Myristoyl Pentapeptide-8 bụ peptide ịchọ mma bioactive arụpụtara site na mgbanwe kemịkalụ nke eke. usoro nrịba ama.
A na-ekwu na uto ntutu ya pụrụ iche na ọrụ ịchọ mma dị iche iche sitere na mpempe pentapeptide echekwara echekwabara., Lys-Thr-Thr-Lys-Ser, ewepụtara site na α1 yinye nke ụdị m procollagen.
Ihe na-akọwa ya bụ ịkpali dermal fibroblasts , si otú a na-amalite cascade na-esote nke na-akwalite njikọ nke abụọ ahụ collagen na fibronectin.
Agbanyeghị, nbibi nke enzymatic ngwa ngwa na-enye ihe mgbochi dị mkpa na ngwa ọgwụgwọ ya bara uru.
Iji merie nke a, ndị nchọpụta gbanwela peptide site na njikọ ya na a abụba acid yinye. Mgbanwe a na-echekwa njirimara ụgwọ mbụ ebe ọ na-emeziwanye ndakọrịta na intercellular lipids nke stratum corneum.
N'ihi ya, Mgbanwe ahụ na-agbatịkwu peptide ọkara ndụ na budata mma ya transdermal ntinye arụmọrụ.
Na nchịkọta, peptide a na-arụ ọrụ ịchọ mma dị ike, na-echekwa ọnọdụ ya na usoro nlekọta anụ ahụ adịchaghị.
Usoro
Lys-Thr-Thr-Lys-Ser (KTTKS)
Nọmba CAS
2305730-23-6
Usoro ihe omimi
C37H71N7O10
Ibu molekụla
774.01
Nnyocha metụtara Myristoyl Pentapeptide-8
1.Njikọ Dermal-Epidermal na nkwalite Ọdịdị akpụkpọ ahụ
Ihe akaebe na-egosi na Myristoyl Pentapeptide-8 na-eṅomi akara ngosi ndu nke lamini-5, si otú ahụ na-ewusi ike na ịrụzi nhazi na ọrụ nke dermal-epidermal junction (MMIRI).
Ọ na-akpali dermal fibroblasts ka synthesize na ikpokọta igodo okpuru ulo akpụkpọ ahụ components, gụnyere collagen I, III, na elastin.
Nsonaazụ ikpeazụ bụ mgbidi nke ime ụlọ nke anụ ahụ, nke na-ebelata omimi na ọnụ ọgụgụ wrinkles (na ọnwụ nke ngbanwe bụ isi ihe na-enye aka), na-eduga na akpụkpọ ahụ siri ike ma dị mma karịa.
Ọ na-emetụtakwa nke ọma keratinocyte iche na keratin polymerization.
2.Nkwalite ozugbo nke Dermal Collagen Regeneration
Dị ka e kwuru, peptide na-ejikọ ma na-arụ ọrụ protein metụtara nnabata LDL (LRP/LDL protein metụtara nnabata) n'elu fibroblast, na-ebute mmetụta ndị ahụ e kwuru n'elu.
3.Iwu nke okirikiri uto ntutu follicle
Myristoyl Pentapeptide-8 na-arụ ọrụ ụzọ akara β-catenin/LEF1 n'ime. papilla dermal mkpụrụ ndụ.
Omume a na-egbochi BMP4-kpalitere mgbama mgbagha, si otú ahụ na-agbatị ogologo oge anagen (uto) oge nke ntutu follicle.
Ihe akaebe nnwale sitere na ụdị òké nke androgenic alopecia na-akwado usoro a; ngwa na-aga n'ihu maka 21 ụbọchị dugara n'ịba ụba nku anya, nku anya, na njupụta ntutu isi.
4.Ịkwalite ọrụ mgbochi akpụkpọ ahụ na Ọrụ Antioxidant
Ọdịdị pụrụ iche nke Myristoyl Pentapeptide-8 na-enye nkwụsi ike ka mma, na myristoyl moiety n'onwe ya na-ebute ihe mgbochi siri ike.
Ọ na-ebelata ọnụ ụzọ mmalite maka ihe mkpali, si otú ahụ na-emeziwanye ike nke akpụkpọ ahụ na nrụgide gburugburu ebe obibi.
Ọ na-akwado sel epidermal nkịtị na usoro metabolic ya.
Ọzọkwa, ọ na-akwalite njikọ nke isi lipids (gụnyere ceramides) n'ime stratum corneum, N'ikpeazụ na-ewusi ihe mgbochi anụ ahụ ike na ịmepụta ebe akpụkpọ anụ kachasị mma.
Ihe ga-esi na ya pụta bụ mma nkwụsi ike akpụkpọ.
COA
HPLC
MS
