Myristoyl Pentapeptide-8 ke bioactive cosmetic peptide e entsoeng ka phetoho ea lik'hemik'hale ea tlhaho. tatellano ya pontsho.
Khōlo ea eona e ikhethang ea moriri le mesebetsi e fapaneng ea litlolo e amahanngoa le sekhechana se itseng se bolokiloeng sa pentapeptide., Lys-Thr-Thr-Lys-Ser, e nkiloeng ho ketane ea α1 ea mofuta oa I procollagen.
Ketso ea eona e hlalosang ke ho susumetsa dermal li-fibroblasts , ka ho etsa joalo ho qalella cascade e latelang e khothalletsang motsoako oa bobeli collagen le Fibronectin.
Leha ho le joalo, ho senyeha ho potlakileng ha enzymatic ho hlahisa tšitiso e kholo ts'ebelisong ea eona ea kalafo e sebetsang.
Ho hlola sena, bafuputsi ba fetotse peptide ka conjugating eona le a asiti e mafura ketane. Phetoho ena e boloka litšoaneleho tsa pele tsa tefiso ha e ntse e ntlafatsa haholo tšebelisano le li-intercellular lipids tsa stratum corneum.
Ka lebaka leo, phetoho e eketsa peptide halofo ea bophelo mme e ntlafatsa haholo ea eona transdermal ho phunyeletsa bokgabane.
Ka kakaretso, peptide ena e fihlela katleho e matla ea litlolo, ho boloka sebaka sa eona ho premium skincare formulations.
Tatelano
Lys-Thr-Thr-Lys-Ser (KTTKS)
Nomoro ea CAS
2305730-23-6
Foromo ea limolek'hule
C37H71N7O10
Boima ba Molek'hule
774.01
Lipatlisiso tse amanang le Myristoyl Pentapeptide-8
1.Motsoako oa Dermal-Epidermal Junction le Ntlafatso ea Sebopeho sa Letlalo
Bopaki ba liteko bo bontša hore Myristoyl Pentapeptide-8 e etsisa pontšo ea baeloji ea lamine-5, ka tsela eo ho matlafatsa le ho lokisa sebopeho le mosebetsi oa dermal-epidermal junction (METSI).
E susumetsa dermal fibroblasts ho kopanya le ho kopanya senotlolo lera le ka tlaase dikarolo, ho kenyelletsa le collagen I, III, le elastin.
Sephetho sa ho qetela ke ho matlafatsa mohaho oa ka hare oa letlalo, e fokotsang botebo le palo ya makukuno (ka tahlehelo ea elasticity e leng eona ntho e ka sehloohong e tlatsetsang), ho lebisa letlalong le tiileng le le shebahalang le phetse hantle.
E boetse e na le tšusumetso e ntle keratinocyte phapang le keratin polymerization.
2.Khothatso e otlolohileng ea ho Tsosolosoa ha Dermal Collagen
Joalokaha ho boletsoe, peptide e tlama le ho kenya tšebetsong protheine e amanang le li-receptor tsa LDL (Liprotheine tse amanang le li-receptor tsa LRP/LDL) sebakeng sa fibroblast, ho tsosa ditlamorao tse boletsweng ka hodimo.
3.Taolo ea Moriri oa Khōlo ea Follicle ea Moriri
Myristoyl Pentapeptide-8 e kenya tšebetsong tsela ea β-catenin/LEF1 ka hare. papilla ea letlalo lisele.
Ketso ena e thibela BMP4-matshwao a ho kgutlela morao, ka tsela eo ho lelefatsa anagen ka kotloloho (kgolo) mokhahlelo oa lesapo la moriri.
Bopaki ba liteko ho tsoa ho mohlala oa toeba ea androgenetiki alopecia e tšehetsa mochine ona; kopo e tsoelang pele bakeng sa 21 matsatsi a lebisitse ho keketseho e lumellanang ea lintši, mahlo a mahlo, le ho teteana ha moriri oa hlooho.
4.Ntlafatso ea Ts'ebetso ea Sethibelo sa Letlalo le Ts'ebetso ea Antioxidant
Sebopeho se ikhethileng sa Myristoyl Pentapeptide-8 se fana ka botsitso bo ntlafalitsoeng, ka myristoyl moiety ka boeona e baka tšitiso ea steric.
E theola moeli oa ts'ebetso bakeng sa lintlha tsa ho ruruha, ka tsela eo ho ntlafatsa matla a letlalo ho mamella khatello ea tikoloho.
E tšehetsa phapang e tloaelehileng ea lisele tsa epidermal le potoloho ea eona ea metabolism.
Ho feta moo, e khothalletsa tlhahiso ea lipids tsa bohlokoa (ho kenyeletsa li-ceramide) ka har'a stratum corneum, qetellong ho matlafatsa mokoallo oa 'mele le ho theha tikoloho e nepahetseng ea letlalo.
Sephetho sa nako e telele ke botsitso bo ntlafetseng ba letlalo.
COA
HPLC
MOF
