Thymalin(Thymulin) ke bioactive polypeptide e hlahisoang ke thymus lesela; e nkiloeng ho tsoa makumaneng ao ka boona. E sebetsa ka nepo le ka mekhoa e mengata ho laola le ho ntlafatsa likarolo tse fapaneng tsa cellular immune tshebetso ka hara mmele. E hlasimolla ka boithatelo T lymphocyte kgolofatso, lymphokine tlhahiso, seleng ea 'molai ea tlhaho mosebetsi, mme ka hona e matlafatsa ho lebela mmele, tshireletso, le mesebetsi ea ho hloekisa.
Clinically, e bontšoa bakeng sa ho phekola mefuta e fapaneng ea mafu a immunodeficiency – congenital ho ba mohlala o ka sehloohong, hammoho le chemotherapy-induced T-cell ho se sebetse. Ntlafatso e kholo ho bakuli’ ka kakaretso maemo a ho itšireletsa mafung a hlokomeloa, ho fana ka tshehetso ya nako e telele. Ho khutlisetsa morao tse amanang le lilemo thymic atrophy 'me ho fokotseha ha ts'ebetso ho latelang ho boetse ho ngotsoe hantle; tsosoloso ea ts'ebetso ea 'mele ea ho itšireletsa mafung ke phello e tobileng ea mokhoa ona. Ho hanyetsa mafu a maqheku ho ka matlafatsoa ka tšebeliso ea Thymalin.
Thymalin, joalo ka peptide e matla ea immunomodulatory, e na le boleng ba mantlha ba ho boloka immune homeostasis le bophelo bo botle ka kakaretso.
Tatelano
Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH
Nomoro ea CAS
79621-14-0
Foromo ea limolek'hule
C33H54N12O15
Boima ba Molek'hule
858.864
Lipatlisiso tsa Thymalin
1.Kalafo ea Immunodeficiency
Mefuta e fapaneng e fumanoeng le ea congenital immunodeficiencies e laoloa ka katleho ke Thymalin. Ketso e tobileng ho T lymphocyte ('moko’ lisele tsa 'mele) ke ea mantlha phellong ena.
Bakuli ba nako e telele ba chemotherapy ba bonts'a ntlafatso e hlakileng ea bongaka maemong ohle a ka lekanyetsoang a 'mele oa ho itšireletsa mafung. Bokhoni ba ho itšireletsa, le ho isa tekanyong e kholo ea bophelo, li ntlafatsoa.
2.Ho Matlafatsa Tšireletseho ea Tšireletso ho Batho ka Botsofali
The thymus e kena ts'ebetsong e kholo ho batho ba tsofetseng, e lebisa ho fokotseng tlhahiso ea li-hormone tsa thymic mme ka lebaka leo e fokotseha tlhahiso ea T-cell. Ho fokotseha ha ho hanyetsa mafu a fapaneng a baktheria ke phello e ngotsoeng hantle.
Joalo ka exogenous thymic signaling agent, Thymalin e etsisa tlhaho ea tlhaho ea thymic microenvironment. Ho susumetsa tšebetso ea lisele tsa epithelial tse setseng, Ho khothaletsoa ho hlahisa T-cell mme ho ka tsosolosoa mokhoa o fapaneng oa T-cell repertoire.
Ho matlafatsa ts'ebetso ea 'mele ea ho itšireletsa mafung ea motho ea tsofetseng ke phello ea mantlha; haholo-holo likarolo tsa immunomodulatory li bapala karolo ea bohlokoa ho loantšeng mekhoa e meng ea botsofali.
3.Kankere Phekolo ea Adjuvant
Thymalin e sebetsa e le tlatsetso ea bohlokoa kalafong e felletseng ea mofetše. Ho fetola likarabo tse ngata tsa 'mele khahlanong le lisele tsa mofetše ke bokhoni ba eona ba ho hlalosa.
Khatello ea moko oa masapo ho tsoa ho seea-le-moea- kapa chemotherapy e fokotsehile ka katleho, ho nolofatsa ho hlaphoheloa ha lisele tse tšoeu tsa mali ka potlako. CD8+ cytotoxic T cell mosebetsi le CD4+ mosebetsi oa ntlafatsoa, ho ntlafatsa karabelo ea 'mele ea ho itšireletsa mafung ka kakaretso khahlanong le lihlahala.
Ho thibela tsoelopele, pheto, le metastases, Thymalin e ka sebelisana le liphekolo tsa sejoale-joale – ho phela ha mokuli le boleng ba bophelo li susumetsoa hantle.
Ka kalafo ea mofetše, chemotherapy e telele e senya ts'ebetso ea 'mele ea ho itšireletsa mafung, ho eketsa monyetla oa ho ba le mafu a bobeli. Ho ntlafatsa boleng ba bophelo ba bakuli ba mofets'e ke molemo o ka sehloohong o fanang ka Thymalin.
4.Ho laola Tšoaetso
Tšoaetso e matla le e sa foleng le eona e phekoloa ka katleho; ho ntlafatsa phallo ea likokoana-hloko, ho khutsufatsa nako ea lefu le ho potlakisa ho ipholisa ha lisele tse senyehileng kaofela ke karolo ea boemo ba eona ba kalafo..
5.Ho Khothalletsa ho Lokisoa le ho Tsosolosa Maqeba
Tloaelo ea tleliniki e bontšitse Thymalin ho potlakisa pholiso ka mor'a ho buuoa, chesa, tsietsi, liso, etc., ntlafatsa boleng ba pholiso, le ho fokotsa maqeba.
Phahamiso ea karohano ea lisele lintlha le litsela tsa kholo lia ameha. Bokhoni bona bo matla ba ho nchafatsa lisele bo bontšoa ke Thymalin.
COA
HPLC
MOF
