Pancragen ke bioactive synthetic peptide e entsoeng ka li-amino acid tse 'nè.
Lipatlisiso mabapi le tšebetso ea pancreatic li entse hore bo-rasaense ba sibolle a hormone-joalo ka karolo e sebetsang ka har'a li-extracts tsa pancreatic; ho susumetsa manyeme ka boeona e le phello e ka sehloohong e hlokometsoeng.
Sebopeho se nepahetseng sa hormone ena qalong se ne se sa hlaka.
Tsoelo-pele ho baeloji ea limolek'hule 'me ka mor'a moo theknoloji ea peptide synthesis e ile ea lumella ho ikatisetsa eona hantle – Ntlafatso e tsoelang pele le phetoho e lebisitsoeng ea sekhechana sa mantlha ho tsoa moqomong oa mantlha e le mokhoa oo Pancragen e entsoeng ka eona..
Post-synthesis, boleng ba bohlokoa ba lipatlisiso tsa bongaka bo ne bo bakoa ke eona.
Ho matlafatsa botsitso ba lisele tsa pancreatic, ho kgothaletsa tokiso, le ho laola metabolic homeostasis ke melemo ea eona ea mantlha e tlalehiloeng hantle.
E pharaletseng anti-inflammatory 'me liphello tse sireletsang li boetse li bonoa ka har'a sebete, liphio, tsamaiso ea methapo le litho tse ling.
Tatelano
H2N-Lys-Glu-Asp-Trp-OH
Nomoro ea CAS
/
Foromo ea limolek'hule
Setšoantšo sa C26H36N6O9
Boima ba Molek'hule
576.607
Patlisiso ea Pancragen Peptide
1.Tšireletso le Nchafatso ea Lisele tsa "pancreatic β".
Ho fokotseha ha lisele tsena ke sesosa sa mantlha sa pathological lefu la tsoekere.
Ho etsisa lintlha tsa kholo ea tlhaho kapa matšoao a ho pholoha, Thibelo ea apoptosis ke mokhoa oa bohlokoa; sireletsang (bonyane ka nakoana) lisele tsa beta le ho theha tikoloho e ts'ehetsang bakeng sa nchafatso ea lisele.
Maemo a tsoekere ea mali a tsitsitseng aa bolokoa, ka mokhoa o sa tobang ka lithane tse ntlafetseng tsa peripheral kutloisiso ea insulin – e fokotsa likarolo tse fapaneng tsa ho hanyetsa insulin le ho ntlafatsa mosebetsi oa mitochondrial.
Pancragen e kenya tšebetsong litsela tsa pholoho tse boletsoeng pejana (PI3K/Act le MAPK/ERK).
Ho qala litsela tsa apoptotic tlas'a tlhaselo ea ho ruruha ho thibetsoe ka katleho.
Liteko tsa tleliniki hajoale li ntse li batlisisa ka nchafatso ea 'nete ea cellular e le pheletso.
E susumetsang karohano le ho ata ha bonyane lisele tse ling, mmoho le microenvironment e boletsoeng pejana, e emela phetoho ea mantlha ea tsoelo-pele ea lefu la tsoekere.
2.Taolo ea Metabolic (joalo ka holimo)
Ntlafatso ea tsamaiso ea kutloisiso ea insulin e bonoa mefuteng ea liphoofolo.
Cytoprotection fokotsa sebete le lisele tsa adipose ho ruruha ho sa foleng.
Liphello tse tobileng le tse sa tobang ho insulin receptor 'me mosebetsi oa lipalangoang kaofela ke karolo ea ntlafatso e akaretsang ea kutloisiso ea insulin.
Antioxidant le litlamorao tse khahlanong le ho ruruha tsa Pancragen li bohlokoa haholo lipatlisisong.
Neuropathy le metabolic syndrome tšenyo ea mofuta, kapa lefu lefe kapa lefe le amanang le khatello ea oxidative, e ka rua molemo ho tsoa lits'ebetsong tsa kalafo ea Pancragen.
COA
HPLC
MOF
