Adipotide (FTPP ma ọ bụ peptide proapototic) bụ a peptidomimetic ya na usoro amino acid CCGGRAKDC-GG-D (KLAKLAK).
N'ihi nkọwa nhazi ya dị iche, ọ nwere ike ịmata kpọmkwem ma jikọta ndị na-anabata ya abụọ n'elu arịa ọbara n'ime anụ ahụ adipose: Annexin A2 (ANXA2) na prohibitin.
Ọ na-akpali vasoconstriction na apoptosis na-esote na sel ndị a na-anabata ya; arịa ọbara na-akwụsị inye ọbara, oxygen na ihe ndị ọzọ na-edozi ahụ na sel, mmemme cell ọnwụ ịbụ ọgwụgwụ N'ihi.
Usoro a nke ọma na-eme ihe bụ ihe a na-etinye n'ọrụ ozugbo n'ọhịa nke ọnwụ.
Omenala glp-1 analogs ma ọ bụ ndị ọzọ na-eme ihe na-ebelata oke peptides anaghị emeghachi ụdị omume a ozugbo.; adipocytes bụ ebumnuche, apoptosis bụ ụzọ isi nweta mbelata ibu.
Usoro
Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-(dLys-dLeu-dAla-dLys-dLeu-dAla-dLys)2
Nọmba CAS
859216-15-2
Usoro ihe omimi
C111H206N36O28S2
Ibu molekụla
2557.21
Nnyocha nke Adipotide (FTTP)
1.Ngwa ọgwụgwọ enwere ike
Ngwa nwere ike gụnyere – ụdị 2 ọrịa shuga mellitus, ọgwụgwọ ọrịa cancer adjuvant, Mbelata abụba mpaghara mpaghara, ọrịa imeju abụba na-abụghị mmanya.
2.Ọgwụgwọ Ụdị 2 Ọrịa shuga na oke ibu
Nnyocha ndị nọọrọ onwe ha egosila na mgbe ụbọchị asaa nke ọgwụgwọ Adipotide obese oke oke gosipụtara mmetụta insulin ka mma., emelitere polysaccharides ndidi na mbelata ọbara triglycerides.
Mbelata ibu abụghị nke mbụ, ma ọ bụ ọbụna ozugbo, mmetụta ọgwụgwọ.
A 8 Ọmụmụ ọnwa gosipụtara Adipotide ka ọ bụrụ onye na-ahụ maka ọgwụgwọ dị oke mma maka ijikwa oke ibu.
Ụzọ na-apụtachaghị ìhè mana akwadoro maka ụdị ọgwụgwọ 2 A na-emepekwa ọrịa shuga site na usoro nyocha a.
3.Adjuvant Therapy maka Ọrịa Cancer
Ndị ọrịa cancer buru oke ibu nwere ike irite uru na mbelata anụ ahụ adipose (site na vasoconstriction na ozugbo apoptosis) imeziwanye ihe niile sochirinụ chemotherapy nsonaazụ.
4.Mbelata abụba mpaghara
Mbelata abụba mpaghara bụ ụzọ ezubere iche maka njirimara pụrụ iche Adipotide.
Adipotide na-anọchite anya usoro ọgwụgwọ pụrụ iche.
COA
HPLC
MS
