Acetyl Tetrapeptide-22 (lebitso la lebitso Thermostressine®) ke peptide ea maiketsetso ea bioactive e entsoeng ka mesaletsa e mene ea amino acid, ka phetoho ea acetylated N-terminal. Phetoho ena e ikhethileng hangata e etselitsoe ho ntlafatsa botsitso ba peptide le ho kenella ha letlalo ho latelang. E sebetsa joalo ka peptide e bonts'ang, e etselitsoe ho etsisa lipontšo tse itseng tsa tlhaho tsa limolek'hule tseo 'mele oa motho o li sebelisang; ho laola tšebetso ea lisele tsa letlalo e le sepheo sa mantlha. E behiloe haholo-holo e le mosireletsi oa letlalo 'me maemong a mang e le moemeli oa ho lokisa, ho kenyelletsoa ho atileng lihlahisoa tse fapaneng tsa litlolo le tsa tlhokomelo ea motho ke phello e tobileng ea ts'ebetso ena.
Tatelano
Ac-His-Leo-Leo-Arg
Nomoro ea CAS
1295648-76-8
Foromo ea limolek'hule
C26H45N9O6
Boima ba Molek'hule
579.69 g/mol
Patlisiso ea Acetyl Tetrapeptide-22
Acetyl Tetrapeptide-22 e oela tlas'a lelapa la biomimetic peptide – sebopeho sa acetylated e le sepheo sa lipatlisiso tse ngata tsa morao-rao. Ho ntlafatsa ts'ebetso ea thibelo ea letlalo le mefuta eohle e amanang le ho tiea ha tikoloho ke mabaka a bohlokoa a ho hlophisoa ha eona e le motsoako o sebetsang., ‘tokiso ea letlalo’ ho ba e 'ngoe ea lisebelisoa tse fumanehang hangata. Li-peptide tse tšoanang tsa acetylated (Acetyl Tetrapeptide-2, Acetyl Tetrapeptide-3 haeba memori e ntshebeletsa ka nepo) arolelana morero ona oa sebopeho; botsitso le permeability ho ba lintlha tsa ho qetela tse fihletsoeng ka mokhoa oa acetylation.
Mosebetsi oa mantlha oa bioloji oa Acetyl Tetrapeptide-22 ke ho matlafatsa ts'ireletso ea kahare ea lisele tsa letlalo.. Ho laola Liprotheine tsa Heat Shock (HSPs) ke sepheo se haufi sa kamehla sa mochine oa eona.
Patlisiso mabapi le mochini o nepahetseng e lebisitse kutloisisong ea hajoale ea hore Acetyl Tetrapeptide-22 e sebetsa joalo ka molek'hule e bontšang matšoao.. Keratinocyte (le ho isa ntlheng ea lisele tsohle tsa letlalo) ho laola ho qaptjoa ha HSP70 karabelo ea peptide. HSP70 ka boeona e boloka protheine homeostasis; ho lemoha liprotheine tse senyehileng, ho sebedisa matla a yona ATPase ho li khutlisetsa morao kapa ho li romela hore li senyehe. Thibelo ea ho bokellana le lefu le felletseng la lisele ho tsoa khatellong e matla ke phello ea sena sohle.
Lisele tsa letlalo (le lisele tsohle ka tekanyo e itseng) e tla lula e le boemong bo sa feleng, boemo bo tlase ‘tšireletso’ naha. Acetyl Tetrapeptide-22, le li-peptide tsohle tse tšoanang, di teng mme di tla dula di le teng, se sireletsang boemong bo itseng ba kgatello ya maikutlo.
Ho sebelisa mesebetsi ea eona e ikhethang ea baeloji, acetyl tetrapeptide-22 e sebetsa e le motsoako o sebetsang oa theknoloji e phahameng ka har'a litlolo tsa litlolo.. E kenyelelitsoe ka bongata lihlahisoa tse thibelang khatello ea maikutlo le lihlahisoa tse thobang maikutlo, e sireletsa letlalo ho batho ba hlaselang letsatsi le letsatsi ba fapaneng ba tikoloho – kgahlamelo ya letsatsi, tshilafatso, boemo ba leholimo bo feteletseng ho ba mehlala e meholo.
Ho lokisoa ha letlalo la kutlo, poso-molumo eo, le tlhokomelo ea kamehla ea botsitso li loketse tšebeliso ea eona. Ka nako e ts'oanang mofuta o thibelang botsofali oa sehlahisoa o tla kenyelletsa motsoako ona. Ho sireletsa lisele ho tloha ho apoptosis pele ho nako le ho fokotseha ha tšebetso e latelang, ho boloka bocha ba 'mele le bo haufi le bo loketseng ba letlalo ke sepheo sa ho qetela; tikoloho le ho isa bohōleng bo itseng khatello ea kelello ea 'mele ke seo botsofali bo se emelang.
Libaka tsa tlhokomelo e khethehileng (‘pholoso’ lihlahisoa haeba u rata, batsamai kgafetsa, masiu a bosiu, mananeo a sa tsitsang kaofela a loketse mona) bona ho hlaphoheloa ka potlako ha bonyane maemo a letlalo a fokolang ka nakoana e le phello e ntle.
Acetyl Tetrapeptide-22 ke peptide e tšepisang ea litlolo; tokiso ea letlalo le ts'ireletso eohle e amanang le khatello ea maikutlo e le boleng ba eona ba mantlha. Lingoliloeng tse hatisitsoeng hajoale li fana ka phatlalatso e fokolang haholo ea mochini ofe kapa ofe kapa data ea bongaka ho tšehetsa liqoso tsena. Litlhaloso tsa lihlahisoa tsa brand li sutumelletsa meeli ea seo re se tsebang, le li-peptide tse tšoanang li bile teng (le ho tsoela pele ho ba) ithutiloe.
Ho netefatsa palo e felletseng ea katleho ea baeloji le ea bongaka ea sena kapa peptide efe kapa efe, ke bokamoso ba sebele ba saense ea litlolo.
COA
HPLC
MOF
