NA Semax Amidate

Rangahau o NA Semax Amidate

Ko te NA Semax Amidate e whakaatu ana i te whai huatanga e rite ana ki te puāwaitanga anxiolytic raau taero i roto i te maha o nga tauira preclinical.

1.Te Whakanui Hinengaro me te Neural Plasticity

NA Semax Amidate ka whakahohe i te take tuhi CREB, whakatikatika BDNF whakaaturanga ira me te whakanui ake i nga taumata BDNF neuronal i runga ake 40%.

Ma tenei ka whakatairanga tuawhenua dendritic hangahanga, aratohu axonal, me te whakahiato o te pūmua kiato postsynaptic 95 (PSD-95), na reira ka whakarei ake i te kaha ako.

Ko nga whakamatautau whakataihanga koiora e whakaatu ana i a 35-50% te whakapai ake i nga reiti pupuri mahara i roto i te horopaki whakamau wehi whakamātautau.

Porohia roro electrophysiological ka whakapumautia nga rekoata kua piki ake LTP kaha kaha me te roa, e tohu ana ka huri ano te NA Semax Amidate te kirihou synaptic paepae na roto i te whakahoaho hohonu o te tauwehe neurotrophic whatunga.

2.Neuroprotection me te Whakatikatika

NA Semax Amidate ka whakahohe i te adenylate cyclase (AC)-ara cAMP-PKA ki te whakau mitochondrial te kaha membrane, te aukati cytochrome C tuku, me te pehi caspase-3 whakahohenga cascade, na reira ka aukati i te wahanga mahi o apoptosis.

I te wa kotahi, ka whakatika superoxide dismutase te whakapuaki me te aukati i te mumura nui cytokine hangahanga.

I roto i te kiore te uaua o waenganui tauira occlusion, i iti iho mate roro rōrahi i runga 50%.

I roto i tetahi MPTP tauira o te mate Parkinson, i nui haere dopaminergic ora neuron e 35%, e whakaatu ana i te neuroprotection kaha.

3.Anxiolytic and Analgesic Pānga

Ko te NA Semax Amidate ka whakanui ake i te hononga mo te mutunga enkephalins a β-endorphin i te aukati G kinase receptor-honoa pūmua (Kariki)-takawaenga o roto o te kaiwhiwhi me te whakaheke, na reira ka whakaroa whakamaroke tohu tohu.

Ka whakahekehia ano hoki e te FTO-mediated inflammatory pain hypersensitivity.

I roto i nga tauira kiore, paepae mamae i whakanuia e 30-40% a ka noho teitei mo 4 ki 6 haora.

I roto i te whara constriction mau tonu (CCI) tauira, miihini allodynia i whakaitihia e 50%, me te whakapumau i nga ahuatanga o te NA Semax Amidate me te whakapumau i nga ahuatanga.

Ko te NA Semax Amidate e whakaatu ana i te kaha e rite ana ki nga raau taero anxiolytic puāwaitanga i roto i nga tauira preclinical..

4.Te Whakanui Hinengaro me te Neural Plasticity

NA Semax Amidate ka whakahohe i te take tuhi CREB, te whakatikatika i te whakaaturanga ira BDNF me te whakanui ake i nga taumata BDNF neuronal 40%.

Ma tenei ka whakatairanga i te hanganga o te tuara dendritic, aratohu axonal, me te whakahiato o te pūmua kiato postsynaptic 95 (PSD-95), na reira ka whakarei ake i te kaha ako.

Ko nga whakamatautau whakataihanga koiora e whakaatu ana i a 35-50% te whakapai ake i nga reeti pupuri mahara i roto i nga whakamatautau whakamaarama mataku.

Ko nga rekoata electrophysiological tapatapahi roro e whakau ana i te pikinga o te kaha kaha me te roa o te LTP, e tohu ana ka whakahouhia e NA Semax Amidate nga paepae kirihou synaptic na roto i te whakahoahoatanga o te whatunga tauwehe neurotrophic..

5.Neuroprotection me te Whakatikatika

NA Semax Amidate ka whakahohe i te adenylate cyclase (AC)-ara cAMP-PKA ki te whakapumau i te pumanawa membrane mitochondrial, ka aukati i te tuku cytochrome C, me te pehi i te caspase-3 cascade activation, na reira ka aukati i te wahanga mahi o te apoptosis.

I te wa kotahi, ka whakatika i te whakaaturanga superoxide dismutase me te aukati i te hanga cytokine inflammatory nui.

I roto i te tauira occlusion cerebral artery kiore waenga, i whakaitihia te nui o te mate o te roro 50%.

I roto i te tauira MPTP o te mate Parkinson, nui haere te reira dopaminergic neuron ora e 35%, e whakaatu ana i te neuroprotection kaha.

6.Anxiolytic and Analgesic Pānga

Ko te NA Semax Amidate ka whakanui ake i te hononga mo nga enkephalins endogenous me te β-endorphin i te wa e aukati ana i te kinase receptor-hononga G. (Kariki)-takawaenga o roto o te kaiwhiwhi me te whakaheke, na reira ka roa te tohu analgesic.

Ka whakahekehia ano hoki e te FTO-mediated inflammatory pain hypersensitivity.

I roto i nga tauira kiore, i whakanuia nga paepae mamae e 30-40% a ka noho teitei mo 4 ki 6 haora.

I roto i te whara constriction mau tonu (CCI) tauira, i whakaitihia te allodynia miihini e 50%, me te whakapumau i nga ahuatanga o te NA Semax Amidate me te whakapumau i nga ahuatanga.