Cortagen ke a tetrapeptide, haholo-holo Ala-Glu-Asp-Pro, setho sa lelapa la Khavinson peptide. Lipatlisiso tse tebileng ka litho tse fapaneng – thymus, tšoelesa ea phaene, boko ba boko ho bolela tse mmalwa – e entse hore bo-rasaense ba qolle letoto la likarolo tse qotsitsoeng; Cortagen ke e mong oa ba ithutoang haholo.
E matla, Ts'ebetso ea taolo ea likokoana-hloko e khethehileng e na le Cortagen. Ho feto-fetoha ho nepahetseng ha liphatsa tsa lefutso (epigenetically haeba ke hopola hantle) ke mokhoa oa eona oa mantlha oa ts'ebetso.
Cortagen ka boeona ke ntho ea bioactive e khetholloang ho tsoa litsing tsa tsamaiso ea methapo e bohareng. Ntlafatso e tsoelang pele le mosebetsi oa morao-rao oa liteko o sutumelletse sebopeho sa eona ho lebisa tlhokomelo e khethehileng ea peptide bakeng sa tsamaiso ea methapo..
A 'nete bioregulator, neuroprotective 'me liphello tsa geroprotective lia hlokomeloa. Epigenetic reprogramming ea lisele ke eona motheo oa melemo ena – ho fokotseha ho amanang le lilemo ho polelo ea lefutso ho ka khutlisetsoa morao, cellular ‘ lilemo tsa epigenetic’ ho tloaetsa boemo bo monyane.
Liphello tse khahlanong le botsofali li finyelloa ka tsamaiso ena e mengata, ketso ya dipheo tse ngata tsa synergistic.
Tšireletso e eketsehileng ea neuroprotection le neurorepair ka har'a Sisteme e Bohareng ea Nervous (CNS), mmoho le tshebetso ya kelello, e bonoa.
Ho ntse ho hlahlojoa tsamaiso ea 'mele ea ho itšireletsa mafung le tšireletso ea pelo le methapo.
Tatelano
Ala-Glu-Asp-Pro
CAS
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Foromo ea limolek'hule
C17H26N4O9
Boima ba Molek'hule
430.17 g/mol
Lipatlisiso tse amanang le Cortagen
1.Epigenetic Reprogramming:
Bokhoni bo ikhethang ba Cortagen sebakeng sena ke sepheo sa mosebetsi o mongata oa hajoale.
DNA e sa tloaelehang le phetoho ea histone polelo e bokellana le nako ho batho ba tsofetseng; ts'ebetso e kotsi ea lefutso ea eketseha, mokgoa wa ho tsofala ka potlako.
Cortagen e sebelisana le chromatin mehaho e boletsoeng ka holimo, ho sutumelletsa linaha tse khelohileng ho khutlela ho tse tloaelehileng’ tse ling.
Ho khutlisa polelo ea lefutso e boletsoeng pejana ke pheletso ea liketso tsohle tsa Cortagen – mekhoa ea bophelo ea botsofali, le matšoao ohle a manyane kapa a maholo ao li a hlahisang, li fetotsoe.
Neuroprotection le ho ruruha ha CNS (microglial kapa ho seng joalo) ke karolo ea phetoho eo ea baeloji.
Taolo ena e fana ka li-neurone ka tikoloho e tsitsitseng haholoanyane le e ntle bakeng sa ho phela; e emelang ponahatso ea bohlokoa ea tšebetso ea eona ea methapo ea kutlo.
2.Ho Khothalletsa ho Lokisoa ha Neural le Pholiso ea Ts'ebetso:
Boithuto ba mohlala oa liphoofolo bo bonts'itse hore Cortagen e fokotsa litlamorao tse fapaneng tsa likotsi tsa boko tsa morao-rao, le ho potlakisa ka ho toba ho hlaphoheloa ha methapo ea kutlo ke e 'ngoe ea liphello tsa eona tse ka sehloohong.
Ho fetola taolo ea epigenetic ke kamoo e fihlelang sena – ho kenya tšebetsong mananeo a khethehileng a liphatsa tsa lefutso a amanang le neural plasticity, nchafatso ea axonal, le myelin popeho.
Sebaka se ntlafetseng sa microenvironment ka har'a libaka tse senyehileng ke ho phethahala ha 'mele ha mokhoa ona; ho lokisa li-neuronal le ho tsosolosoa ho latela e le phello e tobileng.
3.Tšehetso e sa Tobang bakeng sa Mekhatlo ea Pelo le ea Tšireletso ea 'mele:
Reprogramming ena ea epigenetic le e latelang ea 'rejuvenation’ ea polelo ea liphatsa tsa lefutso ke eona e lumellang litšehetso tsena.
Tsamaiso ea methapo le ea 'mele ea ho itšireletsa mafung e boloka puisano e haufi-ufi, botsitso ho neural microenvironment e boletsoeng esale pele e le karolo e kholo ea ho fihlella immune homeostasis; likhatello tsohle tsa kantle (lefu le kenyelelitsoe) li buffered.
Litlamorao tse ling tse thibelang botsofali le homeostasis tse laolang li sebelisoa ke Cortagen.
Melemo ea litsamaiso tse ngata ke sephetho sa ho qetela – litho tsa mantlha lia laoloa, le mosebetsi oohle oa 'mele oa ntlafala.
COA
HPLC
MOF
