ʻO ka peptide P21 kahi koho nui loa synthetic peptide pūhui me ka pale lolo kiʻekiʻe. Loaʻa mai ka noiʻi nui ma ciliary neurotrophic kumu (CNTF), ʻO CNTF ponoʻī he mea kūlohelohe cytokine i loko o nā neurons; he hana nui kumu neurotrophic.
Ua ʻike nā kānaka ʻepekema, akā naʻe, he paʻakikī ke ʻano CNTF maoli; paʻakikī ke hele i ka pale koko-lolo, immunogenicity pilikia, a ʻo ka hapalua o ke ola pōkole loa e hōʻike nei i nā pilikia koʻikoʻi no ka noiʻi lapaʻau.
Ua alakaʻi ʻia ka ʻike ʻana o kahi ʻāpana kumu, Ac-DGGL-NH₂. Ua hōʻike ʻia nā haʻawina in vitro i kēia ʻāpana i ka nui o ka hana neurotrophic kumu, akā, ua kaupalena ʻia nā mea hiki ke hoʻōla hou aʻe.
ʻO nā mea pilikia nui, ʻo ia ka maikaʻi ʻole o ka pale koko-lolo a kokoke i ka hoʻohaʻahaʻa wikiwiki ʻana e nā protease plasma.; haahaa loa bioavailability in vivo ka hopena hope.
No ka hoʻoponopono ʻana i kēia mau pilikia, kahi ʻano lipophilic tricyclic kiʻekiʻe – ka adamantane ʻāpana – ua hookomoia. Ua hoʻomaikaʻi maikaʻi kēia hoʻololi i ka permeability o P21, keakea steric e hāʻawi ana i ka pale hapa liʻiliʻi o ka N-terminal o ka peptide mai protease hoouka kaua.
Hoʻomaikaʻi ʻia kūpaʻa metabolic a ua hoʻolōʻihi ʻia ka hapalua o ke ola ma muli o ka hopena pololei.
holookoa, ke hoʻokō ʻia nei kahi hoʻonohonoho kūʻokoʻa a wehewehe maikaʻi ʻia o nā hopena neurological a me nā ʻano hana ma o ka hoʻolālā ʻana o P21.
Kaʻina
Ac–asp-gly-gly-leu-adamantane-NH2
Helu CAS
/
ʻĀpana Molekala
C27H41N5O9
Kaumaha Molecular
579.65
P21 Peptide Imi Pili
1.Nā Hana Kūlohelohe o CNTF
Ma waho aʻe o ka hoʻolaha ʻana i ke ola neuron motor, hoʻoulu i nā ʻano like ʻole o ka synthesis neurotransmitter, hoʻoulu i ka ulu ʻana o ka neuronal axon, a me ka pale ʻana i nā neurons a me kā lākou mau mea kākoʻo mai hoʻomāʻewaʻewa a me kekahi mau 'ano o ka poino inflammatory, Hoʻoikaika ka CNTF i nā ala hōʻailona kikoʻī i ka hypothalamus – ʻO ka hoʻonui ʻana i ka māʻona ʻo ia kekahi o nā hopena i kākau maikaʻi ʻia.
2.ʻO ka maikaʻi o ka lāʻau lapaʻau a me nā mea neuroprotective
Ua hōʻike nā hoʻokolohua lapaʻau i ka P21 i ʻoi aku ka maikaʻi o ka hana lāʻau lapaʻau i hoʻohālikelike ʻia me CNTF. Hippocampal neurogenesis, na ano a pau o synaptic plasticity, ʻO ka hiki ke aʻo a me nā ʻano maʻi noʻonoʻo like ʻole i hoʻoikaika maikaʻi ʻia.
Nā hopena neuroprotective (ischemia/reperfusion, neuroinflammation a kaumaha oxidative) ʻike pū ʻia, a hooponoponoia, na P21.
3.Hoʻonui i ka Neurogenesis a me ka hoʻonui ʻana i ka Synaptic Plasticity
Hoʻokumu ʻo P21 i kahi microenvironment maikaʻi no ka hoʻonui, ʻokoʻa, a me ke ola o nā neurons hou.
Hoʻololi i nā ala hōʻailona kikoʻī – HOW/STAT ka mea mua, me kekahi mau hōʻike no MAPK/ERK – ʻo ia ke kuleana no kēia hopena.
Ke hoʻonui nei i ka synaptic plasticity ma o nā hoʻololi maʻalahi i ka 'ikaika’ ʻO nā pilina neuronal kekahi hana nui; pili pono ka mana aʻo me kēia kaʻina hana.
Hōʻike nā hiʻohiʻona holoholona i nā hoʻonui nui i Potentiation lōʻihi (LTP) i loko o nā pūpū hippocampal, ʻO ka hoʻonaʻauao hilinaʻi hippocampus a me nā ʻano hoʻomanaʻo like ʻole e hoʻomaikaʻi ʻia ma muli o ka hopena.
Hoʻonui ʻia ka mālama ʻana i ka cognitive a me ka palaka lolo a puni e P21.
4.Hana Neuroprotective
ʻO ka hoʻoponopono ʻana o nā ʻoihana pale antioxidant intracellular kahi hopena i kākau maikaʻi ʻia.
Hoʻopaʻa i ka hana mitochondrial, ka pale ʻana i kekahi mau ala apoptotic, a me ke kaohi ana (nui loa) ʻO ka neuroinflammation nā mea āpau i kahi kūlana pale.
ʻO ka make neuronal hoʻokolohua simulated – ʻano ischemia-hypoxia, a i ʻole ka maʻi o Alzheimer e hoʻolike ana i nā toxins – hiki ke kaohi pono ia e P21.
ʻO ka mālama ʻana i ka liʻiliʻi o ka ʻāpana neuronal cell integrity ka hopena o kēia laina pale; Ke ʻimi ʻia nei nā ala lapaʻau hou no nā maʻi neurodegenerative maoli.
5.Hoʻoponopono i ka Metabolism Energy a me ka makemake
Ua hōʻike ʻia nā haʻawina lapaʻau mua o CNTF i nā hopena paona ikaika.
Mālama ʻo P21 i ka ʻāpana kumu no kēlā. Hōʻoia nā hoʻokolohua lapaʻau i ka hoʻomau o ka hopena.
ʻO ke ala leptin-STAT3 (hypothalamic) ʻo ia ke kumu o ka noiʻi i kēia manawa; hoʻonui ʻia nā hōʻailona māʻona.
ʻO ke kaumaha o ke kaumaha mai P21 ka mea maikaʻi a, mea nui, mālama ʻiʻo.
Hoʻomaikaʻi pū ka naʻau o ka insulin, ke koi hou aku nei iā P21 i kahi lapaʻau kūpono loa no ka momona a me ka neurodegeneration pili.
COA
HPLC
MS
