Cortagen is a tetrapeptide, specifically Ala-Glu-Asp-Pro, a member of the Khavinson peptide family. Deep research into various organs – the thymus, pineal gland, cerebral cortex to name a few – has led scientists to isolate a series of extracts; Cortagen being one of those more highly studied.
Potent, tissue-specific biological regulatory functions are possessed by Cortagen. Precise modulation of gene expression (epigenetically if I recall correctly) is its primary mode of action.
Cortagen itself is a bioactive substance identified from central nervous system extracts. Continuous optimization and subsequent experimental work have pushed its formulation towards a specific peptide target for the nervous system.
A true bioregulator, neuroprotective and geroprotective effects are observed. Epigenetic reprogramming of cells is what underlies these benefits – age related declines in gene expression can be pushed back, cellular ‘epigenetic age’ being adjusted to a younger state.
Anti-aging effects are achieved through this multi-system, multi-target synergistic action.
Additional neuroprotection and neurorepair within the Central Nervous System (CNS), along with cognitive function, is seen.
Immune system and cardiovascular protection are also being explored.
Sequence
Ala-Glu-Asp-Pro
CAS
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Molecular Formula
C17H26N4O9
Molecular Weight
430.17 g/mol
Cortagen Related Research
1.Epigenetic Reprogramming:
Cortagen’s exceptional capabilities in this area are the focus of much current work.
Abnormal DNA and histone modification expression accumulates with time in aging individuals; harmful gene activity is increased, the process of aging accelerated.
Cortagen interacts with the chromatin complexes mentioned above, pushing aberrant states back to more ‘normal’ ones.
Reversing the earlier mentioned gene expression decline is the end point of all of Cortagen’s actions – biological processes of aging, and all the small or large scale symptoms they produce, are reversed.
Neuroprotection and CNS inflammation (microglial or otherwise) are a part of that biological reversion.
This regulation provides neurons with a more stable and favorable microenvironment for survival; representing a key manifestation of its neuroprotective function.
2.Promoting Neural Repair and Functional Recovery:
Animal model studies have shown that Cortagen mitigates various post-traumatic brain injury sequelae, and direct acceleration of neural functional recovery is one of its primary effects.
Modulating epigenetic regulation is how it achieves this – activating specific gene programs linked to neural plasticity, axonal regeneration, and myelin formation.
The improved cellular microenvironment within damaged areas is the physical realization of this process; neuronal self-repair and regeneration follow as a direct consequence.
3.Indirect Support for Cardiac and Immune Systems:
This epigenetic reprogramming and subsequent ‘rejuvenation’ of gene expression is what permits these supports.
The nervous and immune systems maintain close bidirectional communication, stability in the previously mentioned neural microenvironment being a large part of achieving immune homeostasis; all external stresses (disease included) are buffered.
Further systemic anti-aging and homeostasis regulating effects are activated by Cortagen.
Multi-system benefits are the end result – core organs are regulated, and whole body function is improved.
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