Acetyl Hexapeptide-49 shine peptide ɗan gajeren sarkar roba. Ana magana a matsayin a “hexapeptide”, Kashin bayansa na kwayoyin halitta ya ƙunshi amino acid guda shida waɗanda aka haɗa su ta hanyar haɗin peptide; rukunin amino N-terminal acetylated ne, da farko don ƙãra kwanciyar hankali da haɓakar fata. Wannan peptide ya sami tartsatsi aikace-aikace a cikin kayan shafawa da kuma niyya tsarin kula da fata, fata m kasancewa daya daga cikin manyan yanayin da aka tsara don magance.
Jeri
Ac-Phe-Phe-Trp-Phe-His-Val-NH2
Lambar CAS
1969409-70-8
Tsarin kwayoyin halitta
Saukewa: C51H58N10O7
Nauyin Kwayoyin Halitta
923.07 g/mol
1.Menene acetyl Hexapeptide-49
Sakamakon anti-sensitizing da kwantar da hankali na Acetyl Hexapeptide-49 ya fito ne daga takamaiman hana shi na mai karɓar siginar maɓalli. – Mai karɓar Protease-Kunna 2 (PAR-2). PAR-2 kanta a G mai haɗakar da furotin, yadu da aka bayyana akan ƙwayoyin fata daban-daban da ƙwayoyin jijiya; yana taka muhimmiyar rawa wajen daidaita kumburin fata, ƙaiƙayi, da kumburi neurogenic.
A ƙarƙashin yanayin al'ada kunnawa yana faruwa ta takamaiman ƙwayoyin cuta na serine (tryptase daga mast cells shine babban misali, mahalli allergen proteases kuma bauta wa wannan manufa). Ragewar yankin N-terminal extracellular na PAR-2 yana fallasa wannan jerin labari azaman 'ligand mai ɗaure'; ɗaure baya ga mai karɓan da aka kunna a yanzu shine abin da ke fara cikakkiyar sigina na ƙasa.
Acetyl Hexapeptide-49 yana aiki azaman babban mai adawa da wannan tsari, yadda ya kamata ya rushe hanyar sigina ta farko da ke kaiwa ga hankali. Ragewa a cikin duka IL-6 da Interleukin 8 (IL-8) martani mai kumburi, kuma zuwa babban mataki Farashin TRPV-1 (da duk abin da ya biyo baya tare da CGRP) kunnawa, duk kai tsaye tasirin wannan hanawa ne.
2.Binciken Acetyl Hexapeptide-49
1)Rage Cutar Neurogenic
Kunna PAR-2 yana ƙarfafa ƙarshen jijiyoyi don sakin neuropeptides da yawa, peptide mai alaka da calcitonin (Farashin CGRP) kasancewarsa na farko. CGRP yana aiki azaman vasodilator mai ƙarfi; jajayen fata, edema, kuma yanayin konewar yanayi duk sakamakon sakinsa ne kai tsaye.
Nazarin in vitro sun nuna acetylhexapeptide-49 don hana PAR-2-haɗaɗɗen sakin CGRP, yadda ya kamata sarrafa nau'i-nau'i daban-daban na amsawar kumburi na neurogenic.
Gwajin ɗan adam a cikin vivo daga masu samar da kayayyaki yana nuna ƙirar da ke ɗauke da rage shi (sau da yawa gaba daya ragewa) ƙonawa da ƙonawa da ke tattare da ƙayyadaddun abubuwan da ke haifar da haɓakar sinadarai – Lactic acid da capsaicin sune manyan misalai. Tabbatar da kai tsaye na tasirin tsari akan jijiyoyi masu hankali ana bayar da su ta waɗannan gwaje-gwaje.
2)Hana Haɓaka Samar da Cytokine mai kumburi
A cikin keratinocytes kansu, Kunna PAR-2 yana haifar da bayyanar da kewayon cytokines masu kumburi da chemokines. (IL-6 zama misali mai kyau, IL-8 kuma yana da matukar dacewa). Daukar sel na rigakafi wani bangare ne na amsa mai kumburi mai zuwa; rage waɗannan masu shiga tsakani bayyanannen manufar hana kumburi ne.
Gwaje-gwaje na goyan bayan tasirin Acetyl Hexapeptide-49 kai tsaye akan waɗannan abubuwan.
3)Yana dawo da aikin shingen fata
Kumburi na yau da kullun shine babban dalilin rashin lahani ga shingen halitta na fata. Hana hanyoyin kumburin da aka ambata a baya (PAR-2 shine farkon fararwa) yana ba da damar ƙarancin lalacewa ga wannan shinge, gyaran kai zai iya faruwa, kuma zuwa wani lokaci za a gamu da fushin waje tare da mafi ‘na al’ada’ matakin juriya.
3.Kammalawa
Acetyl Hexapeptide-49 shine peptide neuro-soothing. Dukkanin layukan shaida guda uku suna nuni da shi a matsayin ɗan takarar da ya dace sosai don yin magani ko aƙalla gyara fata mai laushi.
COA
HPLC
MS
