Cartalax bụ peptide sịntetik nke nwere usoro amino acid Ala-Glu-Asp.. E sitere na iberibe protein eke dị n'ime cartilage dị mma, ọ bụ molekul sịntetịt ejiri nlezianya hazie ya.
Usoro amino acid dị iche iche na-eṅomi nke endogenous ụmụ irighiri ihe na-egosi; na-ejikọta ụfọdụ ndị na-anabata cellular, A na-akpalite nzaghachi cellular na-esote.
Nhazi sịntetịk dabara adaba na-enye Cartalax ọrụ ndu dị elu, nkọwapụta, obere immunogenicity, na ezigbo transdermal ma ọ bụ nnabata ọnụ.
Nchọpụta na-aga n'ihu na-akọwapụta ọtụtụ ebumnuche ya, ikike nchekwa na nrụzigharị ọtụtụ ọkwa.
Mbelata mbufụt nke ọma bụ otu ihe si na ya pụta – downregulation nke cytokine pro-inflammatory kpaliri Matrix metalloproteinase (Ndị MMP) na ADAMTS ịbụ usoro izizi; kpọmkwem ozize na mmebi nke ụdị II collagen na dị iche iche proteoglycans na-ebelata, cartilage articular A na-echekwa iguzosi ike n'ezi ihe nhazi.
Ịkwalite ikike nrụpụta nke extracellular matriks bụ usoro omume ọzọ nke nchọpụta ọhụrụ na-atụ aro; chondrocyte A na-emezi ihe nrịbama dị iche iche ma kwalite njikọ ha.
Enwere ike imezi mmebi nke obere cartilage site na ụzọ ndị a, ahụike homeostasis kwadoro.
mgbochi mkpali, Njirimara immunomodulatory na mgbochi ịka nká bụ akụkụ niile nke profaịlụ Cartalax; ule ụlọ ọgwụ na-enyocha ihe niile dị n'elu ugbu a.
Njikọ na ntinye nke Cartalax na-anọchite anya ntụzịaka na-ekwe nkwa nke ọgwụgwọ peptide bioactive.
Usoro
Ala-Glu-Asp
Nọmba CAS
/
Usoro ihe omimi
C12H19N3O8
Ibu molekụla
333.297
Nnyocha nke Cartalax Peptide
1.Mgbochi nke cartilage Catabolism
Dị ka ekwuru, Mgbochi nke oke mmebi bụ isi nke nyocha niile sitere na Cartalax.
Adịghị mma ihe na-akpata mkpali a ga-akwụsịrịrị akara ngosi, na enzymes na-ahụ maka imebi matriks (ọzọ, isi MMPs/Matrix Metalloproteinases) machibido ya ozugbo ma ọ bụ na-apụtaghị ìhè.
Mechanical iguzosi ike n'ezi ihe nke cartilage anụ ahụ bụ njedebe nke ọrụ a niile.
2.Na-akwalite Cartilage Synthesis
Cartalax na-egosipụtakwa ikike pụrụ iche iji kwalite metabolism anabolic anụ ahụ.
Na-akwalite chondrocyte ọrụ ọrụ, ọ na-abawanye ngwa ngwa na njikọ na-esote secretion nke dị iche iche extracellular matrix components; nhazi cartilage kpọmkwem bụ isi njedebe nke usoro a.
Ọmụmụ ihe in vitro akwadola mmetụta a – chondrocytes ma ọ bụ mkpụrụ ndụ steetị a na-emeso na-egosi ọkwa okwu mkpụrụ ndụ dị elu nke ụdị II collagen na aggrecan, na kwekọrọ ekwekọ na-abawanye na n'ezie mmepụta nke kwuru na-edozi.
A na-enweta nkwalite ọzọ na-apụtachaghị ìhè nke metabolism cell na njikọ protein site na ụzọ mgbama intracellular akọwapụtara (TGF-β/Smad ịbụ ezigbo ihe atụ); mmeghari anụ ahụ bụ ihe a chọrọ.
Imezi microdamage dị adị na iwu matriks na-arụ ọrụ bụ ụzọ abụọ bara uru nke usoro ọrụ a kwadoro..
3.Mmetụta mgbochi mkpali na immunomodulatory
NF-κB na-eje ozi dị ka isi mgbama maka ịgbalite ọtụtụ ihe mkpali.
Cartalax na-ebelata nke ọma, ma ọ bụ ma ọ dịkarịa ala na-ebelata, Okwu NF-κB – na-eti isi iyi nke ọtụtụ nzaghachi mkpasu iwe.
Mgbu, ọzịza na isi ike na-adịgide adịgide metụtara mbufụt na-ebelata nke ọma.
Mmetụta nchebe nke cartilage akọwara n'elu bụ akụkụ nke usoro mgbochi mkpali a; ibelata mbufụt bụ akụkụ bụ isi nke usoro ọrụ Cartalax n'ozuzu ya.
COA
HPLC
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