Pinealon

Lipatlisiso tse amanang le Pinealon

1.Mekhoa ea Ts'ebetso le Matla a Phekolo:

Tsamaiso e sebetsang ea sirtuin-1 polelo ea lefutso, ho potlakisa tlhahiso ea matla a mitochondrial, 'me ka mor'a moo ho fokotsoe khatello ea oxidative ke tse ling tsa litlamorao tse tlalehiloeng hantle.

Ho sireletsa li-neuron tsa hippocampal ho tse khethehileng immunoglobulin-ab oligomer tshenyo ke mosebetsi o mong oa bohlokoa, qalo ea litsela tsa apoptotic ho thibelwa haholo.

Katleho e kholo ea bokhoni ba ho ithuta le mesebetsi ea mohopolo ka kakaretso e hlokometsoe lithutong.

Liteko tsa mohlala oa liphoofolo li fana ka maikutlo a hore ho ka 'na ha e-ba le phokotseho ea kelello le thibelo ea lefu la neurodegenerative.

Boemong ba cellular tokiso ea neuronal, sebopeho sa synaptic (palo le boleng) le ka tekanyo e kgolo amyloid beta deposition/tau pathology kaofela li ntlafatsoa ke phaenelone.

Ho thibela le ho phekola cerebral ischemia, kotsi e bohloko ea boko le lefu la mokhathala o sa foleng kaofela li ka fihlella peptide ena e nang le likarolo tse ngata.

2.Taolo ea Liphatsa tsa lefutso le Mosebetsi oa Phetoho ea Gene

Sebopeho se senyenyane sa peptide ea pinealon e fana ka monyetla o ikhethang oa ho kenella lera la nyutlelie.

Tšebelisano e tobileng ea chromatin e ka khoneha.

Lipatlisiso sebakeng sena li bonts'a liphetoho tse tobileng tsa histone e le karolo ea mochine oa eona – ho fetola sebopeho sa chromatin.

Ho pholoha ha neuronal e sireletsang, phapang le liphatsa tsa lefutso tsa tlhokomelo ea ts'ebetso li sebelisoa ka mokhoa o ngotsoeng ke pinealon; khatello e kotsi ea lefutso e latela e le phello ea bobeli.

Ho ntlafatsa polelo ea liphatsa tsa lefutso ho tloha boemong ba 'motso’ ea bophelo bo botle ke e 'ngoe ea likarolo tse khahlisang haholo tsa ketso ea eona.

3.Ho ntlafatsa Lintho tsa Neurotrophic

Neurotrophic factor e tsoang bokong (BDNF) ka ho khetheha, le tsohle tse latelang tsa neuronal le synaptic plasticity, ke karolo e kholo ea se etsang hore phaenalon e be moemeli oa bohlokoa oa ho sireletsa methapo ea kutlo e le kannete.

4.Antioxidant le Neuroprotective Effects

Ho bokellana ho feteletseng ha mefuta ea oksijene e sebetsang ke sesosa se ka sehloohong sa mafu a neurodegenerative.

Pinealon e fokotsa li-radicals tsena tsa mahala; ho laola maemo a fapaneng a liphatsa tsa lefutso ka har'a sistimi ea endogenous antioxidant, Matla a bohlokoa a ts'ireletso ea antioxidant a matlafatsoa ho li-neurone.

Ho thibela polelo e hlakileng haholoanyane ea litsela tsa lipontšo tsa pro-apoptotic, lefu le hlophisitsoeng la neuronal lea thibeloa.

Leqeba la "cerebral ischemia-reperfusion" le mefuta e mengata ea neurotoxin li bontšitse bopaki bo hlakileng ba litlamorao tsa ts'ireletso ea Pinealon. – Phekolo ea pele e lebisa ho fokotseng boholo ba infarct le thibelo e kholo ea tahlehelo e amanang le neuronal.

Kotsi e matla ea boko le lits'ebetso tsohle tse latelang tse sa foleng tsa neurodegenerative bonyane li fokotsehile ka mokhoa ona oa tšireletso..

5.Ntlafatso ea Ts'ebetso ea Kelello le Ho Kopanya Mehopolo

Litlamorao tse pharalletseng tsa ntlafatso ea kelello li bonoe le Pinealon litekong tse ngata.

Liteko tse tloaelehileng (Motsoako oa metsi oa Morris ho ba mohlala o ka sehloohong, ho qoba ho etsa letho ho latela haufi) bontša lihlopha tse tšoaroang li ithuta kapele, ho bonts'a mohopolo o nepahetseng haholoanyane oa sebaka le ho ntlafatsa mohopolo oa nako e telele haholo.

Ho ntlafatsa ts'ebetso ea neural network, mofuta o mong oa ho tsepamisa maikutlo le ts'ebetso ea tlhahisoleseling ke seo Pinealon e bonahalang e se ama – liphello tse bonolo tse tsosang takatso ha se sepheo sa ho qetela.

Motlatsi oa 'nete oa kutloisiso, bonyane ka karolo e itseng, ke seo Pinealon e se emelang.