Liphetoho tsa Peptide
Li-peptide tse monate
Chelating Peptides ke eng?
Ho kopanya li-peptide ho li-chelator tsa tšepe (mohlala. DOTA, SEBELISA, etc.) e fana ka mokhoa o khahlehang oa ho nahana ka lisele tsa mofetše kapa liphekolo tse tsamaisang li-oncotoxin ho lisele tsa mofetše. Li-interleukin 13 pontšo ea molek'hule alpha 2 (IL13RA2) ke molek'hule e tšoaeang e hlahisoang haholo ho li-glioma tse kotsi (GBMs) empa ha e eo liseleng tse tloaelehileng. Ho lebisa li-ligand tse tlamang molek'hule e joalo ea pontšo ho ka fana ka mokhoa o mocha oa ho phekola li-gliomas tse kotsi. (GBMs). Hobane IL13RA2 e tlameletsoe ho IL13, molek'hule ena e bonts'ang ke sepheo se khahlang liphekolong tse fetisetsang limolek'hule tsa cytotoxic tsa mofetše ho glioma e mpe. (GBMs) lisele.Peptide-1 linear (Pep-1L) e hlahlobiloe bakeng sa bokhoni ba eona ba ho tlama IL13RA2 ka mokhoa o lebisitsoeng, le ka liphetoho tsa chelating, mofuta oa Peptide-1 (Pep-1L) e ka tsamaisa cytotoxin Actinium-225, Ac-225, ho malignant glioma (GBMs) lisele.
Tšebeletso ea Chelating Peptides
Lethathamo le Tloaelehileng
Polelo kapa maikutlo a feteletseng a limolek'hule tse ikhethang tsa lisele tsa mofetše li lebisitse ho nts'etsopele ea peptide synthesis e ka lebisang limolek'hule tsena tse bontšang matšoao., le MOL Changes e fana ka mefuta e mengata ea liphetoho tsa peptide chelator, ho kenyelletsa DOTA le DTPA.
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khutsufatsa
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Mabitso a felletseng
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DOTA |
1,4,7,10-tetraazacyclododecane-N,N,N,N-tetraacetic acid |
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SEBELISA |
1,4,7-triazacyclononane-N,N,N-triacetic acid |
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MOHLAKANE |
1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid |
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DTPA |
asiti ea diethylenetriaminepentaacetic |
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IDA |
Asiti ea Iminodiacetic |
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CB-TE2A |
4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane |
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DiAmSar |
1,8-Diamino-3,6,10,13,16,19-hexaazabicyclo[6,6,6]-eicosane |
Litlhaloso tse hlahang
Litlhaloso tse Ncha mabapi le Moralo oa Li-Peptide tsa Bioactive le Li-Chelating Agents bakeng sa ho Imaging le Therapy ho Oncology.
Li-peptide tse ngata tsa maiketsetso li entsoe bakeng sa tlhahlobo le kalafo ea mofets'e oa batho ho ipapisitsoe le bokhoni ba bona ba ho shebisisa li-receptor tse itseng holim'a lisele tsa mofetše kapa ho kenella ka har'a membrane ea lisele.. Liphetoho tsa lik'hemik'hale tsa liketane tsa amino acid li ntlafalitse ts'ebetso ea tlhaho haholo, botsitso le katleho ea li-analogues tsa peptide tse sebelisoang hajoale e le lithethefatsi tse thibelang mofetše kapa li-tracers tsa litšoantšo tsa limolek'hule.. Ho tsitsa ha somatostatin, li-integrin le li-analogue tsa bombesin 'meleng oa motho li eketsehile haholo ka ho palama le / kapa ho kenngoa ha li-amino acid tseo e seng tsa tlhaho tatellanong ea peptide.. Ho feta moo, ka kakaretso thepa ea pharmacokinetic ea li-analogues tse joalo le tse ling (ho kenyelletsa cholecystokinin, vasoactive intestinal peptide le neurotensin analogues) li ntlafalitsoe ke PEGylation le glycosylation. Ho feta moo, khokahanyo ea li-analogue tsa peptide ho lihokela tse ncha le li-chelator tse sa sebetseng hantle (joalo ka AAZTA, MOHLAKANE, SEFABA, NUMBER joalo-joalo), e hlahisitse lihlopha tse nang le radiolabeled tse nang le halofo ea bophelo bo eketsehileng le kamano e phahameng e tlamang ho li-receptor tsa cognate. Tlhahlobo ena e hlalosa liphetoho tsa bohlokoa ka ho fetisisa le tsa morao-rao tsa lik'hemik'hale tse hlahisitsoeng ka tatellano ea amino acid hammoho le li-linkers le li-chelator tse ncha tse sa sebetseng tse ntlafalitseng haholo ho khetheha le kutloisiso ea li-peptide tse sebelisoang ho hlahloba le ho phekola oncologic..
Litšebeletso tse Amanang tsa Phetoho ea Peptide
glycosylation ea peptide
glycosylation ea peptide
Peptide glycosylation ke phetoho e kopanetsoeng e ka ntlafatsang thepa ea physicochemical ea peptide.
Bala haholoanyanePhosphorylation ea peptide
Phosphorylation ea peptide
Phosphoralation e ka hlaha ka Serine (S, Ho ba), Threonine (T, Thr) le Tyrosine (Y, Tyr) liketane tse mahlakoreng ka ho theha bond ea phosphoester
Bala haholoanyaneLi-peptide tse tloaelehileng
Li-peptide tse tloaelehileng
Kenyelletso ea li-amino acid tse peli tseo e seng tsa tlhaho tse nang le α-methyl, lihlopha tsa α-alkenyl nakong ea motsoako o tiileng oa liketane tsa peptide.
Bala haholoanyanePeptide ea cyclic
Peptide ea cyclic
Peptide cyclization e ntlafatsa botsitso ba li-peptide (e amanang le li-analogue tsa bona tsa mela) 'me ke leano le tloaelehileng ho nts'etsopele ea peptide.
Bala haholoanyanephetoho ea peptide
Boiphihlelo bo pharalletseng ba phetoho ea peptide, ho fana ka mekhoa e mengata e sebetsang ea lipatlisiso tsa peptide.
