Humanin ke peptide e kentsoeng ka mitochondrial e nang le 24 li-amino acid; qalong e ile ea sibolloa molemong oa lipatlisiso tsa lefu la Alzheimer's.
Ho bakuli ba Alzheimer, ho hlahisa Humanin ka har'a lisele kapa ho e eketsa e le peptide ea endogenous e sireletsa li-neurone tsena mefuteng e fapaneng ea tšenyo e amanang le Alzheimer's. – litlamorao tsa bohlokoa tsa neuroprotective e le tlhokomeliso ea mantlha e entsoeng.
Humanin e kenya tšebetsong litsela tsa bohlokoa tsa ho pholoha ha lisele, the JAK2/STAT3/ACT ho ba mehlala e meholo, ka katleho ho thibela litsela tsa apoptotic tse itšetlehileng ka mitochondrial; Aβ, ischemia-hypoxia, le mefuta e mengata ea khatello ea oxidative e le lintho tse susumetsang tse boletsoeng.
Ho matlafatsa li-antioxidant tsa cellular le ho isa tekanyong e kholo matla a ho thibela ho ruruha ke phello e 'ngoe e tlalehiloeng hantle.
Tatelano
Kopana - Ala - Pro - Arg - Gly - Phe - Ho ba - Cys - Leu - Leu - Leu - Leu - Thr - Ho ba - Glu - Ka - Asp - Leu - Pro - Val - Lys - Arg - Arg - Ala
Nomoro ea CAS
330936-69-1
Foromo ea limolek'hule
Setšoantšo sa C119H204N34O32S2
Boima ba Molek'hule
2687.27
Lipatlisiso Tse Amanang le Batho
1.Melemo ea Phekolo le Likopo tsa Tleliniki
Mesebetsi ea bohlokoa molemong oa ho khothaletsa metabolism ea glucose, ho ntlafatsa bonyane mofuta o itseng oa kutloisiso ea insulin, le ho sireletsa methapo ea mali ho bontšitsoe kaofela.
Ka hona, peptide e sirelletsang joalo ka Humanin e na le monyetla o moholo oa ho alafa (kapa bonyane ho ntlafatsa) e amanang le dilemo mafu a fokolisang; Litlhare tse khahlanong le botsofali le tse tobileng haholoanyane tsa Alzheimer's hajoale li ntse li phehelloa ho ipapisitse le mokhoa ona oa lipatlisiso.
2.Mesebetsi ea Tšireletso ea Metabolic le Vascular
Ts'ebetso ea bohlokoa ho nts'etsopele ea metabolism ea glucose, ho ntlafatsa bonyane mofuta o itseng oa kutloisiso ea insulin, le ho sireletsa methapo ea mali ho bontšitsoe kaofela.
Ka hona, peptide e sirelletsang joalo ka Humanin e na le monyetla o moholo oa ho alafa (kapa bonyane ho ntlafatsa) mafu a amanang le lilemo; Litlhare tse khahlanong le botsofali le tse tobileng haholoanyane tsa Alzheimer's hajoale li ntse li phehelloa ho ipapisitse le mokhoa ona oa lipatlisiso.
3.Liphello tsa Neuroprotective
Khahlano e tobileng ea chefo ea β-amyloid ke eona e hlalosang mosebetsi oa Humanin oa neuroprotective. – ho bokellana le ho beha Aβ ka morao ke lintlha tsa bohlokoa ho qaleng ha lefu lena.
Receptor ka boeona e kenya tšebetsong litsela tseo ho buuoeng ka tsona pejana tsa intracellular.
Lipontšo tse tsoang ho Humanin li thibela litsela tse boletsoeng ka holimo tsa apoptosis, ho hatelloa ha liprotheine tsa ts'ebetso; lefu le hlophisitsoeng la neuronal bonyane le thibetsoe ka mokhoa o itseng.
Ka holim'a Aβ, mafu a fokolisang methapo ea kutlo (Lefu la Parkinson, Setšoantšo sa Huntington haholoholo) bontsha tshoanang, haeba e sa tshwane, melemo ea neuroprotective ho tsoa ho Humanin.
Tšireletso ea pelo e emela karolo ea bohlokoa ea bohlokoa ba phekolo ea Humanin.
Khatelo-pele ea Humanin e le moemeli oa phekolo e emela tsoelo-pele ea bohlokoa saenseng ea bongaka.
4.Antioxidant le Anti-Apoptotic Effects
Motheo oa Humanin, Mosebetsi oa mantlha ke ho thibela apoptosis ea lisele e tloaelehileng e bakoang ke khatello ea maikutlo e feteletseng.
Khatello e feteletseng ea oxidative mme kamora moo mofuta ona oa apoptosis ke tse ling tsa lisosa tsa mantlha tsa mafu a fapaneng le maemo ohle a amanang le lilemo..
Humanin e ntlafatsa ts'ebetso ea khatello ea antioxidant ka har'a lisele tsa lisele; ho hanyetsa ho lokolloa ha mitochondrial cytochrome C ho ba karolo ea bohlokoa ea ts'ebetso ena. Mokhoa ona o matla oa fisioloji o hatella ho qaleha ha litsela tsa ka hare tsa apoptosis, tšenyo ea oxidative ke eona ntho e ka sehloohong e amehang.
Ka ho khetheha, Liphello tsa ho tsitsisa lisele tsa Humanin li fetela ka nģ'ane ho lisele tse khethehileng tsa lisele – Ts'ireletso e felletseng ea likarolo tse ngata khahlano le khatello e feteletseng ea oxidative le mefuta eohle ea eona ea apoptosis, ke seo Humanin a fanang ka sona; ts'ebeliso e pharaletseng ea ts'ireletso ena e bonoa.
5.Physiological Regulation
Humanin e bapala karolo ea bohlokoa taolong ea systemic metabolic homeostasis, botsitso ba cellular ke e 'ngoe ea liphetho tse bonoang ka kotloloho. Glucose metabolism ke mohlala o ka sehloohong.
Liteko li bonts'itse maemo a tlase a lekantsoeng a mofuta oa humanin 2 bakuli ba lefu la tsoekere.
Ho eketsa humanin hoa ntlafala mamello ea glucose; tshireletso ya lisele tsa pancreatic β (apoptosis mahala) le tse latelang, tlhahiso ea insulin e sebetsang hantle e hokahaneng haholo.
Mokhoa o mocha oa kalafo bakeng sa lefu la tsoekere le tse amanang Syndromes ea metabolic, humanin e fana ka maikutlo a litsela tse tšepisang bakeng sa meriana.
COA
HPLC
MOF
