Acetyl hexapeptide 1 (aha ahia Melitane) bụ ihe sịntetik bioactive peptide.
Emeela nyocha sara mbara na ihe a, na ngwa ya n'ime ogige ịchọ mma na-edepụta nke ọma.
Ya multifunctional mgbochi wrinkle, rụkwaa, na ihe ndị na-echebe akpụkpọ ahụ na-amata nke ọma.
Usoro
Ac-{Nwere ike}-Ala-His-{d-Phe}-Arg-Trp-NH2
Nọmba CAS
448944-47-6
Usoro ihe omimi
C43H59N13O7
Ibu molekụla
870.01 g/mol
Nnyocha nke Acetyl Hexapeptide 1
Acetyl hexapeptide 1 na-egosiputa ọtụtụ ọrụ ndu akụkụ dị iche iche; A na-enweta mmetụta ndị a na-anabatakarị site na ụzọ abụọ dị iche iche nke molekụla.
Ịlụso ọgụ megide wrinkles na iwu pigmenti bụ isi ihe atụ nke ike ndị a.
Ọrụ kacha mara amara – mgbochi wrinkle bụ nke mbụ – lekwasịrị anya ahịrị okwu (ike wrinkles kpọmkwem).
Yiri acetyl Hexapeptide-8 (Argireline), usoro ihe omume a bụ ihe na-akọwa ojiji ya.
Isi usoro mgbochi wrinkle gụnyere itinye aka na nnyefe mgbaàmà na nkwụsị nke neuromuscular.
Ọmụmụ ihe na-egosi mmekọrịta presynaptic na postsynaptị n'otu oge.
Presynaptically, mpi njikota Ọrụ - protein 18 na-egbochi zuru ezu Soluble N-ethylmaleimide-sensitive factor Mgbakwunye protein nnata (SNARE) mgbakọ mgbagwoju anya, ntọhapụ acetylcholine belatara bụ nsonaazụ ozugbo.
Ime ka mgbaama mgbagha nke anụ ahụ n'onwe ya na-enweta na-eduga n'ịtụ ahụ ike.
Postsynaptically, Acetylcholine (ACH) egbochiri ọrụ nnabata, a na-ebelata ntuba calcium, Mkpụkọ akwara belatara wee si otú a wrinkles dị ike belatara.
Mgbochi arụmọrụ ruru 37% (SNARE metụtara) na 29% Ntọhapụ acetylcholine na-egosi uru ike doro anya karịa Argireline.
Nke abụọ, ma ọ dịkwa mkpa, Ọrụ dị mkpa nke Acetyl Hexapeptide 1 bụ ọrụ agonist ya n'ebe α-MSH nọ.
α-MSH eke bụ homonụ na-akpata; na-ekekọta Melanocortin 1 onye nnata (MC1R) Ndị na-anabata melanocyte na-amalite nrịbama metụtara pigmenti.
Acetyl hexapeptide 1 na-eṅomi ọrụ a.
Nlekọta agba ntutu na igbu oge nke isi awọ, site na mkpali nke melanocytes, bụ otu n'ime ngwa ahịa bara uru nke usoro nyocha a.
A 2023 Ọmụmụ nyocha nyochara ịdị irè nke serum nwere retinol supramolecular na acetyl hexapeptide. 1 na imeziwanye akpụkpọ ihu dị nro nke foto.
Ụmụ nwanyị China dị afọ iri atọ na abụọ sonyere na ọmụmụ ihe ahụ; oge ọgwụgwọ nke izu 8 bụ isi ihe nyocha ahụ.
Nkwalite n'akụkụ dị iche iche nke isiokwu’ Ahụrụ ọnọdụ akpụkpọ ahụ.
Ugbu a, Acetyl hexapeptide 1 etinyere n'ọtụtụ ebe na ngwaahịa mgbochi ịka nká adịchaghị – serum bụ ụdị a na-ahụkarị, nwere ude na ngwaahịa anya pụrụ iche na-esote uwe.
Ngwakọta neuromodulatory ọdịnala (botulinum toxin bụ isi ihe atụ) etinyela ụkpụrụ maka ihe mgbochi ịka nká dị irè nwere ike ịdị ka; ngwa na-adịghị emerụ ahụ, nchekwa dị elu, na nnabata dị mma na-eme acetyl hexapeptide 1 dị mma maka ogologo oge iji kwa ụbọchị na nlekọta anụ ahụ.
COA
HPLC
MS
