Oligopeptide-2 ke peptide ea bioactive e nang le thahasello e kholo lefapheng la litlolo., haholo-holo e sebelisoang lihlahisoa tse khahlanong le wrinkles le anti-botsofali.
E ipapisitse le sekhechana ho tloha sebakeng sa C-terminal sa ketane ea collagen α1., e kenya letsoho ho kopanya collagen-laminin-integrin.
Sekhechana sa peptide ea tlhaho, leha ho le joalo, e potlakiloe ke liprotheine letlalong la letlalo, ho sitisa ho kenella ha eona ka katleho ka ho stratum corneum.
Sena se hlahisitse palo ea tse nkiloeng, e atlehileng ka ho fetisisa e leng Oligopeptide-2.
Palmitoyl moiety e eketsoa ho eketsa lefu la tsoekere ea peptide, ho nolofatsa ho kenella ha eona ka epidermal lihlahisoa tsa lipid 'me kahoo ho eketsa botsitso ba kakaretso bakeng sa ho kenyelletsoa ha litlolo tsa litlolo.
Ka lebaka leo, Oligopeptide-2 e fetohile karolo ea bohlokoa ho litlolo tsa boleng bo holimo.
Tatelano
H-Lys-Thr-Thr-Lys-Ser-OH
Nomoro ea CAS
149128-48-3
Foromo ea limolek'hule
C23H45N7O9
Boima ba Molek'hule
563.65
Lipatlisiso tse amanang le oligopeptide-2
1.Mokhoa oa Ts'ebetso le Melemo
Oligopeptide-2 e susumetsa fibroblast kgolofatso, e kenya tšebetsong litsela tse tlase tsa mats'oao a intracellular, e eketsa ka mokhoa o makatsang hape synthesis li-collagen tsa mofuta oa I le oa III, hlasimolla ka bokgabane Fibronectin le glycosaminoglycan tlhahiso le ho bonts'a ts'ebetso ea chemotactic, ho khothaletsa phallo ea fibroblast le ho bokellana libakeng tse reriloeng, ka hona ho potlakisa ho hlaphoheloa ha letlalo.
Ka tšebeliso e tsoelang pele, Oligopeptide-2 e fokotsa botebo le letsoalo la makhopho a sefahleho, e ntlafatsa sebopeho sa letlalo mme e matlafatsa ts'ebetso ea thibelo ea letlalo.
2.E khothalletsa Collagen Synthesis
Oligopeptide-2 e tlama ho li-receptor tse khethehileng ho li-membrane tsa fibroblast, kenya tshebetsong tsela ea pontšo ea TGF-β.
Sena se lebisa ho ts'ebetsong ea collagen synthesis-associated mRNA, e khothalletsang tlhahiso e atlehang haholo le e potlakileng ea intracellular ea selelepele limolek'hule tsa mofuta oa I le oa III oa collagen.
Tsena li ntse li sebetsoa hape hore e be marang-rang a felletseng le a tsitsitseng a likhoele tsa collagen.
Sena se eketsa collagen fiber density le boleng, ho etsa hore letlalo le be le elasticity le ho tiea le ho fokotsa masoba.
3.E Khothalletsa Tlhahiso ea Fibronectin le Glycosaminoglycans, Ho matlafatsa Matla a Letlalo
Ho phaella ho collagen synthesis, Oligopeptide-2 e susumetsa tlhahiso le ts'ebetso ea fibronectin le glycosaminoglycans..
E ntlafatsa ts'ebetso ea fibronectin le hyaluronic acid synthase, ho fella ka gel matrix e ntlafatsang matla a ho boloka mongobo oa letlalo.
Ka lebaka leo, letlalo le bonahala le le lerootho, e tletse ebile e na le metsi ho feta.
4.Phello ea Chemotactic
Oligopeptide-2 e na le thepa e matla ea chemotactic, e tataisang li-fibroblasts le lisele tsa tsona tse tlang pele hore li fallele ka tsela e eang libakeng tse senyehileng tsa letlalo.
Sena se ntlafatsa haholo le ho potlakisa tokiso ea letlalo, ho netefatsa ho tsosolosoa ha boleng bo phahameng ba lisele tse senyehileng.
COA
HPLC
MOF
