Antecedent cellular mechanisms
The essence of human aging is cellular senescence, senescent cells forever out of the cell cycle, but they will not be removed as directly as apoptotic cells, senescent cells generally have a large number of damaged DNA, which may be the reason why they are not removed, so the senescent cells will be a large number of retained, and continue to be deposited thereby inducing the body’s aging and the occurrence of related diseases. (Before senescent cells kill you, you should strike first)
The p53 gene has the function of inducing apoptosis, and its mechanism is that the p53 protein encoded by the p53 gene functions as a checkpoint in the G1 phase of the cell cycle and is responsible for checking whether there is any damage to the chromosomal DNA; once the defective DNA is found, it stimulates the expression of CIP, which prevents the cells from entering into the cell cycle and initiates the mechanism of DNA repair; if the repair fails, the p53 initiates the apoptosis mechanism.
ja ya células senescentes, FOXO4 expression rises and affects the process of cellular senescence and apoptosis through interaction with proteins such as p53. Because it attaches to p53, it can prevent senescent cell death.
Difference between FOXO4 and FOXO4-Dri
FOXO4 short peptide is L-type amino acid.
FOXO4-Dri short peptide is D-type amino acid.
Why FOXO4-Dri appears
FOXO4 ge 'nar polipéptido cadena recta compuesto ya 46 aminoácidos, ar Nar dätä hño kasu̲ nga̲tho ar secuencia ar aminoácidos ar klase D, ngetho combina ko ar gen p53, nu'bu ar hmä ar gen p53, nja'bu̲ bí lleva ar incapacidad pa da hñäki ya células senescentes.
ja ar idea original, ya científicos mi ne nda utilizar edición genética pa ju̲ts'i ar gen foxo4, pe nuna bí 'me̲fa 'be̲fi ne propenso da ngi ar ADN. Therefore, ya científicos idearon 'nar 'na ar mpa̲ti reemplazando ga̲tho ya aminoácidos ar klase L jar péptido corto FOXO4 ko ar aminoácidos ar klase D, da invierte ar conformación FOXO4 — Dri ne ar une competitivamente ma p53, mente da mä 'met'o da FOXO4 ar mfats'i da p53.
P53 activa proteínas apoptóticas ne causa muerte celular. eliminando ya células viejas ar tejido, ar tsa̲ da dähä ar regeneración ar tejido mäs dramática.
Attachment: senescent mice injected with FOX04-dir showed significant improvement in kidney function and hair began to repair itself.
