Cartalax ke peptide ea maiketsetso e khutšoane e nang le tatellano ea amino acid Ala-Glu-Asp.. E tsoa ho sekhechana sa protheine ea tlhaho se teng ka har'a lefufuru le phetseng hantle, ke molek'hule oa maiketsetso o entsoeng ka hloko.
Tatelano e khethehileng ea li-amino acid e etsisa tsa endogenous lipontšo tsa limolek'hule; ho tlama ho li-receptor tse itseng tsa cellular, Karabelo e latelang ea likarabelo tsa cellular e qala.
Moralo o hlakileng oa maiketsetso o fana ka ts'ebetso e phahameng ea tlhaho ea Cartalax, tse khethehileng, immunogenicity e tlase, le ho monya hantle ho fetisang letlalo kapa ka molomo.
Patlisiso e ntseng e tsoela pele e fana ka lintlha tse ngata tseo e li reretsoeng, matla a mangata a ho sireletsa le ho lokisa.
Khatello e sebetsang ea ho ruruha ke e 'ngoe ea liphello tse joalo – theolelo ea pro-inflammatory cytokine hlohlelletse Matrix metalloproteinases (MMPs) le ADAMTS'O ho ba mekhoa ea mantlha; khoholeho e tobileng le ho senyeha ha mofuta oa II collagen le tse fapa-fapaneng li-proteoglycans li fokotsehile, lefufuru la articular botshepehi ba sebopeho se baballetsoeng.
Ho matlafatsa matla a ho tsosolosa ea matrix a extracellular ke mokhoa o mong oa ts'ebetso o hlahisitsoeng ke liphuputso tsa morao-rao; chondrocyte matshwao a itseng a laolwa mme ho kgothaletswa ho kopanya ha ona.
Tšenyo e nyane ea lefufuru e ka lokisoa ka mekhoa ena, bophelo bo botle homeostasis hlokometsoe.
Anti-inflammatory, thepa ea immunomodulatory le e thibelang botsofali kaofela ke karolo ea boemo ba Cartalax; liteko tsa tleliniki ha joale li ntse li hlahloba tsohle tse ka holimo.
Synthesis le tšebeliso ea Cartalax e emela tataiso e tšepisang ea bioactive peptide therapy.
Tatelano
Ala-Glu-Asp
Nomoro ea CAS
/
Foromo ea limolek'hule
C12H19N3O8
Boima ba Molek'hule
333.297
Patlisiso ea Cartalax Peptide
1.Thibelo ea Lefufuru Catabolism
Joalokaha ho boletsoe, thibelo ea ho senyeha ho feteletseng ke motheo oa lipatlisiso tsohle tse thehiloeng Cartalax.
E sa tloaelehang pro-inflammatory factor sesupo se tlameha ho sitisoa, le li-enzyme tse ikarabellang bakeng sa ho theola matrix (hape, haholo-holo Li-MMPs / Matrix Metalloproteinases) e thibetsoe ka kotloloho kapa ka tsela e sa tobang.
Botšepehi ba mechine ea lisele tsa lefufuru ke qetello ea mosebetsi ona kaofela.
2.Ho phahamisa Lefufuru Synthesis
Cartalax e boetse e bonts'a bokhoni bo ikhethang ba ho ntlafatsa metabolism ea anabolic.
Ho phahamisa chondrocyte mosebetsi o sebetsang, e eketsa ka potlako motsoako le secretion e latelang ea likarolo tse sa tšoaneng tsa extracellular matrix; ho thehoa ha lefufuru ka ho toba ke phello ea mantlha ea ts'ebetso ena.
Lithuto tsa in vitro li netefalitse phello ena – li-chondrocyte tse tšoaroang kapa lisele tsa stem li bontša liphatsa tsa lefutso tse phahameng haholo tsa mofuta oa II collagen le aggrecan, ka keketseho e lumellanang ea tlhahiso ea 'nete ea liprotheine tse boletsoeng.
Ntlafatso e 'ngoe e sa tobang ea metabolism ea cellular le synthesis ea protheine e fihlelleha ka litsela tse khethehileng tsa matšoao a intracellular. (TGF-β/Smad ke mohlala o motle); ho tsosolosoa ha lisele ke phello e lakatsehang.
Ho lokisa microdamage e neng e le teng pele le ho aha matrix e sebetsang ke litsela tse peli tsa bohlokoa tse nolofalitsoeng ke mohato ona oa ts'ebetso..
3.Anti-inflammatory le Immunomodulatory Effects
NF-kB e sebetsa e le letšoao la bohlokoa bakeng sa ho kenya tšebetsong lintlha tse ngata tsa ho ruruha.
Cartalax e hatella ka mafolofolo, kapa bonyane e fokotsa, Polelo ea NF-κB – ho otla mohloli oa likarabo tse ngata tsa ho ruruha.
Bohloko, ho ruruha le ho satalla ho sa feleng ho amanang le ho ruruha kaofela li fokotsehile ka katleho.
Liphello tsa tšireletso ea lefufuru tse hlalositsoeng ka holimo ke karolo ea tlhaho ea ts'ebetso ena e khahlanong le ho ruruha; ho fokotsa ho ruruha ke karolo ea motheo ea mokhoa o akaretsang oa ts'ebetso ea Cartalax.
COA
HPLC
MOF
