Cortagen bụ a tetrapeptide, kpọmkwem Ala-Glu-Asp-Pro, onye otu ezinụlọ Khavinson peptide. Nnyocha miri emi n'ime akụkụ ahụ dị iche iche – thymus, pineal gland, cerebral cortex ịkpọ aha ole na ole – emewo ka ndị ọkà mmụta sayensị kewapụ usoro nke mpụta; Cortagen bụ otu n'ime ndị a mụrụ nke ọma.
Ike, Cortagen nwere ọrụ nhazi usoro ndu nke anụ ahụ. Mgbanwe ziri ezi nke mkpụrụ ndụ ihe nketa (epigenetically ma ọ bụrụ na m na-echeta nke ọma) bụ isi usoro omume ya.
Cortagen n'onwe ya bụ ihe na-eme ihe na-eme ihe ndị a na-achọpụta site na mwepu nke sistemu ụjọ nke etiti. Na-aga n'ihu na njikarịcha na ọrụ nnwale na-esote akwalitela nhazi ya na ebumnuche peptide akọwapụtara maka sistemụ ụjọ..
A eziokwu bioregulator, neuroprotective a na-ahụkwa mmetụta geroprotective. Epigenetic reprogramming nke mkpụrụ ndụ bụ ihe na-akpata uru ndị a – Enwere ike iweghachite mbelata n'ihe gbasara mkpụrụ ndụ ihe nketa afọ, cellular 'epigenetic age’ a na-emezigharị ka ọ bụrụ obere steeti.
A na-enweta mmetụta mgbochi ịka nká site na ọtụtụ usoro a, multi-target synergistic edinam.
Mgbakwunye neuroprotection na neurorepair n'ime Central Nevous System (CNS), tinyere ọrụ ọgụgụ isi, a na-ahụ.
A na-enyochakwa usoro mgbochi na mgbochi obi.
Usoro
Ala-Glu-Asp-Pro
CAS
/
Usoro ihe omimi
C17H26N4O9
Ibu molekụla
430.17 g/mol
Nnyocha metụtara Cortagen
1.Epigenetic Reprogramming:
Ikike pụrụ iche nke Cortagen na mpaghara a bụ isi ihe na-arụ ọrụ ugbu a.
DNA na-adịghị mma na mgbanwe histone okwu na-agbakọta na oge na ndị agadi; A na-abawanye ọrụ mkpụrụ ndụ ihe nketa na-emerụ ahụ, usoro ịka nká gbagoro ngwa ngwa.
Cortagen na-emekọrịta ihe chromatin ogige ndị a kpọtụrụ aha n'elu, na-akpali aberrant steeti azụ ka ọzọ 'nkịtị’ ndị.
Weghachite mbelata mkpụrụ ndụ ihe nketa a kpọtụrụ aha na mbụ bụ njedebe nke omume Cortagen niile – usoro ndu nke ịka nká, na ihe mgbaàmà niile nke obere ma ọ bụ nnukwu ha na-emepụta, na-atụgharị.
Nchekwa Neuro na CNS mbufụt (microglial ma ọ bụ ọzọ) bụ akụkụ nke mgbanwe ndu ahụ.
Iwu a na-enye neurons nwere microenvironment kwụsiri ike ma dịkwa mma maka nlanarị; na-anọchi anya isi ngosipụta nke ọrụ neuroprotective ya.
2.Na-akwalite mmezi akwara ozi na mgbake na-arụ ọrụ:
Ọmụmụ ụdị anụmanụ egosila na Cortagen na-ebelata mmerụ ahụ dị iche iche nke ụbụrụ post-traumatic, na ngwa ngwa ngwa ngwa nke mgbake ọrụ akwara bụ otu n'ime mmetụta ya bụ isi.
Ịgbanwe ụkpụrụ epigenetic bụ ka o si enweta nke a – na-eme ka mmemme mkpụrụ ndụ ihe nketa jikọtara ya na plasticity neural, axonal regeneration, na myelin nhazi.
Mmụba microenvironment cellular dị n'ime ebe mebiri emebi bụ nghọta anụ ahụ nke usoro a; mmezi onwe nke neuronal na mmụgharị na-esochi ya ozugbo.
3.Nkwado na-apụtaghị ìhè maka Sistemụ Obi na Ọrịa Ọrịa:
Nke a epigenetic reprogramming na ụdi 'rejuvenation’ nke mkpụrụ ndụ ihe nketa bụ ihe na-enye ohere nkwado ndị a.
Sistemụ ụjọ na nke ahụ ji alụso ọrịa ọgụ na-ejigide nkwurịta okwu bidirectional nso, nkwụsi ike na microenvironment neural nke a kpọtụrụ aha na mbụ bụ akụkụ buru ibu nke imezu mgbochi homeostasis; nrụgide mpụga niile (ọrịa gụnyere) na-buffered.
Ndị ọzọ na-egbochi ịka nká na mmetụta homeostasis na-achịkwa usoro Cortagen na-arụ ọrụ.
Uru ọtụtụ sistemụ bụ nsonaazụ njedebe – A na-achịkwa akụkụ ndị bụ isi, na arụ ọrụ ahụ dum na-akawanye mma.
COA
HPLC
MS
