Acetyl Tetrapeptide-15 yog muab los ntawm endomorphin-2 ntawm ib acetylation kev hloov kho ntawm nws lub N-terminal tyrosine seem. Qhov kev hloov kho tshuaj tshwj xeeb no feem ntau yog siv los txhim kho peptide stability lossis hloov nws txoj haujlwm lom neeg.
Endomorphin-2 nws tus kheej yog cov ntaub ntawv zoo endogenous agonist nrog siab affinity thiab selectivity rau cov μ-opioid receptors (MOR) raws li nws txhais cov yam ntxwv. Vim nws cov qauv zoo sib xws rau cov niam txiv compound no, Acetyl Tetrapeptide-15 yog suav tias yog muaj ze li ntawm kev ua haujlwm lom neeg.
Qhov tseem ceeb, thiab mus rau hnub no nyob ze tshwj xeeb, daim ntawv thov ntawm no acetylated peptide ntog hauv kev lag luam tshuaj pleev ib ce – rhiab heev ntawm daim tawv nqaij cov khoom yog cov piv txwv tshaj plaws ntawm nws siv raws li ib tug active ingredient.
Ib ntus
Ac-Tyr-Pro-Phe-Phe-NH2
CAS Nr
928007-64-1
Molecular Formula
C34H39N5O6
Molecular Luj
613.70 g/mol
Kev tshawb fawb ntawm Acetyl Tetrapeptide-15
Txoj kev loj hlob ntawm acetyl tetrapeptide-15 lub hom phiaj txhawm rau txhawb nqa qhov pib ntawm μ-opioid receptor-expressing neurons; endorphin-zoo li txoj kev siv. Txhim kho daim tawv nqaij kam rau ntau yam stimuli sab nraud thiab txo o, mob ntev thiab txawm tias mob neuropathic ntsig txog ntawm daim tawv nqaij hyperreactivity yog qhov xav tau kawg.
1.Modulating CGRP Tso Tawm
CGRP (calcitonin noob ntsig txog peptide) yog ib tug muaj zog pro-inflammatory neuropeptide. Kev hnov mob neurons tso nws, vasodilation thiab tom qab liab / edema yog ob qho kev qhia ncaj qha ntawm qhov rhiab heev.. Cov tawv nqaij rhiab heev thiab cuam tshuam cov lus teb yog qhov tsawg kawg yog ib feem kho los ntawm CGRP.
Ua kom cov TRPV1 receptor (capsaicin, kub, Cov tshuaj depolarizing txhua tus ua haujlwm ua tus tsim) ua rau nws tso tawm. Co-cultured Kev hnov mob neurons kho nrog acetyl tetrapeptide-15 pom tias muaj kev cuam tshuam tseem ceeb ntawm ob qho tib si capsaicin thiab Potassium chloride (KCl, los yog poov tshuaj ntsev) induced CGRP tso tawm – cov nyhuv yog piv rau, los yog zoo dua, Lub npe hu ua TRPV1 antagonist capsazepine.
2.Ua kom cov μ-Opioid Receptors
Nyob rau hauv ib qho kev ntsuam xyuas hauv vitro: Nyob rau hauv lub capsaicin stimulation qauv, acetyl tetrapeptide-15 sib tw ua ke rau μ-opioid receptors ntawm kab lis kev cai neurons. Cov tshuaj opioid antagonist naloxone tau siv los lees paub qhov kev khi no.
Capsaicin nws tus kheej khi rau TRPV1 receptors, ua rau cov calcium nkag; Tom qab CGRP tso tawm thiab qhov mob tshwm sim ua raws li qhov tshwm sim. acetyl tetrapeptide-15 txo qis qhov capsaicin-stimulated CGRP tso tawm, qhov thaiv cov nyhuv ntawm naloxone muab qhov tsim nyog lees paub ntawm kev koom tes receptor.
Ua kom cov μ-receptors tso cai rau acetyl tetrapeptide 15 kom tsis zoo modulate sensory neuron kev ua ub no; pro-inflammatory neuropeptides (CGRP yog ib qho piv txwv tseem ceeb) yog li no tsawg dua. Blocking neurogenic o ntawm nws qhov chaw yog ib qho kev tiv thaiv kab mob kawg, soothing ua lwm yam.
3.Kev tshawb fawb soj ntsuam
Ib qho kev kho qhov muag tsis pom kev sim tshuaj ntsuam xyuas lub peev xwm ntawm acetyl tetrapeptide-15 los txo cov tawv nqaij rhiab heev.. Kev nce ntxiv ntawm cov tshuaj capsaicin tau siv rau hauv nasolabial quav (tsis xis nyob pib yog qhov ntsuas ntawm kev txaus siab), nrog rau contralateral sab plhu ua hauj lwm raws li lub tsheb tswj.
Rov qab siv cov peptide, ntawm 0.0015%, ob zaug ib hnub rau plaub hnub, ua raws li kev sib tw capsaicin ntxiv, pom qhov tseeb thiab ntsuas tau nce hauv qhov pib ntawd.
Tam sim no cov ntawv thov ntawm acetyl tetrapeptide-15 tseem raug kaw rau cov qauv tshuaj pleev ib ce.. Core anti-sensitization yog qhov nws muab; cov khoom siv tawv nqaij (txog hnub tsawg kawg) coj qhov no mus rau hauv tus account.
Hlawv thiab stinging yog txo, thiab mus rau ib qho chaw, txhua hom kev tsis xis nyob los yog ze-normalization ntawm daim tawv nqaij rhiab heev tuaj yeem ua tiav. Cov tshuaj pleev xim tshiab thiab cov tshuaj tiv thaiv kab mob yog cov kauj ruam tom ntej, thiab acetyl tetrapeptide-15 muaj peev xwm nyob rau yav tom ntej dermatological lossis tshuaj pleev ib ce.
COA
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