. Bacteria and their antigens are prevented from translocating across the intestinal barrier, don haka hana wuce gona da iri na tsarin rigakafi a tushen sa.
Warkar da mucosa ita kanta sakamakon wadannan tasirin kariya ne kai tsaye.
4.Inganta Gyaran Nama da Farfaɗowa
Ta hanyar danne kumburi, KPV yana haifar da ingantattun microenvironment na salula don irin wannan gyara ya faru.
Anti-mai kumburi da abubuwan gyara salon salula suna kunna. Nazarin ya nuna haɓakar gyare-gyare da sabuntawa na duka ƙwayoyin epithelial na hanji da ƙwayoyin fata na fata a cikin abubuwan da aka yi wa KPV..
Warkar da rauni, da duk abin da ya biyo baya, wani bangare ne na abin da KPV ke iya cimmawa.
COA
HPLC
MS
