Boitokisetso le tlhahlobo ea pele ea baeloji ea n-Gluc-Ls([Al18 F]SEBELISA)-TOCA

Octreotide le lihlahisoa tsa eona li ka tlama ka ho khetheha le somatostatin receptor (SSTR) eo hangata e hlalosoang ka ho fetelletseng liseleng tse ngata tsa hlahala. Kahoo 18F e ngotsoeng octreotide le lintho tse tsoang ho eona e ka sebelisoa bakeng sa tlhahlobo le tlhahlobo ea katleho ea kalafo ea lihlahala tse ntle tsa SSTR.. Bakeng sa ho hlahloba phuputso e ncha ea PET bakeng sa tlhahlobo ea lihlahala tse ntle tsa SSTR, N-Gluc-Lys([Al18F]SEBELISA)-TOCA e ne e entsoe ka seea-le-moea ka potlako le ka nepo e sebelisa karabelo ea chelation ea n-Gluc-Lys.(SEBELISA)-TOCA e nang le sehlopha sa Al18F, n-Gluc-Lys([Al18F]SEBELISA)-TOCA e ne e le motsoako oa glycosylated octreotide o kopantsoeng le 1, 4, 7-triazacyclononane-1, 4, 7-asiti ea triacetic(SEBELISA). Ts'ebetso e ntle ea ho ngola ea n-Gluc-Ls([Al18F]SEBELISA)-TOCA ke 69% 'me nako eohle ea ho kopanya ke 25-30 min. Ho hloeka ha radiochemical ho felile 95% ka mor'a tlhoekiso ea kholomo ea HLB. The stability in vitro e ntle haholo, mme hydrophilicity e phahame (lg P = -4.20 ± 0.09(n = 3)). Lithuto tsa biodistribution ho litoeba tse tloaelehileng ho 2 h ka mor'a ente e bontša hore ho nkoa ha n-Gluc-Ls([Al18F]SEBELISA)-TOCA ka liphio e phahame ((13.83 ± 3.52)% ID/g(n = 5)) mme sebete le lesapo la kokota di fokotsehile. Keketseho ea "samatostatin pancreas receptor Express" e phahame haholo, 'me semelo sa mali le mesifa se tlaase. Liphetho tsena tsa pele li fana ka motheo oa liteko bakeng sa thuto e tsoelang pele ea Al18F complex e ngotsoeng octreotide le li-analogue tsa tsona e le lipatlisiso tsa tumor bakeng sa ho fumanoa ha SSTR-positire tumors.. (bangodi)