Thymalin(Thymulin) bụ polypeptide bioactive nke zoro ezo thymus anụ ahụ; ewepụtara site na mpụta nke anụ ahụ n'onwe ya. Ọ na-eme kpọmkwem na multi-ezubere iche iji mezie na welie akụkụ dị iche iche nke cellular mgbochi arụ ọrụ n'ime ahụ. Ọ na-akpalite ozugbo T lymphocyte maturation, lymphokine mmepụta, eke egbu egbu cell ọrụ, ma si otú a na-ewusi ike mgbochi ọrịa onyunyo, agbachitere, na ọrụ mkpochapụ.
N'ụlọ ọgwụ, a na-egosi ya maka ịgwọ ụdị dị iche iche ọrịa immunodeficiency – congenital bụ isi ihe atụ, yana chemotherapy kpatara T-cell adịghị arụ ọrụ. Ọganihu dị ịrịba ama na ndị ọrịa’ A na-ahụ ọkwa mgbochi niile, inye nkwado ogologo oge. Na-atụgharị afọ metụtara thymic atrophy na mbelata ọrụ na-esote na-edekwa nke ọma; mweghachi nke ọrụ mgbochi ọrịa bụ kpọmkwem nsonaazụ nke usoro a. Enwere ike ịkwalite nguzogide ọrịa ndị agadi site na iji Thymalin.
Thymalin, dị ka peptide immunomodulatory siri ike, nwere uru bụ isi n'ịkwado homeostasis mgbochi yana ahụike zuru oke.
Usoro
Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH
Nọmba CAS
79621-14-0
Usoro ihe omimi
C33H54N12O15
Ibu molekụla
858.864
Nnyocha nke Thymalin
1.Ọgwụgwọ nke Immunodeficiency
Thymalin na-elekọta ọrịa immunodeficiency dị iche iche enwetara na nke a mụrụ nke ọma. Direct edinam na T lymphocytes (isi 'isi’ sel ndị na-alụso ọrịa ọgụ) bụ isi na mmetụta a.
Ndị ọrịa chemotherapy na-adịte aka na-egosipụta nkwalite ụlọ ọgwụ doro anya na paramita mgbochi ọ bụla enwere ike ịlele. Ike nchekwa, na ruo n'ókè dị ukwuu mma ndụ, na-ebuli elu.
2.Na-akwalite mgbochi n'ime ndị mmadụ ịka nká
Thymus na-enweta mgbanwe dị ukwuu na ndị agadi, na-eduga n'ibelata mmepụta nke homonụ thymic ma mee ka mmepụta T-cell belata. Mbelata iguzogide ọrịa nje dị iche iche bụ nsonaazụ edepụtara nke ọma.
Dị ka ihe nnọchi anya thymic exogenous, Thymalin na-eṅomi microenvironment nke thymic. Ọrụ cell epithelial fọdụrụnụ na-akpali akpali, A na-akwalite ọgbọ T-cell na enwere ike iweghachi akwụkwọ T-cell dị iche iche.
Ịkwalite ọrụ mgbochi ọrịa nke onye merela agadi bụ mmetụta bụ isi; karịsịa akụkụ immunomodulatory na-ekere òkè dị mkpa n'imebi usoro ụfọdụ ịka nká.
3.Ọrịa cancer Usoro ọgwụgwọ adjuvant
Thymalin na-eje ozi dị ka ihe mgbakwunye bara uru na ọgwụgwọ ọrịa kansa zuru oke. Mgbanwe ọtụtụ nzaghachi mgbochi ọrịa megide mkpụrụ ndụ kansa bụ ike na-akọwapụta ya.
Mbelata ụmị ọkpụkpụ site na redio ọ bụla- ma ọ bụ chemotherapy na-ebelata nke ọma, na-eme ka mgbake mkpụrụ ndụ ọbara ọcha ngwa ngwa. CD8+ cytotoxic T cell ọrụ na CD4+ arụ ọrụ na-ebuli elu, imeziwanye nzaghachi mgbochi ọrịa n'ozuzu megide etuto ahụ.
Na-egbochi ọganihu, nlọghachi azụ, na metastasis, Thymalin nwere ike imekọrịta na usoro ọgwụgwọ ọgbara ọhụrụ – A na-emetụta ndụ onye ọrịa na ịdị mma nke ndụ.
Na ọgwụgwọ ọrịa cancer, chemotherapy ogologo oge na-emebi ọrụ mgbochi nke onye ọrịa, na-abawanye ohere maka ọrịa nke abụọ. Imelite ndụ ndị ọrịa kansa bụ isi uru Thymalin na-enye.
4.Ijikwa Ọrịa
A na-agwọkwa ọrịa na-efe efe na-adịghị ala ala nke ọma; na-enyere aka igbochi ọrịa pathogen, Mbelata oge ọrịa na ịgbatị ọgwụgwọ onwe onye mebiri emebi bụ akụkụ nke profaịlụ ọgwụgwọ ya..
5.Na-akwalite Mmezi na Mmegharị Tissue
Omume ụlọ ọgwụ egosila Thymalin iji mee ka ọgwụgwọ dịkwuo ngwa mgbe a wachara ya ahụ, ọkụ, trauma, ọnya, wdg., melite agwọ àgwà, ma belata ọnyà.
Upregulation nke cellular iche ihe na ụzọ uto na-emetụta. Thymalin gosipụtara ikike nrụpụta cell a dị ike.
COA
HPLC
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