Peptide ea Delta e bakang boroko (DSIP) e sebetsa ka baeloji neuropeptide e entsoe ka li-amino acid tse robong. Ho sibolloa ha DSIP ho emetse phetoho kutloisisong ea taolo ea boroko-ho tloha paradigm e fetileng ea li-nuclei tse bohareng tse laolang boroko ho isa tlhokomelong ea karolo e phethoang ke balaoli ba boroko ba endogenous..
Peptide ena e bonts'a mesebetsi e pharaletseng ea 'mele le mokhoa o ikhethileng oa ts'ebetso. Bokhoni ba eona ba ho tšela ka potlako mokoallo oa mali-boko(BBB) ke e 'ngoe ea litšobotsi tsa eona tse hlokomelehang; ho kenya letsoho ha eona taolong ea hypothalamic-pituitary-adrenal (HPA) axis le tšusumetso ho systemic homeostasis kaofela li ngotsoe hantle.
Ho feta mesebetsi ea eona ea mantlha ea taolo ea boroko (ho phahamisa boroko bo tebileng, kaho e ntlafetseng ya ho robala, le boleng bo ntlafetseng ba boroko), DSIP e bonts'a matla a methapo ea kutlo le, ho isa tekanyong e khōlō, bokgoni ba ho lokisa. Ho ntlafatsa ho hanyetsa ha methapo ea kutlo ho mefuta e sa tšoaneng ea overstimulation ke mohlala o ka sehloohong oa sena.
Taolo ea endocrine le thermoregulation hape ke mesebetsi e thehiloeng ea DSIP. Haufinyane tjena, antioxidant le detoxification mesebetsi e bonoe.
Tatelano
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Nomoro ea CAS
62568-57-4
Foromo ea limolek'hule
C35H48N10O15
Boima ba Molek'hule
848.33
Lipatlisiso Tsa Delta Sleep Inducing peptide (DSIP)
1.Liphello Tse Hlollang Boroko
Taolo ea boroko ke eona ntho e ka sehloohong e amanang le DSIP. Kholiso e matla le e khethang ea ho robala butle ke phello ea eona e tlalehiloeng khafetsa. Lisebelisoa tsa khale tsa khale tsa ho robala li sebetsa ka mekhoa e fapaneng ka ho felletseng; DSIP, joalo ka endogenous neuroregulatory peptide, physiologically modulates (ka tsela e mamelloang hantle) moaho wa boroko ba mosebedisi. Ho eketsa nako ea boroko bo tebileng ke kamano e tobileng ea boleng bo ntlafetseng ba boroko.
Thuto e kenyeletsang 400 bakuli ba nang le bothata bo boholo lefu la ho hlobaela, ba fumaneng liente tsa DSIP tse sa khaotseng bakeng sa beke, e bontšitse ntlafatso e kholo likarolong tsohle tse lekantsoeng tsa boleng ba boroko. Bakuli ba nang le neurotic irritability, ka ho khetheha, e bontšitse keketseho e hlakileng ea ho ikamahanya le maemo a ka ntle ka mor'a ente.
Liphetho tsena li totobatsa karolo e matla ea DSIP taolong ea boroko le bokhoni ba eona ho alafong mathata a methapo..
2.Thempereichara ea 'Mele le Molao oa Mosebetsi oa Motlakase
Lithethefatsi tse ling tse ntlafatsang tšebetso ea boko ba dopamine li ka fetola mocheso oa 'mele. DSIP e sebelisana le lithethefatsi tsena, ho susumetsa liphetoho tse boletsoeng ka holimo.
Boithuto ho litoeba bo bonts'itse hore litekanyetso tse nyane ho isa ho tse itekanetseng tsa DSIP li fokolitse ts'ebetso ea koloi le mocheso oa 'mele tlasa maemo a 4 ° C..
Ha litoeba li khutlisetsoa tikolohong ea 22°C, Tsamaiso ea DSIP e ne e amahanngoa le ho eketseha ha mocheso oa 'mele.
3.Mosebetsi oa Endocrine Regulatory
HPA axis ke eona ea mantlha tsamaiso ea methapo ea kutlo bakeng sa karabelo ea 'mele ea khatello ea maikutlo.
Overactivation ea tsamaiso ena e lebisa ho sa tloaelehang, maemo a phahameng a cortisol a sa foleng. DSIP e thibela phello ena ka ho thibela tokollo ea CRH le ACTH.
4.Mesebetsi ea Neuroprotective le Reparative
DSIP e bonts'itse thepa ea methapo ea kutlo le ea ho lokisa e emelang karolo ea bohlokoa ea matla a eona a kalafo.
E bontša tšepiso ea phekolo ea mafu a neurodegenerative , hara maemo a mang.
COA
HPLC
MOF
