Livagen is a bioactive peptide within the Khavinson family; the specific amino acid sequence being Lys-Glu-Asp-Ala. Research into anti-aging and longevity initially led to its discovery.
Multidimensional, multi-targeted properties are among its most notable features. Mimicking endogenous signaling molecules, it directly acts on both the cell nucleus and mitochondria; potent gene regulation and cellular protection are the resulting functions.
Promotion of histone (H5 and H2A specifically) acetylation unwinds the tightly coiled DNA structures necessary for proper transcription.
Beneficial genes previously silenced or downregulated by the aging process are reactivated to restore cellular ‘youthfulness’ transcriptional state.
Enhancing telomerase activity and slowing telomere attrition during division is another key aspect.
ATP synthesis is improved, energy metabolism and overall vitality being the end product.
Potent antioxidant activity, neuroendocrine system influence, stress adaptation and sleep quality are all positively affected; homeostasis is the final aim of Livagen’s action.
Sequence
H-Lys-Glu-Asp-Ala-OH
CAS Number
/
Molecular Formula
C18H31N5O9
Molecular Weight
461.472
Research Of Livagen Peptide
1.Epigenetic Regulation and subsequent Gene Expression
Epigenetic regulation is the primary mechanism of action for this family of peptides.
Acetylation of histones (as mentioned above) leads to a chromatin structure transition from highly condensed to a relaxed euchromatic state.
RNA polymerase and transcription factors, are able to ‘access’ previously unengaged genes.
Experiments have shown numerous beneficial genes becoming inactive in aged cells through histone deacetylation.
Livagen reversing this process, re-setting transcriptional programs, is what defines its anti-aging potential.
2.Telomere Maintenance
Shortening of telomeres is a hallmark of cellular aging.
Cell division itself causes this attrition, with apoptosis being the end point if telomeres reach a critically short state.
Livagen delays this, and as such preserves or extends the life of the cell and tissue.
3.Enhanced Mitochondrial Function and Bioenergetics
Livagen powerfully optimizes mitochondrial energy production.
Enhancing the efficiency of the mitochondrial electron transport chain is at the core of this process, with adenosine triphosphate (ATP) synthesis being a direct result.
More abundant cellular energy is then made available; the body’s overall energy structure is improved, organism vitality subsequently following from this state.
Fundamental suppression of the excessive, stress-induced production of reactive oxygen species is achieved – endogenous momentum towards maintaining youthful vitality is the end point of this mechanism.
4.Antioxidant and Anti-inflammatory Effects
Livagen upregulates various antioxidant active substances; converting harmful oxidative species into harmless compounds is its primary action.
Endogenous self-production is the true advantage here, exogenous antioxidants being outperformed in all aspects (efficiency, persistence, systemic reach).
Cell membranes, proteins, lipids and DNA, receive comprehensive, long term protection from all forms of accumulated oxidative stress.
Molecular damage is reduced by these processes.
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