Acetyl Hexapeptide-38 (aha ahia Adifyline®) bụ peptide sịntetik nke a na-ejikarị n'ime ọgwụ ịchọ mma na nrụzi akpụkpọ ahụ. Ezubere iche dermal fibroblasts, ọ na-akwalite njikọ nke collagen na abụba subcutaneous; mmelite nke nhazi akpụkpọ ahụ na ụdị dị iche iche nke nrụzi anụ ahụ bụ nsonaazụ kpọmkwem nke ọrụ a.
Usoro
Ac-Ser-Val-Val-Val-Arg-Thr-NH₂
Nọmba CAS
1400634-44-7
Usoro ihe omimi
C30H56N10O9
Ibu molekụla
700.83 g/mol
Kedu ihe bụ Acetyl Hexapeptide-38
Acetyl Hexapeptide-38 n'onwe ya bụ peptide gbanwere acetylated – amino acid isii n'ogologo. Nhazi molikula nke peptide na-eṅomi peptides bioactive eke, na agbakwunyere uru nke ụba nkwụsi ike na enwekwukwa akpụkpọ permeability.
Ndị ụlọ ọrụ ịchọ mma na biomaterial mepụtara na mbụ, nchegbu ịka nká akpụkpọ (wrinkles, laxity, ntụpọ anụ ahụ dị nro bụ ihe atụ bụ isi) bụ ihe e kere peptide a iji lebara ya anya. Nnyocha egosila nbanye nke ọma gafere ihe mgbochi akpụkpọ mbụ; na-eme n'ime dermis, Usoro nke usoro metabolic nke extracellular matrix bụ usoro bụ isi nke na-eduga n'ụdị nrụzigharị na nrụzi na-esote..
Ya mere, isi ọrụ nke acetyl Hexapeptide-38 bụ onye na-akwalite mmezi anụ ahụ sara mbara. Akpụkpọ anụ fibroblasts na adipocytes bụ ndị bụ isi lekwasịrị anya, na kpọmkwem usoro ndu ka a na-ahazi n'oge niile.
Ugbu a usoro a na-ekwukarị na-agụnye ịkpali okwu nke Peroxisome Proliferator Na-anabata Gamma Coactivator 1-alpha (PGC-1a). PGC-1a bụ isi nchịkwa nke mitochondrial biogenesis na ihe niile metụtara ume metabolism. Mbelata nke protein a na-eme ka ahụ sie ike (opekata mpe) ụbara njikọ lipid na mkpokọta adipocytes – mmụba nke anụ ahụ adipose bụ njedebe ikpeazụ. Mmụba akpụkpọ ahụ na mbelata atrophic wrinkles bụ ma ezigbo ụlọ ọgwụ na-egosi mmetụta a.
Ngwongwo a na-eme ka ụdị okike dịkwuo elu nke na-abawanye oke abụba (ihu ihu, ara wdg.) a ga-enweta; ‘peptide nkwalite ara’ bụ nkọwa nkịtị nke opekata mpe ụfọdụ n'ime ojiji ya.
Acetyl Hexapeptide-38 na-eme ka njupụta na nkwụsi ike nke collagen eriri na dermis, dị ka e kwuru na mbụ, site na mmetụta niile jikọtara ọnụ n'elu.
Dabere na usoro niile akọwara, Acetyl Hexapeptide-38 nwere ezigbo ọdịnihu dị mma na ọgwụ ịchọ mma. Ndozi ụzọ abụọ na ịgbatị anụ ahụ dị nro bụ ebe njedebe na-achọsi ike.
Acetyl Hexapeptide-38 bụ onye na-akwalite mmezi akpụkpọ ahụ na-ekwe nkwa.
COA
HPLC
MS
(2) DELGADO GONZÁLEZ, R.; Ụlọ ọrụ SOLEY ASTALS, A.; Ụlọikpe, A.; THOLLAS, B. EXOPOLYSACCARID maka ọgwụgwọ na/ma ọ bụ ilekọta akpụkpọ ahụ, MMEMBRANES na/ma ọ bụ mbọ. EP2827837B8.
(3) Wu, Y.; Ee, H.; Lyu, Y. Ọganihu nyocha nke peptides collagen eke na nlekọta anụ ahụ ya. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2022, 39 (6), 1254-1262. DOI: 10.7507/1001-5515.202207009 Site na NLM.





