Hexapeptide-1 shine peptide gajeriyar sarkar roba wanda aka ƙera ta hanyar ingantaccen tsari na ɓangarorin endogenous. α-melanocyte-stimulating hormone (α-MSH).
Yana adana ayyukan nazarin halittu na α-MSH, amma yana ƙara kwanciyar hankali da mai karɓa zaɓi tare da maye gurbin amino acid (misali, maye gurbin methionine tare da Nle da kuma gabatar da tsarin D-daidaitacce a matsayin Phe).
Jeri
Nle-Ala-His-DPhe-Arg-Trp-NH2
Lambar CAS
/
Tsarin kwayoyin halitta
Saukewa: C41H57N13O6
Nauyin Kwayoyin Halitta
828.0
Hexapeptide-1 Bincike mai alaƙa
α-MSH muhimmin peptide ne na tsari a cikin vivo, da ƙaramin jerin aiki na "His-Phe-Arg-Trp" da ake buƙata don kunnawa melanocortin masu karɓa (MCRs) an ayyana shi 1.
Hexapeptide-1 wani tsawo ne na babban jerin abubuwan da ke sama wanda aka ƙara Nle da Ala a cikin sa. NH(₂)-ƙarewa, yana haifar da tsarin hexapeptide na masu zuwa: Nle-Ala-His-DPhe-Arg-Trp-NH₂.
Wannan ƙirar ba wai kawai tana riƙe da mahimman jerin sigina ba amma har ma yana ƙaruwa hydrophobicity tare da Nle kuma yana haɓaka kwanciyar hankali na enzymatic ta D-Phe, don haka yana nuna ingantaccen aiki da tsawon rabin rayuwa duka a cikin vitro da in vivo idan aka kwatanta da na ɗan guntu..
Saboda, Hexapeptide-1 shine mahimman kwayoyin kayan aiki don bincika aikin MCR da alamun warkewa masu alaƙa..
Hexapeptide-1 yana aiki galibi akan dangin melanocortin masu karɓa (Saukewa: MC1R, MC3R, Saukewa: MC4R, Saukewa: MC5R).
Daga cikin wadannan, Ana bayyana MC1R sosai a cikin melanocytes na fata, keratinocytes da ƙwayoyin rigakafi kuma shi ne mai karɓa na tsakiya mai sarrafa launin fata, kumburi da shamaki.
(1).Kula da samar da Melanin
A matsayin MC1R agonist, Hexapeptide-1 yana haɗawa zuwa MC1R don kunna adenylate cyclase-cAMP-Hanyar siginar PKA.
Wannan bi da bi yana ƙara yawan aiki na tyrosinase, wanda ke hanzarta haɗawa da jigilar melanin.
Wannan nau'i na biyu yana ba da damar aikace-aikacensa a cikin dalilai na kwaskwarima guda biyu masu adawa da juna: walƙiya fata da takin wucin gadi.
A wuraren da aka danne pigmentation kawai, ana iya amfani da shi don rage haɗarin tabo, lokacin da aka haɗa shi tare da wasu abubuwan walƙiya a ƙayyadaddun ƙididdiga (arbutin da bitamin C).
Matsakaicin amfani, a wannan bangaren, yana taimaka muku samun santsin yanayin sumbatar rana yayin tanning.
(2)Anti-mai kumburi da Modulation na rigakafi
Kunna MC1R kuma yana hana NF-κB hanyoyin siginar kumburi masu alaƙa waɗanda, bi da bi, yana rage samar da abubuwan da ke haifar da kumburi (misali, TNF-a, IL-6) don inganta ja da fushi da UV ko abubuwan da ke haifar da haushi a kan fata.
Bugu da kari, Hexapeptide-1 yana daidaita aikin ƙwayoyin rigakafi da ke zaune akan fata don taimakawa tare da dawo da shingen fata da suka lalace..
Saboda haka ya dace da m fata da bayan hanya gyara kayayyakin.
(3).Farfadowa da Anti-Wrinkle
An nuna Hexapeptide-1 don haɓakawa E-cadherin magana a cikin bincike na baya-bayan nan, wanda ke inganta adhesion tsakanin keratinocytes, kuma yana hanzarta dawo da fata.
A lokaci guda, yana kuma kunnawa fibroblasts a kaikaice ta hanyar hanyar siginar CAMP don haɓaka haɓakar collagen da elastin.
Wannan yana haɓaka elasticity na fata kuma yana rage layi mai kyau, sagging don cimma wasu tasirin rigakafin tsufa.
Hexapeptide-1 shine hadewar ilmin halitta tsarin da dermatology a wurin aiki.
Ta hanyar gyare-gyaren hankali na ainihin jerin abubuwan halitta α-MSH, wannan gajeren peptide tare da haskakawa, anti-kumburi gyara da anti-tsufa multifunctions.
Bincikensa yana ba da madadin kayan kwaskwarimar da ake da su a halin yanzu kuma yana gabatar da sabbin dabaru don magance cututtukan pigmentary., daukar hoto, da kuma ji na fata.
COA
HPLC
MS
