What is KPV peptide：KPV is a synthetic bioactive peptide derived from the C-terminal ultra-short tripeptide fragment of naturally occurring α-Melanocyte-Stimulating Hormone (α-MSH). Research into various α-MSH fragments led scientists to discover that the specific C-terminal sequence KPV – comprising those very last three amino acids – loses its melanogenesis promoting effect; significantly enhanced anti-inflammatory and immunomodulatory properties, heoi ano, are retained.
KPV itself acts through non-ergoline mechanisms; inhibition of the activation and subsequent transcription of key inflammatory factors being the primary mode of action. He maha nga cytokines pro-inflammatory ka tino pehia i roto i te whakaputa me te tuku.
Te whakarerekētanga o ngā pūtau ārai mate motuhake (lymphocytes, macrophages i roto i etahi atu) Ko tetahi atu waahanga nui o tona paanga, te whakahou i te taiao anti-inflammatory o roto o te tinana. Ka whakaihiihihia te whakatikatika i te mumura, ka piki ake te mahi anti-inflammatory.
Kua whakaatuhia e nga whakamatautau haumanu te whakapai ake i roto colitis whakamatautau; whakaheke edema mucosal, tiaki o arai intestinal mahi, me te maha o nga momo whakatikatika i te kiko/te taumata o te pūtau he putanga katoa ka taea te ine.
Ko te iti o te taumaha ngota o te KPV tetahi atu painga nui, e tuku ana i te pai o te koiora-waha me te kaha o te whakauru transdermal. Ka taea e te whakahaere a-waha te aukati i te paheketanga e te gastrointestinal whākōkī ka tae ki te whekau pūnaha ārai mucosal tika.
Raupapa
H-Lys-Pro-Val-OH
Tau CAS
67727-97-3
Tātai rāpoi
C16H30N4O4
Taumaha rāpoi
342.44
Rangahau o KPV Peptide
1.Mahi Anti-inflammatory
Ko te pokapū tenei, mahi tuatahi a KPV. Te aro ki te take matua NF-kB i roto i nga huarahi tohu mumura pūtau, ko te aukati i te mahi whakahohe/whakawhitinga te mea e tohu ana i tana mahi.
Ka haukotia te whakapuakitanga me te tuhi o nga takawaenga pro-inflammatory i te puna. Ka whakatairangahia ano hoki nga ahuatanga anti-inflammatory.
Ko te whakarereke i te taiao mumura pūtau he tino mutunga o nga mahi ture rua a KPV.
2.Nga Painga Immunomodulatory
Ko te mahi immunoregulatory a KPV i ahu mai i tana mahi anti-inflammatory kaha. Te pehi i te whakaaturanga o nga ira M1 pro-inflammatory, Ko tenei ngohe ka tere ake ki te whakatikatika i te M2 phenotype polarization – he tikanga whakahaere matua i roto i te punaha mate.
Ko te whakahaere tonu o te KPV ki nga kiore e whakaatu ana i nga urupare mumura ka puta mai i te roopu whakamatautau e whakaatu ana i te iti o te mumura., te whakaotinga ranei o taua mea; nga mahi whaiaroaro e hono tata ana ki nga mana hauora.
3.Nga Paanga Tiaki Motuhake i runga i te mate mumura o te whekau (IBD)
Ko te uara tono hirahira e whakaatuhia ana e KPV i roto i te hauora intestinal.
Ko nga tauira kiore o te mumura e whakaatu ana i te whakapai ake o IBD(Ko te mate pukupuku o te whekau) nga tohu ma te whakahaere waha. Te kino o te kiko whekau, edema, horonga, me te whakaurunga o nga pūtau mumura ka tino iti haere.
Ko te whakatikatika me te whakapakari i te tapatahi o te arai mucosal tetahi o nga mahi tuatahi a KPV; ka heke te uruhanga intestinal. Ko nga huakita me o raatau antigens ka aukati i te whakawhiti puta noa i te arai intestinal, na reira ka aukati i te whakakorikoritanga o te punaha mate i tona take.
Te whakaora i nga mucosa ko te hua tonu o enei paanga whakamarumaru.
4.Te Whakatairanga i te Whakapai me te Whakahoutanga o te Tissue
Ma te pehi i te mumura, Ka hangaia e KPV he taiao moroiti pūkoro pai ake kia puta ai taua whakatikatika.
Ka whakahohehia nga ahuatanga anti-inflammatory me te hanga pūtau. Kua whakaatuhia e nga rangahau te tere o te whakatikatika me te whakaoranga o nga pūtau epithelial intestinal e rua me nga pūtau epidermal kiri i roto i nga kaupapa kua tukinotia e te KPV..
Te whakaora i nga patunga, me nga mea katoa e whai ake nei, he wahanga o nga mea ka taea e KPV te whakatutuki.
COA
HPLC
MS
