Pancragen bụ peptide sịntetik nke na-eme ihe na-eme ihe nke nwere amino acid anọ.
Nnyocha banyere ọrụ pancreatic mere ka ndị ọkà mmụta sayensị chọpụta a homonụ-dị ka ihe na-arụ ọrụ n'ime mpụta nke pancreatic; na-akpali akpali nke pancreas n'onwe ya bụ isi ihe a na-ahụ anya.
Ihe mejupụtara homonụ a amabeghị na mbụ.
Ọganihu na bayoloji ihe omimi na mgbe e mesịrị, nkà na ụzụ njikọ peptide na-enye ohere maka mmegharị ya kpọmkwem – njikarịcha na-aga n'ihu na ngbanwe ezubere iche nke mpempe isi sitere na mbido mbụ bụ ụzọ e si ahazi Pancragen..
Post-synthesis, Ekwuru uru nyocha ụlọ ọgwụ dị ịrịba ama na ya.
Na-eme ka nkwụsi ike nke anụ ahụ pancreatic, na-akwalite mmezi, na ịhazi metabolism homeostasis bụ uru ya bụ isi edepụtara nke ọma.
sara mbara mgbochi mkpali na mmetụta nchebe na-ahụkwa n'ime imeju, akụrụ, usoro ụjọ na akụkụ ndị ọzọ.
Usoro
H2N-Lys-Glu-Asp-Trp-OH
Nọmba CAS
/
Usoro ihe omimi
C26H36N6O9
Ibu molekụla
576.607
Nnyocha nke Pancragen Peptide
1.Nchedo na Mweghachi nke β-cell nke pancreas
Mbelata nke mkpụrụ ndụ ndị a bụ isi ihe na-akpata pathological ọrịa shuga mellitus.
Na-eṅomi ihe uto endogenous ma ọ bụ akara nlanarị, mgbochi nke apoptosis bụ isi usoro; ichebe (opekata mpe nwa oge) mkpụrụ ndụ beta na ịmepụta microenvironment na-akwado maka mmụgharị cell.
A na-edobe ọkwa glucose ọbara kwụsiri ike, na-apụtaghị ìhè site na mma mpụta anụ ahụ insulin uche – ibelata akụkụ dị iche iche nke nguzogide insulin na nkwalite mitochondrial ọrụ.
Pancragen na-arụ ọrụ ụzọ ndụ ndị a kpọtụrụ aha na mbụ (PI3K/Iwu na MAPK/ERK).
Ịmalite ụzọ apoptotic n'okpuru mwakpo mkpali na-egbochi nke ọma.
Ọnwụnwa ụlọọgwụ na-enyocha ugbu a n'ezie mmụgharị ekwentị dị ka ebe njedebe.
Nkewa na-akpali akpali na mmụba nke opekata mpe ụfọdụ sel, jikọtara ya na microenvironment a kpọtụrụ aha na mbụ, na-anọchite anya ngbanwe bụ isi nke ọganihu ọrịa shuga.
2.Iwu Metabolic (dị ka n'elu)
A na-ahụ mmụba nke sistemu insulin n'ụdị anụmanụ.
Cytoprotection na-ebelata ịba ọcha n'anya na anụ ahụ adipose mbufụt na-adịghị ala ala.
Mmetụta ozugbo na nke na-apụtaghị ìhè na onye na-anabata insulin na ọrụ ndị na-ebugharị bụ akụkụ niile nke mmụba zuru oke na mmetụta insulin.
Antioxidant na mmetụta mgbochi mkpali nke Pancragen nwere uru nyocha dị ịrịba ama.
Neuropathy na metabolic syndrome ụdị mmebi, ma ọ bụ ọrịa ọ bụla metụtara nrụgide oxidative, nwere ike ma kwesị irite uru na ngwa ọgwụgwọ Pancragen.
COA
HPLC
MS
