AHK bụ tripeptide nke nwere amino acid atọ mejupụtara: alanine (Ala), histidine (Ya) na lysine (Lys).
Obere peptide a nwere ezigbo mma transdermal absorption.
A kwenyere na n'ihi amino acids nwere otu ndị na-enye onyinye elektrọn, dị ka histidine na lysine pụtara na nhazi ya, ọ nwere ike ịbọ ọbọ free radicals ma chebe lipids si peroxidation na-agbasi mbọ ike antioxidant ọrụ.
Ma njikọ kemịkal na nnọpụ iche site na proteolysate nke eke protein (eg., azụ azụ mmiri, protein mmiri ara ehi) enwere ike imepụta AHK ugbu a.
N'adịghị ka ọtụtụ n'ime macromolecular antioxidants, AHK nwere ibu molekụla dị ala karịa ma ka mma biocompatibility, nke nwere ike dabara adaba dị ka ihe ịchọ mma na-arụ ọrụ.
Usoro
Ala-His-Lys
Nọmba CAS
126828-32-8
Usoro ihe omimi
C15H26N6O4
Ibu molekụla
354.40
Nnyocha metụtara AHK
Ha nwere mmasị karịsịa na ọrụ antioxidant ma tụpụta ya: Isi mmetụta nke AHK bụ n'ihi ọrụ antioxidative ya, nke ewepụtara site na usoro omume ndị a:
1.Ikpochapụ ROS
ROS bụ otu n'ime ihe kacha njọ maka ịkpata oxidation cell na ịka nká na akpụkpọ ahụ.
The kpọmkwem nyefe nke eletrọn ma ọ bụ hydrogen atọm ka free radicals onwe ha maka inactivation ROS site na ọtụtụ peptides antioxidant, na-eme ka mkpochapụ ROS.
Nke histidine na lysine ihe fọdụrụ nke AHK nwere ike inye hydrogen atom ma ọ bụ electrons iji mebie ROS radicals. (DPPH, ABTS) ozugbo iji kwụsị oxidative mmeghachi omume yinye.
A kọwapụtara na peptides nwere histidine nwere ike mebie radicals site na SET (Otu Nyefe Eletrọnịkị) ma ọ bụ Okpu (Nbufe hydrogen Atọm) usoro.
2.Ịgbalite sistemu Antioxidant Endogenous
Ụfọdụ peptides antioxidant na-abawanye ikike mgbochi oxidative cell site na-akpali akpali anti-oxidases intracellular isi. (eg., superoxide dismutase SOD, glutathione peroxidase GSH-Px)².
N'ụdị cell ụfọdụ, Ụdị peptides nke AHK nwere ike ịkwalite nkwupụta nke enzymes antioxidant endogenous dị ka SOD na GSH-Px., nke nwere ike n'aka nke na-eme ka nchekwa sel dị ike megide nrụgide oxidative.
3.Metal ion Chelation
Nke imidazole mgbanaka nke histidine na amino group lysine nwere ike gbakọta ya ion mgbanwe metal (dị ka Fe²⁺, Ku²⁺), nke ga-attenuate metal-catalyzed Fenton reactivity, si otú a na-eduga na mgbochi na hydroxyl radical nhazi.
Ya ọla kọpa ion mgbagwoju (AHK-Cụ, nke a na-akpọkarị GHK-Cu ma ọ bụ ọla kọpa tripeptide-1) –kama AHK naanị– nwere ihe guzosie ike na ghọtara ojiji na ntecha.
Enwetara uru na antioxidant, ntinyeghachi nke collagen na nrụzi ngwa ngwa, E tinyela AHK n'ụdị ngwaahịa nlekọta anụ ahụ dị iche iche.
4.Maka ngwaahịa ọ bụla na-egbochi ịka nká na ngwaahịa ude
Na-agbatị akpụkpọ ahụ rụrụ arụ na ibelata wrinkles site na ịkwalite syntony collagen & ịlụ ọgụ megide nrụgide oxidative.
5.Maka post-ịwa ahụ ma ọ bụ ọnya-mmezi ihe ịchọ mma
Na-akwalite usoro nkwụghachi epidermial ka ọ na-ebelata oge mgbakasị ahụ metụtara.
Na ntutu isi na nlekọta ntutu ịchọ mma: Nnyocha e mere gosiri na ọ nwere ikike ịkwalite ya angiogenesis gburugburu ntutu isi iji nweta ntutu isi& na-eme ka ọ nwee ike iji shampoos na-egbochi ọnwụ ma ọ bụ serum nke uto.
Ọzọkwa, n'ụdị antioxidant, AHK nwere ike ịgbakwunye uru na ihe ndị dị ka vitamin C na E, na-akwalite mmetụta netwọkụ na-egbochi oxidant pụrụ iche nke nlekọta anụ ahụ nke nwere ike imeziwanye nchekwa * 1 na ịrụzi ọrụ na akpụkpọ ahụ..
COA
HPLC
MS
