Biotinoyl Tripeptide-1 (lebitso le leng: Organic GHK / Biotin-GHK / Biotinyl-Gly-His-Ls / Biotinyl-GHK) ke bioactive peptide e entsoeng ka covalently hokela biotin (vithamine H) ho GHK – glycine-L-histidine-L-lysine tripeptide. Kopano ena e boloka tatellano ea mantlha ea GHK; ka khopolo e e lumella ho boloka bonyane mofuta o itseng oa mesebetsi ea eona ea mantlha ea baeloji, ha e ntse e hlahisa matla a ho tlama a khethehileng ao biotin e khonang ho a etsa.
Tatelano
Biotin-Gly-His-Lys-OH
Nomoro ea CAS
299157-54-3
Foromo ea limolek'hule
C24H38N8O6S
Boima ba Molek'hule
566.7 g/mol
Patlisiso ea Biotinoyl Tripeptide-1
Motheo oa sebopeho sa Biotinoyl Tripeptide-1 ka boeona ke tripeptide GHK ena. Patlisiso e batsi e entsoe mesebetsing e fapaneng e pharalletseng ea baeloji ea GHK – tokiso ya dithishu, anti-inflammation ke mehlala e 'meli e meholo, ka ho thibela botsofali e le karolo e ithutoang haufinyane.
Biotin e le coenzyme ea bohlokoa e thusa ho kopanya keratin (protheine ea mantlha e fumanoang moriring); ho boloka bophelo bo botle ba moriri ke e 'ngoe ea likarolo tsa eona tse haufi le kamehla. Ho e hokahanya le peptide ho fana ka ts'ehetso e ka bang teng ea phepo e nepahetseng, empa ntlha ea bohlokoa haholo ke kamano e haufi ea biotin bakeng sa lisele tsa follicle tsa moriri; ho ntlafatsa katleho e tlamang libakeng tsena tse shebiloeng, bioavailability le katleho e itseng [1].
Lipatlisiso li bontša ho bolokoa ka katleho ha koporo ea GHK, mesebetsi e fapaneng ea antioxidant le anti-glycation; phepelo e lebisitsoeng e le eona ntlafatso ea mantlha ea ntlafatso ea biotin e lumellang. Thibelo e kholo ea acrolein (ACR)-e susumelitse Aβ carbonylation (lesupa la tšenyo ea oxidative) le ho fokotseha ha sebopeho sa li-adducts tse boletsoeng.
Ascorbic acid oxidation e hlahisoang ke Cu(II)-Aβ complex e boetse e thibetsoe, ho fokotsa tsohle tse latelang mefuta ea oksijene e sebetsang (ROS) moloko (hape, katleho e fokolang ha e bapisoa le GHK e hloekileng e bonoa, ba tshoeroeng C-terminal ho ba lebaka le ka etsahalang).
Tlhahlobo ea Spectrophotometric (2-(4′-Hydroxyazobenzene) Benzoic Acid/HABA phalliso) e netefalitse tlamahano e phahameng ea streptavidin ke Biotinoyl Tripeptide-1 – tebelo e hloekileng ea boemo ba biotin e bolokiloe.
Biotinoyl Tripeptide-1 ke 'me e ntse e le peptide e ikhethang ea biotinylated, ka kapa ntle le ditlolo tsa setlolo, ho sepheo le merero eohle molek'hule e ncha e khahlang haholo mahlale le mosebelisi oa ho qetela.
Biotinoyl Tripeptide-1 hangata e kopantsoe le lisebelisoa tse ling tse fapaneng tse thibelang ho lahleheloa ke moriri; minoxidil, finasteride, mefuta e fapaneng ea lihlahisoa tsa limela (bona Palmetto e le mohlala o ka sehloohong, salvia miltiorrhiza le ginkgo biloba le tsona li ithutoa hantle), livithamine (biotin haeba ke hopola ka nepo e le eona e atileng haholo, livithamini tsa B tse ngata), le ho latela lintlha tse kang zinki le selenium.
Motsoako o latela mokhoa oa phekolo o nang le lipheo tse ngata – ho sebetsana le seo ke lumelang hore se ngata, mekhoa ea nako e le 'ngoe ea pathophysiological ea ho lahleheloa ke moriri.
Biotinoyl Tripeptide-1 ka boeona ke peptide e sebetsang ka bongata, phello ea mofuta o itseng oa boenjiniere ba limolek'hule. GHK e nchafatsoa ka tlhaho, Antioxidant le ho isa bohōleng bo itseng thepa ea neuroprotective e kopantsoe ka boqhetseke le bokhoni bo khethehileng ba ho fana ka biotin.
Khoebo tšimong ea litlolo e iketsetse e le e khahlanong le botsofali le (haufinyane tjena) ho hola ha moriri. Thibelo e boletsoeng pejana ea amyloid aggregation e sutumelletsa lipatlisiso pele; mafu a neurodegenerative, Alzheimer's ka ho khetheha, li ts'episa likopo tsa nako e tlang.
Patlisiso e tebileng le e felletseng e tla hlalosa feela sebaka sa Biotinoyl Tripeptide-1 maemong ohle a bophelo bo botle ba batho le mafu..
COA
HPLC
MOF
