VIP (peptide intestinal vasoactive, PHM27)
VIP, Mkpirisi maka Vasoactive Intestinal Peptide, bụ neurotransmitter dị mkpa na a peptide na-achịkwa. Ebe ọ bụ na nchoputa ya, mmetụta dị ike na nke dị iche iche nke physiological ọ na-egosipụta ekerewo òkè dị ukwuu na nchọpụta interdisciplinary.; neuroscience, Immunology, na endocrinology bụ ihe atụ kachasị mma.
Achọpụtara nke mbụ n'ime obere mpụta anụ ahụ eriri afọ, Vasodilation bụ ma ka bụ ọrụ a ghọtara na mbụ, na-ebelata ọbara mgbali n'ụzọ dị irè. Ọganihu sayensị na-aga n'ihu ekwela ka njirimara na mezie ọtụtụ ọrụ ndị ọzọ VIP nwere.
Nchọpụta ugbu a na-arụtụ aka na VIP na-arụ ọrụ neuronally ma wepụta ya, na nso nso a eluigwe na ala nkesa na ma Central na mpụta ụjọ usoro. Presence of VIP has even been detected in nerve fibers of multiple systems – respiratory, digestive, urogenital to name a few – all indicating a significant neuromodulatory role.
Multiple vital processes are regulated by VIP, mmụba cell being one example. Neurodegenerative diseases, acute/chronic inflammatory conditions, autoimmune disorders, and even cancer – all benefit from VIP’s current and potential future treatment applications.
Usoro
His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Nọmba CAS
40077-57-4
Usoro ihe omimi
C147H237N43O43S
Ibu molekụla
3326.83
Research Of VIP Peptide
1.Overview of VIP’s Multisystem Physiological Functions
Within the nervous system itself, VIP serves as that all encompassing neurotransmitter; neuroprotection, various types of neuronal survival and differentiation all being regulated by it. Biological rhythms are at least partially controlled by VIP.
Usoro iku ume na-ahụ kpọmkwem VIP modulating bronchodilation (na njikọ pulmonary vasodilation), nkwụsị nke ụfọdụ nzaghachi mkpali, motility nke eriri afọ, gastric acid secretion, mmiri / electrolyte secretion, na izu ike sphincter.
Usoro sistemụ akwara Central na nchekwa akọwapụtara bụ mpaghara ọmụmụ kacha atọ ụtọ a na-achụ ugbu a. Ọmụmụ na ebe nchekwa, ọbụlagodi na akụkụ, a na-akọwapụtaghachi site na mmetụta VIP.
2.Iwu nke iku ume Bronchodilation na mgbochi mkpali mmetụta
N'ime ọrụ ndị mbụ amapụtara, VIP na-egosipụta bronchodilator akpọpụtara na mmetụta vasodilator pulmonary. Na-eme ka ndị na-anabata ya rụọ ọrụ na sel ikuku ma vaskụla dị nro, ọ na-ebuli ọkwa okwu homonụ dị iche iche; A na-emesị kpalie mkpụkọ akwara dị nro, na-ebelata ihe ndị a na-ahụkarị ọbara mgbali elu nke bronchi.
Nnwale ụlọ ọgwụ maka ụkwara ume ọkụ na ọrịa na-adịghị ala ala nke na-egbochi akpa ume egosila VIP iji gbochie mmụba na-adịghị mma na ịkwaga mkpụrụ ndụ akwara tracheal dị nro.; mmụba na ndị ọrịa’ àgwà ndụ, na ọganihu ọrịa ụfọdụ dị nta, bụ nsonaazụ nke omume ndị a kpọmkwem.
3.Iwu nke Ọrụ Sistemụ Digestive
Achọpụtara na mbụ na eriri afọ, VIP na-eje ozi dị ka a enweghị adrenergic, enweghị cholinergic neurotransmitter inhibitory. Ịgbanwe peristalsis intestinal bụ otu n'ime ọrụ ya bụ isi, A na-ejikwa nlezianya na-ahazi ntụrụndụ dị nro; A na-akpali mkpụrụ ndụ epithelial intestinal iji zoo mmiri na ion chloride (mmanu mmanu ịbụ ọgwụgwụ ihe mgbaru ọsọ), gastric acid secretion si sel parietal na-egbochikwa ya.
Idokwa n'ụdị nha nha n'ime usoro nri nri niile bụ ihe VIP na-ahụ maka ya.
4.Mgbanwe mgbochi ọrịa
Dị ka molekul ozi dị mkpa n'ime netwọkụ mgbaàmà endocrine, Ihe mgbochi mgbochi nke VIP, nso-mgbe niile antioxidant, na ọrụ immunoregulatory niile gbara gburugburu na-enwe mmasị dị ukwuu. Mgbochi nke macrophage cytokines pro-inflammatory sitere na ya (na-egbochi mbufụt na isi iyi ma ọ bụrụ na ọ ga-ekwe omume), Mwepụta ihe mgbochi mkpali, na ruo n'ókè T-cell iche iche, bụ akụkụ niile nke ikike ịchịkwa mgbochi ọgụ VIP.
Ọnwụnwa ụlọọgwụ na-enyocha ikike VIP ugbu a n'ọtụtụ ọrịa na-efe efe siri ike ma ọ bụ na-adịghị ala ala.
COA
HPLC
MS
