Dipeptide-2 ke dipeptide ea bioactive eo qalong e ithutoang haholo bakeng sa litlamorao tsa eona tse thibelang botsofali indastering ea litlolo.. Lebitso le leng 'Eyeliss’ ka ho khetheha e bua ka ts'ebeliso ea eona e lebisitsoeng ho feta; ho ntlafatsa mathata a fapaneng a letlalo sebakeng sa mahlo – mekotla e ka tlas'a mahlo e le mohlala o ka sehloohong, didikadikwe tse lefifi ho ba enngwe.
Tatelano
Val-Trp
Nomoro ea CAS
24587-37-9
Foromo ea limolek'hule
C16H21N3O3
Boima ba Molek'hule
303.36 g/mol
Lipatlisiso tsa Dipeptide-2
Ka hare ho cosmetic science, Dipeptide-2 e khetholloa e le peptide ea bioactive e nang le matla a ho thibela botsofali. Tlhokomelo ea letlalo e khahlanong le botsofali e sutumelitse li-peptide tsa bioactive ho ea pele ho nts'etsopele ea sejoale-joale; boima ba molek'hule e nyane, e matla (ho isa bohōleng bo itseng) bokgoni ba ho tsepamisa, le ho kenella ha letlalo hantle ha letlalo kaofela li tlatsetsa botumong ba tsona. Bioactivity ea mantlha ea dipeptide-2 ka boeona e tsoa ho enzyme e fetolang angiotensin (ACE) ho thibela thepa. Sena se theha motheo o haufi oa theory bakeng sa katleho efe kapa efe ea litlolo eo e ka e bonts'ang, circulation related letlalo dingongoreho e le e 'ngoe ea likopo tse tobileng ho feta.
Angiotensin-E fetolelang Enzyme (ACE) ke metallopeptidase ea bohlokoa ea zinki; ho susumetsa phetoho ea Angiotensin I ho vasoconstrictor e matla Angiotensin II (Sisteme ea renin-angiotensin e ikarabella bakeng sa ts'ebetso ena). Angiotensin II joalo ka ha ho boletsoe, e baka vasoconstriction, khatello e phahameng ea mali, ho boloka mokelikeli o ka bang teng.
A 2015 ho ithuta ho arola dipeptide-2 ka katleho ho tsoa tlhapi ea leoatle le tebileng protheine hydrolyzate, e netefatsa bokhoni ba eona ba ho thibela ACE – Litekanyetso tsa IC50 li tlalehiloe, tlase ho lekana ho bonts'a ts'ebetso e matla ea in vitro. Ho na le bopaki bo hlakileng ba in vitro ba hore ho na le thibelo ena e khethehileng ea ACE.
E netefatsa ts'ebetso e amanang le ACE e kaholimo, thuto e tšoanang e boetse e supa thepa ea eona ea antioxidant. Khatello ea oxidative ke mofuta o ka sehloohong oa botsofali ba letlalo; Mefuta e mengata ea oksijene e sebetsang ka ho feteletseng e senya likarolo tsohle tsa lisele (DNA, liprotheine, lipids) le ho kenya tšebetsong li-enzyme tse senyang tsa matrix a extracellular. Val-Trp, bonyane ka karolo e itseng, e sireletsa sele ea letlalo ho senya mofuta ona – Litlamorao tsa mofuta oa mahala tse thibelang botsofali ke mokhoa oa bohlokoa oa tlatsetso ho tse ling ('me e ngotsoe hantle) melemo.
Ka ho thibela ts'ebetso ea ACE ka tlholisano, Dipepetide-2 e fokotsa tlhahiso ea angiotensin II. Vasoconstriction le edema ea sebaka se latelang e fokotsoa ka ho toba ke phokotso ena.
Mochine ona o bohlokoa haholo ho skincare; Thibelo ea ACE ka ho khetheha e fokotsa ho kenella ha capillary, ho thibela mefuta e itseng ya ho bokellana ha lero. Ho ntlafala ha lymphatic drainage ke phello ea bohlokoa ea ts'ebetso ena, ka ho ruruha ha periorbital le mefuta e fapaneng ea hyperpigmentation e fokotsehileng haholo. Microcirculation e ntlafalitsoeng ka boeona e tlisa oksijene e betere le phepelo e akaretsang ea limatlafatsi liseleng tsa letlalo – bophelo bo botle ba cellular le matla a haufi a kamehla e le liphello tsa ho qetela.
Ho bolela hore dipeptide-2 (boemong ba tlhokomelo ya mahlo) e ka ‘felisa mekotla ea mahlo, didikadikwe tse lefifi, le edema e amanang le eona’ ke tšebeliso e nang le motheo o motle oa mokhoa ona oa ho beha mabaka.
Dipeptide-2 ke motsoako o atileng haholo ka har'a premium anti-aging skincare, litlolo tsa mahlo ke mohlala o ka sehloohong. Periorbital edema le bonyane likarolo tse ling tsa li-circles tse lefifi li fokotsoa ke eona. Ho matlafatsa mokoallo oa letlalo le hydration eohle e pota-potileng ke tlatsetso, melemo e tlalehiloeng hantle.
Lithuto tsa tleliniki li tšehetsa lintlafatso tsohle tse boletsoeng ka holimo; ho tiea le ho khanya ke lintlha tsa ho qetela tsa katleho ea kalafo.
COA
HPLC
MOF
