AHK ke tripeptide e entsoeng ka li-amino acid tse tharo: alanine (Ala), histidine (Hae) le lysine (Lys).
Peptide ena e nyane e na le molemo haholo transdermal ho monyela.
Ho lumeloa hore ka lebaka la li-amino acid tse nang le lihlopha tse fanang ka elektronike, joalo ka histidine le lysine tse hlahang sebopehong sa eona, e ka tlosa li-radicals tsa mahala le ho sireletsa lipids ho eona peroxidation le ho sebetsa antioxidant mesebetsi.
Ka bobeli metsoako ea lik'hemik'hale le ho behwa ka thoko ho tloha ho proteolysate ea liprotheine tsa tlhaho (mohlala, likhofu tsa metsing, liprotheine tsa lebese) hona joale ho khoneha ho hlahisa AHK.
Ho fapana le bongata ba macromolecular li-antioxidants, AHK e na le boima bo tlase ba limolek'hule ebile bo betere biocompatibility, se ka ba se loketseng haholo joalo ka setlolo se mafolofolo.
Tatelano
Ala-His-Ls
Nomoro ea CAS
126828-32-8
Foromo ea limolek'hule
Setšoantšo sa C15H26N6O4
Boima ba Molek'hule
354.40
Lipatlisiso tse amanang le AHK
Ba ne ba thahasella haholo ts'ebetso ea antioxidant mme ba etsa tlhahiso ea hore: Phello e kholo ea AHK e bakoa ke mesebetsi ea eona ea antioxidative, tse hlahisoang ke tatellano ea liketso tse latelang:
1.Ho qhekella ROS
ROS ke e 'ngoe ea lisosa tse kholo tsa ho baka oxidation ea cellular le botsofali letlalong..
Phetiso e tobileng ea dieleketerone kapa liathomo tsa haedrojene ho lokolla li-radicals ka botsona bakeng sa ts'ebetso ea ROS ke li-peptide tse ngata tsa antioxidant, e baka ho felisoa ha ROS.
The histidine le lysine masala a AHK a ka fana ka liathomo tsa haedrojene kapa lielektrone ho tima li-radicals tsa ROS. (DPPH, ABTS) ka kotloloho ho felisa oxidative karabelo ya ketane.
Ho tlalehiloe hore li-peptide tse nang le histidine li ka senya li-radicals ka HLOKOMELA (Phetisetso e le 'ngoe ea Elektrone) kapa SEHLOBA (Phetisetso ea Athomo ea Haedrojene) tshebetso.
2.Ts'ebetso ea Endogenous Antioxidant Systems
Li-peptide tse ling tsa antioxidant li boetse li eketsa bokhoni ba lisele tsa anti-oxidative ka ho susumetsa li-anti-oxidase tsa bohlokoa tsa intracellular. (mohlala, superoxide dismutase SOD, glutathione peroxidase GSH-Px)².
Mehlala e meng ea lisele, Li-peptide tsa mofuta oa AHK li ka ntlafatsa polelo ea li-enzyme tsa tlhaho tsa antioxidant joalo ka SOD le GSH-Px., e leng eona e ka thusang ts'ireletso ea cellular khahlano le khatello ea oxidative.
3.Ion ea tšepe Chelation
The imidazole lesale la histidine le amino sehlopha sa lysine ka rarahaneng le li-ion tsa tšepe tsa phetoho (joalo ka Fe²⁺, Cu²⁺), e tla fokotsa tshepe-catalyzed Fenton reactivity, ka tsela eo ho lebisa ho thibelo ho hydroxyl radical sebopeho ⁴.
Motsoako oa eona oa koporo oa ion (AHK-Cu, e tsebahalang joalo ka GHK-Cu kapa koporo tripeptide-1) –sebakeng sa AHK feela– e na le ts'ebeliso e tsebahalang le e tsebahalang ho litlolo.
Melemo e nkiloeng ho antioxidant, collagen regeneration induction le ho lokisoa ka potlako, AHK e sebelisitsoe mefuteng e fapaneng ea lihlahisoa tsa letlalo.
4.Bakeng sa lihlahisoa leha e le life tse thibelang botsofali tsa serum le tranelate
Ho tiisa letlalo le hlephileng le ho fokotsa wrinkles ka ho khothaletsa syntonyization ea collagen & ho loants'a khatello ea mali.
5.Bakeng sa litlolo tsa ka mor'a ho buuoa kapa ho lokisa maqeba
Ho khothaletsa mekhoa ea tokiso ea epidermial ha e ntse e khutsufatsa nako e amehang ea ho folisa.
Litlolo tsa tlhokomelo ea letlalo la hlooho le moriri: Lithuto li ile tsa paka bokhoni ba eona ba ho phahamisa angiogenesis pota-potileng follicle ea moriri ho fihlella kgolo ya moriri& ho etsa hore e be monyetla oa li-shampoo tse thibelang tahlehelo kapa li-serum tsa kholo.
Ho feta moo, ka li-antioxidant formulations, AHK e na le monyetla oa ho eketsa melemo ho metsoako e kang Vitamin C le E, ho ntlafatsa ts'ebetso e pharalletseng e ikhethang ea anti-oxidant network ea skincare e ka ntlafatsang ts'ireletso *1 le ho lokisa mesebetsi letlalong..
COA
HPLC
MOF
