Vesugen ke tripeptide ea maiketsetso e nang le li-amino acid tse tharo (lysine-glutamic acid-aspartic acid, KED). Moqapi oa eona o tsoa ho peptide complex e arohaneng le lisele tsa methapo ea liphoofolo tse nyenyane, e tšehetsang ho lokisoa le ho sebetsa ha tsamaiso ea methapo ea mali, ka sepheo sa mantlha sa bophelo bo botle ba marang-rang a microvascular. Patlisiso le nts'etsopele ea mofuta ona oa peptide bioregulator li thehiloe haholo mosebetsing o entsoeng St. Petersburg Institute of Bioregulation le Gerontology, e reretsoeng ho matlafatsa methapo ea mali homeostasis ka ho etsisa likhechana tsa tlhaho tsa peptide.
Tatelano
Lys–Glu–Asp
Nomoro ea CAS
/
Foromo ea limolek'hule
C₁₆H₂₇N₅O₈
Boima ba Molek'hule
390.38
Patlisiso ea Vesugen
1.Nts'etsopele le Mohloli oa Vesugen
Nts'etsopele ea Vesugen e khothalelitsoe ke lithuto tsa setsi sa peptide se bitsoang "Ventfort®", e fumanoang methapong ea mali ea liphoofolo tse nyane. Bafuputsi ba fumane Vesugen tripeptide ka har'a setsi sena sa tlhaho mme ba e nka e le karolo ea bohlokoa e ikarabellang bakeng sa ts'ebetso ea taolo ea methapo.. Ka mor'a moo, Vesugen e ile ea etsoa ka lik'hemik'hale ka bohloeki bo phahameng. E le bioregulator e khuts'oane ea peptide, ho thoe ke ho lokisa li-microvessels, ntlafatsa phallo ea mali, le ho tšehetsa elasticity ea vascular, ka hona e khona ho thibela matšoao a pele a botsofali ba methapo ea mali.
2.Mokhoa oa ts'ebetso oa Vesugen o kenyelletsa taolo ea maemo a mangata a cellular le limolek'hule
(1).Khothatso ea Katoloso ea Lisele le Phapano
Mokhoa oa mantlha o reriloeng oa Vesugen ke ho feto-fetoha ha vascular endothelial cell proliferation. Lisele tsa Endothelial li etsa lera le le leng le le leng la methapo ea mali, 'me ho ata ha tsona le ho falla ke tsa bohlokoa bakeng sa ho lokisa methapo ea mali (angiogenesis) le ho boloka botšepehi ba methapo ea mali. The protheine ea Ki-67 ke lesupa le tiisitsoeng la ho ata ha lisele, ka boemo ba eona ba polelo e amanang haufi le ts'ebetso ea mitotic.
Lipapiso tse tebileng tsa limolek'hule tsa limolek'hule li fana ka maikutlo a hore Vesugen e ka tlama sebakeng sa motšehetsi oa lefutso. (MKI67) ho kenyelletsa protheine ea Ki-67, ka ho etsa joalo e laola ponahalo ea eona le ho khothalletsa ho ata ha lisele. Sephetho sena se fana ka tlhaloso e khethehileng ea biological molek'hule bakeng sa Vesugen's ho thoeng “tokiso ea methapo” mosebetsi-e leng, ho lokisa likepe tse senyehileng ka ho khothaletsa nchafatso ea vascular endothelial cell¹.
(2).Taolo ea Gene Expression le Chromatin State
Vesugen e ka tlama ka ho khetheha ho DNA, ho fetola chromatin conformation le gene transcriptional activity, e amang motsoako oa liprotheine tse fapaneng tse amanang le ts'ebetso ea methapo.
Ka mohlala, e ka fokotsa polelo ea mabaka a ho ruruha (joalo ka CXCL12) le tieho bofokoli ba cellular².
(3).Khothatso ea Angiogenesis le Nchafatso
Liteko tsa in vitro li bonts'a hore Vesugen e na le litlamorao tse sireletsang liseleng tsa methapo, ho ntlafatsa microcirculation le ho matlafatsa mesifa ea mesifa. Liphello tsena tse kopantsoeng li tlatsetsa bokhoni ba eona ba ho lokisa likepe tse nyenyane, ho ntlafatsa phallo ea mali, le ho khutlisa botsofali ba pele ba methapo ea mali.
E ka kena khubung ka lipalangoang tsa peptide (mohlala, Pept1 le Lat1), sebelisana le DNA kapa histones, kenya tšebetsong li-cascade tsa mats'oao a cellular, 'me ka hona e khothalletse ho qaptjoa ha vascular elastin le ho ntlafatsa microcirculation³.
(4).Ntlafatso ea Khatelo-pele ea Khatello le Matla a Antioxidant
Vesugen e ka ntlafatsa mamello ea 'mele ho maemo a sithabetsang joalo ka hypoxia le ho fokotsa tšenyo ea oxidative liseleng tsa neural le vascular., e ka bang teng ka ho feto-fetoha ha litsela tsa matšoao a intracellular (mohlala, PI3K/ACT).
3.Liphello tsa Neuroprotective le Likopo tse Pharalletseng
Lipatlisiso li bontša hore Vesugen e eketsa palo ea mokokotlo oa dendritic- e amanang le polasetiki ea synaptic-ka li-neuron tsa hippocampal, ka tsela e sa tobang ho tšehetsa bophelo bo botle ba cerebral microvascular le phallo ea mali.
Lithuto tsa liphoofolo li bonts'itse hore Vesugen e ka sireletsa methapo ea boko ho tsoa tšenyong ea hypoxic⁴.
4.Likopo tsa Clinical le Tšebeliso
Ts'ebeliso ea Vesugen e shebane haholo le tlhokomelo ea bophelo bo botle ba pelo le taolo ea mafu a adjunctive.. E kgothaletswa bakeng sa maemo a sa tšoaneng a amanang le methapo ea mali, ho akarelletsa le arterial khatello ea mali, methapo ea mali lefu la atherosclerosis, methapo ea varicose, thrombophlebitis, le mathata a sebaka sa microcirculation (mohlala, liso tsa trophic)⁴.
Ho feta moo, e sebelisetsoa ho tšehetsa maemo a amanang le ho potoloha ha mali bokong (joalo ka cerebral atherosclerosis le sequelae ea likotsi tsa cerebrovascular) le bakeng sa ho thibela ho fokotseha ho amanang le lilemo mosebetsing oa vascular⁵.
Lisebelisoa tse ling, Vesugen e boetse e hlahlojoa bakeng sa ho fokotsa tšusumetso ea khatello ea kelello le maikutlo le maemo a feteletseng a tikoloho ho vascular system¹.
5.Kakaretso le Boemo ba Hona Joale
Vesugen, joalo ka moemeli ea thehiloeng ho peptide e shebileng bophelo bo botle ba methapo, e sebetsa ka taolo ea boemo ba liphatsa tsa lefutso le ho ntlafatsa ts'ebetso ea lisele. Hajoale e sebelisoa haholo-holo ka har'a liphekolo tsa bioregulator naheng ea Russia le libakeng tse ling tsa Europe.
COA
HPLC
MOF
