Tatelano ea amino acid ea Semax ke H-Met-Glu-His-Phe-Pro-Gly-Pro-OH. E fetotsoe ka hloko ho latela li-amino acid tsa bone ho isa ho tsa bosupa tsa sekhechana se nkiloeng ho hormone ea adrenocorticotropic (ACTH), phetoho ena e tlosa litla-morao tsa tlhaho tsa ACTH.
Ho boloka le maemong a mang ho matlafatsa thepa ea neuroactive le botsitso, Semax e bonts'a liphetho tse holimo haholo tse amanang le neuroprotection le mefuta e fapaneng ea ntlafatso ea kelello..
Ho ntlafatsa mekhoa ea ho ithuta le ho hopola, ho tsepamisa maikutlo, le lebelo la ts'ebetso ea tlhahisoleseling ke melemo e ikhethang eo ntho e fanang ka eona.
Tšusumetso e tobileng holim'a polasetiki ea synaptic (hippocampal le cerebral cortex ke mehlala e meholo) ke sona se khethollang Semax; ts'ebetso ea kelello e matlafatsoa ke taolo ea 'mele oa eona, ntle le bokhoba kapa mokhathala.
Ho hanyetsa ho tšoenyeha le liphello tsa adaptogenic le tsona li ngotsoe hantle, le hoja immunomodulation e ntse e ithutoa.
Ka kakaretso, litlamorao tsohle tse tsebahalang tsa neurotherapeutic tsa Semax li na le ts'episo e kholo; Lefu la Alzheimer, Lefu la Parkinson, glaucoma, khatello ea maikutlo, le maemo a mang a mangata a methapo ea kutlo kapa ea kelello, e tla rua molemo ho ntlafatso ea kelello e sebetsang e le kannete.
Tatelano
Ac-Met-Glu-His-Phe-Pro-Gly-Pro
Nomoro ea CAS
80714-61-0
Foromo ea limolek'hule
Setšoantšo sa C39H54N10O10S
Boima ba Molek'hule
854.99
Patlisiso ea Semax
1.Likopo tsa Kliniki le Liphuputso tsa Lipatlisiso
Ho ile ha fanoa ka tumello ea pele lilemong tsa bo-1990 bakeng sa phekolo encephalopathy le stroke (circulatory e amanang le ho ba mohlala o ka sehloohong), hammoho le mathata a mangata a methapo ea kutlo a lefu la tsoekere le sa itšetleheng ka insulin.
Patlisiso e tsoelang pele esale e bonts'a Semax ho loants'a letoto le fapaneng la lintho tse senyang tsa boko – ischemia, hypoxia, chefo, le khatello ea oxidative ho bolela tse 'maloa.
Ts'ebetso e matla ea antioxidant, e ntlafatsa metabolism ea matla a intracellular ka har'a boko, le ho phela ho matlafetseng ha lisele tsa boko kaofela ke liphello tse tlalehiloeng.
2.Liphello tsa Neuroprotective
Ha boko bo utloa bohloko ka lebaka la hypoxia, dintho tse chefo, khatello ea oxidative, kapa tsietsi e tobileng, lisele tsa boko li tsoela pele ho shoa kapa ho lahleheloa ke mosebetsi; kotsi e ke keng ea etsolloa e latela ka lebaka leo.
Semax e bonts'itsoe hore e thibela kapa bonyane e sitisa ts'ebetso ena ka litlamorao tse fapaneng tsa sepheo.
Bopaki ba liteko bo bontša ho phahama ha lintlha tse itseng tsa neurotrophic e le mochine o le mong; ts'ebetsong ea TRKB receptor latela, ka potlako ho qala phapang ea neuronal le litsela tse latelang tsa tokiso – ho eketsa monyetla oa ho phela ha neuronal.
Ho hatella chefo e matla haholoanyane ea li-amino acid tse hlasimollang ke ketso e 'ngoe ea bohlokoa, hammoho le ho thibela mohato oa ho qala oa cellular programmed apoptosis ka boeona.
Liteko tsa kliniki li bonts'a phokotso e sebetsang ea boholo ba infarct le phokotso ea edema ea boko ho bakuli ba ischemic stroke; motheo o tiileng bakeng sa likarolo tsohle tsa ho hlaphoheloa (tsa mmele le tsa kelello) e fanoa ke Semax.
3.Ntlafatso ea Kelello
Semax e laola botsitso ba tsamaiso ea li-neurotransmitters tse 'maloa – dopamine, serotonin, acetylcholine ho bolela tse mmalwa – ho theha e sebetsang hantle, tikoloho e tsitsitseng ka har'a tsamaiso ea methapo.
Synaptic plasticity libakeng tse mahlonoko (hippocampus ke mehlala ea mantlha, prefrontal le eona e bohlokoa) e susumetsoa ke molao ona.
Physiologically e laolang tšebetso ea boko e lebisa ho matla a kelello a ntlafetseng; ho ithuta le mohopolo (popeho, ho kopanya le ho bokelloa) kaofela li ntlafalitsoe, nako ea ho ela hloko e ile ea eketseha, tlhahisoleseling lebelo le ntlafalitsoe le ho hlaka kelellong ho tsosolosoa.
Lintho tse susumetsang tsa setso li baka tsitsipano le matšoenyeho a amanang le Semax ka botlalo.
4.Anti-matšoenyeho le Liphello tsa Adaptogenic
Boemo ba hypothalamic-pituitary-adrenal (HPA) axis e laola karabelo ea 'mele ea khatello ea maikutlo.
Ho tsitsisa sistimi ena ke seo Semax e ipabolang ho sona – e sa tloaelehang cortisol maemo le tšenyo eohle ea pathological eo ba e bakang ho tsoa khatellong e sa foleng ea fokotseha.
5.Neuro-Repair le Neurotrophic Effects
E kenya tshebetsong neurotrophic factor e tsoang bokong (BDNF)/TrkB le litsela tse ling tsa kholo ea kholo, Semax e fana ka mofuta oa 'tsosoloso’ ho li-neurone, ka bobedi ka sebopeho le tshebetso.
Ho hlophisa bocha boemo ba marang-rang le axonal ho ka finyelloa.
Li-neurone tse ntseng li phela li ka khona ebile li etsa joalo, ka karolo bonyane, kgutlela boemong bo batlang bo tlwaelehile ba tshebetso.
Selank le Semax hammoho ke motsoako o matla.
Motsoako ona o emela leano le ts'episang la neuroprotective.
COA
HPLC
MOF
