Vesugen bụ tripeptide sịntetik nke nwere amino acid atọ (lysine-glutamic acid-aspartic acid, KED). A na-enweta atụmatụ ya site na mgbagwoju peptide dịpụrụ adịpụ site na anụ ahụ vaskụla nke ụmụ anụmanụ na-eto eto, nke na-akwado nrụzi na nhazi ọrụ nke usoro vaskụla, na isi elekwasị anya na ahụike netwọk microvascular. Nnyocha na mmepe nke ụdị peptide bioregulator a dabere na ọrụ emere na St. Petersburg Institute of Bioregulation na Gerontology, iji kwalite vascular homeostasis site n'iṅomi iberibe peptide eke.
Usoro
Lys-Glu-Asp
Nọmba CAS
/
Usoro ihe omimi
C₁₆H₂₇N₅O₈
Ibu molekụla
390.38
Nnyocha nke Vesugen
1.Mmepe na isi mmalite nke Vesugen
Mmepe nke Vesugen sitere na nyocha nke ogige peptide aha ya bụ "Ventfort®", enwetara site na arịa ọbara nke ụmụ anụmanụ na-eto eto. Ndị nchọpụta chọpụtara Vesugen tripeptide n'ime mgbagwoju anya a ma were ya dị ka isi ihe na-arụ ọrụ nke na-ahụ maka ọrụ nchịkwa vaskụla.. Vesugen mechara mechaa kemịkalụ na ịdị ọcha dị elu. Dị ka obere peptide bioregulator, a na-ekwu na ọ na-arụkwa microvessels, melite eruba ọbara, ma na-akwado elasticity vaskụla, si otú ahụ nwee ike igbochi ihe ịrịba ama mbụ nke ịka nká vaskụla.
2.Usoro nke Vesugen na-arụ ọrụ na-agụnye nhazi ọkwa cellular na molecular
(1).Nkwalite nke mmụba cell na ọdịiche
Isi ihe a na-atụ aro maka Vesugen bụ mgbanwe nke mmụba nke mkpụrụ ndụ endothelial vaskụla. Selụ endothelial na-etolite otu oyi akwa na-ekpuchi arịa ọbara, na mmụba ha na mbugharị ha dị oke mkpa maka ịrụzi vaskụla (angiogenesis) na ịnọgide na-enwe iguzosi ike n'ezi ihe nke vaskụla. Nke Ki-67 protein bụ ihe nrịbama nke ọma nke mmụba cell, yana ọkwa okwu ya jikọtara ya na ọrụ mitotic.
Ihe ngosi omimi miri emi nke docking molekụla na-egosi na Vesugen nwere ike jikọta na mpaghara nkwalite nke mkpụrụ ndụ ihe nketa. (MKI67) na-ezochi protein Ki-67, si otú ahụ na-achịkwa okwu ya na epigenetically na-akwalite mmụba cell. Nchoputa a na-enye nkọwa ndu nke ihe omimi nke Vesugen “mmezi nke vaskụla” ọrụ — ya bụ, ịrụzi arịa ndị mebiri emebi site n'ịkwalite mmụgharị nke sel endothelial vaskụla¹.
(2).Iwu nke okwu Gene na steeti Chromatin
Vesugen nwere ike jikọta kpọmkwem na DNA, modulating chromatin conformation na gene transcriptional ọrụ, nke na-emetụta njikọ nke protein dị iche iche metụtara ọrụ vaskụla.
Ọmụmaatụ, ọ nwere ike ibelata okwu nke ihe ndị na-akpasu iwe (dị ka CXCL12) na igbu oge cellular senescence².
(3).Nkwalite nke Angiogenesis na Mgbanwe
Nnwale in vitro na-egosi na Vesugen na-arụ ọrụ nchebe na sel vaskụla, na-eme ka microcirculation dịkwuo mma ma na-eme ka elasticity vaskụla. Mmetụta ndị a jikọtara ọnụ na-enye aka na ike ya maka ịrụzi obere ụgbọ mmiri, na-ebuli usoro ọbara, na ịtụgharị oge ịka nká vaskụla.
Ọ nwere ike banye n'ime oghere site na ndị na-ebu peptide (eg., Pept1 na Lat1), na-emekọrịta ihe na DNA ma ọ bụ histones, mee ka cascades akara ekwentị rụọ ọrụ, ma si otú ahụ kwalite njikọ nke vaskụla elastin ma kwalite microcirculation³.
(4).Mmelite nke nguzogide nrụgide na ike Antioxidant
Vesugen nwere ike imeziwanye nnabata nke akụkụ ahụ na ọnọdụ nrụgide dị ka hypoxia ma belata mmebi oxidative na mkpụrụ ndụ akwara na akwara., nwere ike site n'ịgbanwe ụzọ mgbaàmà intracellular (eg., PI3K/ACT).
3.Mmetụta Neuroprotective na Ngwa sara mbara
Nnyocha na-egosi na Vesugen na-abawanye ọnụ ọgụgụ nke ọkpụkpụ dendritic- jikọtara ya na synapti plasticity - na neurons hippocampal, na-akwadoghị ahụ ike microvascular na mgbaba ọbara nke ụbụrụ cerebral.
Ọmụmụ anụmanụ egosila na Vesugen nwere ike ichekwa neuron ụbụrụ site na mmebi hypoxic.
4.Ngwa ụlọ ọgwụ na ojiji
Ngwa Vesugen na-elekwasị anya na nlekọta ahụike obi na njikwa ọrịa mgbakwunye. A na-atụ aro ya maka ọnọdụ dị iche iche metụtara vaskụla, gụnyere akwara ọbara mgbali elu, vaskụla atherosclerosis, varicose veins, thrombophlebitis, na nsogbu microcirculation mpaghara (eg., ọnya trophic)..
Ọzọkwa, a na-eji ya akwado ọnọdụ ndị metụtara mgbasa ọbara cerebral (dị ka atherosclerosis nke cerebral na sequelae nke ihe mberede cerebrovascular) na maka mgbochi nke afọ metụtara ọrụ vaskụla.
N'ime ngwa ụfọdụ, A na-enyochakwa Vesugen maka ibelata mmetụta nke nrụgide uche-mmetụta mmetụta uche na oke gburugburu ebe obibi na sistem vaskụla¹.
5.Nchịkọta na ọnọdụ dị ugbu a
Vesugen, dị ka onye na-ahụ maka peptide na-elekwasị anya ahụike vaskụla, na-arụ ọrụ site na nhazi ọkwa mkpụrụ ndụ ihe nketa na njikarịcha ọrụ ekwentị. A na-arụ ọrụ ugbu a n'ime usoro ọgwụgwọ bioregulator na Russia na akụkụ Europe.
COA
HPLC
MS
