Humanin bụ peptide nke nwere mitochondrial nke nwere ya 24 amino asịd; Achọpụtara na mbụ n'ime nyocha nke ọrịa Alzheimer.
N'ime ndị ọrịa Alzheimer, ikwupụta Humanin n'ime sel ma ọ bụ ịgbakwunye ya dị ka peptide endogenous na-echebe akwara ndị a site na ụdị mmebi dị iche iche metụtara Alzheimer. – mmetụta neuroprotective dị ịrịba ama bụ ihe mbụ a chọpụtara.
Humanin na-arụ ọrụ ụzọ ndụ mkpụrụ ndụ isi, nke JAK2/STAT3/ACT ịbụ isi ihe atụ, na-egbochi ụzọ apoptotic dabere mitochondrial nke ọma; Aβ, ischemia - hypoxia, na otutu ụdị nrụgide oxidative bụ ihe na-akpalite ndị a kpọtụrụ aha.
Ịkwalite antioxidant cellular na ruo n'ókè dị ukwuu ike mgbochi mkpali bụ mmetụta ọzọ edepụtara nke ọma.
Usoro
zutere - Ala - Pro - Arg - Gly - Phe - Ịbụ - Cys - Leu - Leu - Leu - Leu - Thr - Ịbụ - Glu - Ya na - Asp - Leu - Pro - Val - Lys - Arg - Arg - Ala
Nọmba CAS
330936-69-1
Usoro ihe omimi
C119H204N34O32S2
Ibu molekụla
2687.27
Nnyocha metụtara Humanin
1.Ngwa nwere ike ịgwọ ọrịa yana ngwa ụlọ ọgwụ
Ọrụ ndị dị mkpa n'ịkwalite glucose metabolism, imeziwanye ọbụlagodi ụdị ụfọdụ insulin uche, na ichekwa arịa ọbara ka egosiri.
Ya mere, peptide na-echebe endogenous dị ka Humanin nwere ikike dị ukwuu maka ọgwụgwọ (ma ọ bụ na ọ dịghị ihe ọzọ na-emeziwanye) afọ metụtara ọrịa degenerative; Mgbochi ịka nká na usoro ọgwụgwọ Alzheimer a kapịrị ọnụ ka a na-agbaso ugbu a dabere na usoro nyocha a.
2.Ọrụ Nchekwa Metabolic na Vascular
Ọrụ dị mkpa na-akwalite metabolism metabolism, imeziwanye opekata mpe ụdị ụfọdụ nke mmetụta insulin, na ichekwa arịa ọbara ka egosiri.
Ya mere, peptide na-echebe endogenous dị ka Humanin nwere ikike dị ukwuu maka ọgwụgwọ (ma ọ bụ na ọ dịghị ihe ọzọ na-emeziwanye) ọrịa degenerative metụtara afọ; Mgbochi ịka nká na usoro ọgwụgwọ Alzheimer a kapịrị ọnụ ka a na-agbaso ugbu a dabere na usoro nyocha a.
3.Mmetụta Neuroprotective
Mgbochi kpọmkwem nke β-amyloid toxicity bụ ihe na-akọwa ọrụ neuroprotective Humanin. – nchịkọta na ntinye nke Aβ na-esote bụ isi ihe na-ebute ọrịa ahụ.
Onye nnata n'onwe ya na-eme ka ụzọ ndụ intracellular akpọtụrụ na mbụ.
Ihe nrịbama sitere na Humanin na-egbochi ụzọ apoptosis ahụ e kwuru n'elu, a na-ewepụ protein ndị na-egbu egbu; opekempe, a na-egbochi ọnwụ neuronal nke emebere ya.
N'ofe Aβ, degenerative ọrịa akwara ozi (Ọrịa Parkinson, nke Huntington karịsịa) gosi yiri ya, ọ bụrụ na ọ bụghị otu, uru neuroprotective sitere na Humanin.
Nchedo obi na-anọchi anya akụkụ dị mkpa nke uru ọgwụgwọ Humanin.
Mmepe nke Humanin dị ka onye na-ahụ maka ọgwụgwọ na-anọchite anya ọganihu dị mkpa na sayensị ahụike.
4.Mmetụta Antioxidant na Anti-Apoptotic
Isi nke Humanin, Ọrụ bụ isi bụ igbochi apoptosis cell nkịtị nke na-akpata oke nrụgide.
Oke nrụgide oxidative na emesịa ụdị apoptosis a so na isi ihe kpatara ọrịa dị iche iche na ọnọdụ niile metụtara afọ..
Humanin na-akwalite ọrụ nrụgide antioxidant n'ime sel anụ ahụ; na-eguzogide ntọhapụ nke mitochondrial cytochrome C ịbụ akụkụ bụ isi nke usoro a. Usoro a na-enwe ike physiological na-egbochi mmalite nke ụzọ apoptosis dị n'ime, oxidative mmebi bụ isi nchegbu.
Karịsịa, Mmetụta sel nke Humanin na-eme ka ahụ sie ike na-agbatị karịa mkpụrụ ndụ anụ ahụ kpọmkwem – nchebe zuru oke nke nwere akụkụ dị iche iche megide ma oke nrụgide oxidative na ụdị apoptosis niile, bụ ihe Humanin na-enye; a na-ahụta ohere dị ukwuu nke nchebe a.
5.Iwu gbasara anụ ahụ
Humanin na-arụ ọrụ dị mkpa n'ịhazi usoro metabolic homeostasis, nkwụsi ike cellular bụ otu n'ime nsonaazụ ya a na-ahụ anya. Metabolism nke glucose bụ isi ihe atụ.
Nnwale egosila ọkwa dị ala n'ụdị mmadụ 2 ndị ọrịa shuga.
Ịgbakwunye humanin na-akawanye mma nke ọma nnabata glucose; nchebe nke mkpụrụ ndụ β-pancreatic (apoptosis efu) na ndị na-esonụ, insulin dị irè nke nwere njikọ chiri anya.
Usoro ọgwụgwọ ọhụrụ maka ọrịa shuga na ndị metụtara ya ọrịa metabolic syndrome, Humanin na-atụ aro ntuziaka na-ekwe nkwa maka ọgwụ.
COA
HPLC
MS
